UHRF1 maintains DNA methylation by recruiting DNA methyltransferases to chromatin. In mouse, these dynamics are potently antagonized by a natural UHRF1 inhibitory protein STELLA, while the comparable effects of its human ortholog are insufficiently characterized, especially in cancer cells. Herein, we demonstrate that human STELLA (hSTELLA) is inadequate, while mouse STELLA (mSTELLA) is fully proficient… Continue reading Defining ortholog-specific UHRF1 inhibition by STELLA for #cancer therapy
Category: Gastroenterology
Comparison between two divergent diets, #Mediterranean and #Western, on #gut #microbiota and cognitive function in young sprague dawley rats
Clinical studies strongly suggest the importance of diet quality on cognition in youth populations (15–24 years). The Mediterranean diet (MeDi) has been shown to improve cognition in contrast to the commonly consumed Western diet (WD). The gut microbiota may serve as a mechanism for diet-induced changes in cognition. Ten-week-old male Sprague Dawley rats were assigned a… Continue reading Comparison between two divergent diets, #Mediterranean and #Western, on #gut #microbiota and cognitive function in young sprague dawley rats
Gut #microbiota markers in early #childhood are linked to #farm living, pets in household and allergy
BackgroundChildren growing up on farms or with pets have a lower risk of developing allergy, which may be linked to their gut microbiota development during infancy MethodsChildren from the FARMFLORA birth cohort (N = 65), of whom 28 (43%) lived on a dairy farm and 40 (62%) had pets, provided fecal samples at intervals from… Continue reading Gut #microbiota markers in early #childhood are linked to #farm living, pets in household and allergy
#Coffee consumption is associated with intestinal #Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
Although diet is a substantial determinant of the human gut microbiome, the interplay between specific foods and microbial community structure remains poorly understood. Coffee is a habitually consumed beverage with established metabolic and health benefits. We previously found that coffee is, among >150 items, the food showing the highest correlation with microbiome components. Here we… Continue reading #Coffee consumption is associated with intestinal #Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts
Gut #microbiota regulates #stress responsivity via the circadian system
SummaryStress and circadian systems are interconnected through the hypothalamic-pituitary-adrenal (HPA) axis to maintain responses to external stimuli. Yet, the mechanisms of how such signals are orchestrated remain unknown. Here, we uncover the gut microbiota as a regulator of HPA-axis rhythmicity. Microbial depletion disturbs the brain transcriptome and metabolome in stress-responding pathways in the hippocampus and… Continue reading Gut #microbiota regulates #stress responsivity via the circadian system
Dynamics of the gut #microbiome in individuals at risk of #rheumatoid arthritis: a cross-sectional and longitudinal observational study
Objectives This work aimed to resolve the conflicting reports on Prevotellaceae abundance in the development of rheumatoid arthritis (RA) and to observe structural, functional and temporal changes in the gut microbiome in RA progressors versus non-progressors.Methods Individuals at risk of RA were defined by the presence of anticyclic citrullinated protein (anti-CCP) antibodies and new musculoskeletal… Continue reading Dynamics of the gut #microbiome in individuals at risk of #rheumatoid arthritis: a cross-sectional and longitudinal observational study
Identification of distinct #stool metabolites in women with #endometriosis for non-invasive diagnosis and potential for microbiota-based therapies
Context and significanceClinical management of endometriosis, a gynecological disease that is a leading cause of infertility in women, remains a challenge with no known cure. Scientists from Baylor College of Medicine combined the gut metabolomic and microbiota signatures in the stool samples from women with endometriosis to identify a gut-bacteria-derived therapeutic intervention candidate, 4-hydroxyindole. They… Continue reading Identification of distinct #stool metabolites in women with #endometriosis for non-invasive diagnosis and potential for microbiota-based therapies
#Antibiotics damage the #colonic mucus barrier in a #microbiota-independent manner
Antibiotic use is a risk factor for development of inflammatory bowel diseases (IBDs). IBDs are characterized by a damaged mucus layer, which does not separate the intestinal epithelium from the microbiota. Here, we hypothesized that antibiotics affect the integrity of the mucus barrier, which allows bacterial penetrance and predisposes to intestinal inflammation. We found that… Continue reading #Antibiotics damage the #colonic mucus barrier in a #microbiota-independent manner
Upper #Gastrointestinal Mucosal Damage and Subsequent Risk of #Parkinson Disease
Importance The gut-first hypothesis of Parkinson disease (PD) has gained traction, yet potential inciting events triggering Parkinson pathology from gut-related factors remain unclear. While Helicobacter pylori infection is linked to mucosal damage (MD) and PD, it is unknown how upper gastrointestinal MD from any source increases PD risk.Objective To evaluate any association between upper endoscopy findings of MD and… Continue reading Upper #Gastrointestinal Mucosal Damage and Subsequent Risk of #Parkinson Disease
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