Patients with persistent critical illness may account for up to half of all intensive care unit (ICU) bed-days. It is unknown if there is hospital variation in the development of persistent critical illness and if hospital performance affects the incidence of persistent critical illness.. In the analysis of 100 hospitals which encompassed 153,512 hospitalizations, 4.9%… Continue reading Hospital-level variation in the development of persistent critical illness
Category: Environment
Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility
coronavirus 2 (SARS-CoV-2) infection can spread rapidly within skilled nursing facilities. After identification of a case of Covid-19 in a skilled nursing facility, we assessed transmission and evaluated the adequacy of symptom-based screening to identify infections in residents.. ..Twenty-three days after the first positive test result in a resident at this skilled nursing facility, 57… Continue reading Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility
Association of Stay-at-Home Orders With COVID-19 Hospitalizations in 4 States
In analyses of the effectiveness of response measures to the outbreak of coronavirus disease 2019 (COVID-19), most studies have used the number of confirmed cases or deaths. However, case count is a conservative estimate of the actual number of infected individuals in the absence of community-wide serologic testing. Death count is a lagging metric and… Continue reading Association of Stay-at-Home Orders With COVID-19 Hospitalizations in 4 States
Adverse effects of electronic #cigarettes on the disease-naive oral #microbiome
Six percent of Americans, including 3 million high schoolers, use e-cigarettes, which contain potentially toxic substances, volatile organic compounds, and metals. We present the first human study on the effects of e-cigarette exposure in the oral cavity. By interrogating both immunoinflammatory responses and microbial functional dynamics, we discovered pathogen overrepresentation, higher virulence signatures, and a… Continue reading Adverse effects of electronic #cigarettes on the disease-naive oral #microbiome
FDA Approves Only Drug in U.S. to Treat Severe #Malaria
Today, the U.S. Food and Drug Administration approved artesunate for injection to treat severe malaria in adult and pediatric patients. Treatment of severe malaria with intravenous (IV) artesunate should always be followed by a complete treatment course of an appropriate oral antimalarial regimen. Prior to this approval, IV artesunate was only available to patients through… Continue reading FDA Approves Only Drug in U.S. to Treat Severe #Malaria
Cigarette #smoke exposure and inflammatory signaling increase the expression of the #SARS-CoV-2 receptor ACE2 in the respiratory tract
Abstract The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show that cigarette smoke causes a dose-dependent upregulation of Angiotensin Converting Enzyme 2 (ACE2), the SARS-CoV-2 receptor, in rodent and human lungs. Using single-cell sequencing data, we demonstrate that ACE2 is expressed in a subset of secretory cells in the respiratory tract. Chronic… Continue reading Cigarette #smoke exposure and inflammatory signaling increase the expression of the #SARS-CoV-2 receptor ACE2 in the respiratory tract
Risk factors for #SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study
There are few primary care studies of the COVID-19 pandemic. We aimed to identify demographic and clinical risk factors for testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre primary care network.. ..We identified 3802 SARS-CoV-2 test results, of which 587… Continue reading Risk factors for #SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study
Fine Particulate Matter Air #Pollution and Mortality among Pediatric, Adolescent, and Young Adult Cancer Patients
Air pollution is a carcinogen and causes pulmonary and cardiac complications. We examined the association of fine particulate matter pollution (PM2.5) and mortality from cancer and all causes among pediatric, adolescent, and young adult (AYA) patients with cancer in Utah, a state with considerable variation in PM2.5.. ..Increases in PM2.5 per 5 μg/m3 were associated… Continue reading Fine Particulate Matter Air #Pollution and Mortality among Pediatric, Adolescent, and Young Adult Cancer Patients
Spending time in the #garden is positively associated with health and #wellbeing: Results from a national survey in England
Research has found that natural environments within urban areas are associated with benefits for human health and wellbeing. However, most studies have primarily focused on publically accessible green space. Less is known about domestic gardens, which in the UK comprise a high proportion of land cover in urban areas and could form a resource for… Continue reading Spending time in the #garden is positively associated with health and #wellbeing: Results from a national survey in England
2 Medical News 