Background: Rheumatoid arthritis (RA)-related physical limitations often hinder sustained physical activity and weight management, thereby amplifying cardiovascular risk through adverse metabolic profiles and chronic inflammation. We aimed to assess the effectiveness of semaglutide on the risk of incident major adverse cardiovascular and cerebrovascular events (MACCE) in obese adults with type 2 diabetes mellitus (T2DM) and… Continue reading Semaglutide for Primary Prevention of Major Adverse Cardiac and Cerebrovascular Events in Patients with Type 2 Diabetes and Comorbid Rheumatoid Arthritis: A Target-Trial Emulation
Category: Endocrinology
Within-Person Seasonal Variability of Aminotransferases and Long-Term Glycemic Control in Adults With Type 2 Diabetes (JDDM 85)
Background & aims: Aminotransferases are widely used for metabolic dysfunction-associated steatotic liver disease (MASLD) evaluation, especially in type 2 diabetes mellitus (T2DM). Whether within-person seasonal variation affects classification near commonly used thresholds or relates to long-term metabolic outcomes remains unclear.Methods: This registry-based cohort analysed monthly aspartate aminotransferase (AST) and alanine aminotransferase (ALT) measurements from 6039… Continue reading Within-Person Seasonal Variability of Aminotransferases and Long-Term Glycemic Control in Adults With Type 2 Diabetes (JDDM 85)
Association of HbA1c levels with neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in patients with diabetes mellitus: a case-control study
Background: The prevalence of diabetes mellitus in the general population has been increasing in recent years, and diabetes-related complications contribute substantially to morbidity, mortality, and healthcare system burden. This study aimed to evaluate the relationship between glycated hemoglobin (HbA1c) levels and inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR),… Continue reading Association of HbA1c levels with neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in patients with diabetes mellitus: a case-control study
A Systematic Review of Herbal Medicines in the Management of Diabetes: Efficacy, Toxicological Profiles, and Clinical Safety Considerations
#Diabetes mellitus and #prediabetes represent major global health challenges associated with metabolic and cardiovascular complications. This review was conducted to evaluate herbal medicines as complementary strategies for glycaemic control and metabolic risk reduction. This systematic review assessed the efficacy, metabolic and cardiovascular effects, and clinical safety of herbal medicines used in diabetes and prediabetes management.… Continue reading A Systematic Review of Herbal Medicines in the Management of Diabetes: Efficacy, Toxicological Profiles, and Clinical Safety Considerations
Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer
Importance: Patients with #breast cancer (BC) with comorbid #obesity or type 2 #diabetes (T2D) experience poorer survival. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are approved to treat these comorbidities; however, their associations with BC survival and recurrence remain unclear.Objective: To evaluate the association between GLP-1 RA use and 10-year all-cause mortality and recurrence-free survival (RFS)… Continue reading Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer
Type 2 Diabetes and the Lung – Cause and Consequence
Purpose of review: The purpose of this review is to synthesize literature investigating the relationship between type 2 #diabetes (T2D) and obstructive airway diseases and to identify implications for clinical care.Recent findings: Type 2 diabetes is a common and challenging comorbidity in patients with #asthma and chronic obstructive pulmonary disease (#COPD ). Basic, translational and… Continue reading Type 2 Diabetes and the Lung – Cause and Consequence
Clinical Predictors and Histopathological Spectrum of Nondiabetic Kidney Disease in Type 2 Diabetes
Introduction: When a patient's presentation raises suspicions for conditions other than diabetic kidney disease (DKD), such as sudden onset proteinuria <5 years after the onset of type 2 diabetes, proteinuria without retinopathy or neuropathy, acute kidney injury, active urinary sediment, or hematuria, clinically indicated kidney biopsies are typically carried out. Consequently, a high incidence of… Continue reading Clinical Predictors and Histopathological Spectrum of Nondiabetic Kidney Disease in Type 2 Diabetes
Muscle glycogen metabolism is rapidly dysregulated in critical illness, which may have implications for muscle ATP resynthesis and ICU acquired weakness
The association of perturbed skeletal muscle metabolism with #ICU acquired weakness (ICUAW) is not clear. The objective of the present study was to characterise temporal changes in skeletal #muscle mitochondrial function, #ATP concentration, and substrate utilisation during and up to 6 months post ICU admission in critically ill patients, and to delineate mechanisms underpinning ICUAW… Continue reading Muscle glycogen metabolism is rapidly dysregulated in critical illness, which may have implications for muscle ATP resynthesis and ICU acquired weakness
Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the ABC Model
Aims: We evaluated the impact of scenario-based multifactorial control on the 3-year incidence of fatal/non-fatal cardiovascular disease (#CVD ) and associated healthcare costs in Asian patients with type 2 diabetes (#T2D ).Materials and methods: We applied the validated 'ABC' model to simulate the 3-year impact of attaining multiple treatment targets (HbA1c < 7%, blood pressure… Continue reading Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the ABC Model
