In 2016, a case of seborrheic keratosis was successfully treated with diclofenac gel 3%. Diclofenac gel mechanism of action is most likely through induction of apoptosis. This study included 30 patients with multiple seborrheic keratosis. One lesion was treated with topical diclofenac sodium gel 1% and another lesion with topical ibuprofen gel applied twice daily… Continue reading Comparative evaluation of topical diclofenac sodium vs topical Ibuprofen in the treatment of #seborrheic keratosis.
Category: Dermatology
Use of #beta-blockers for #rosacea-associated facial erythema and flushing: A systematic review and update on proposed mode of action
Flushing and erythema are frequent skin symptoms in rosacea. Because their adequate treatment remains a clinical challenge, new treatment options are explored, such as oral β-blockers.. ..Nine studies evaluating the use of carvedilol, propranolol, nadolol, and β-blockers in general were included. Articles studying carvedilol and propranolol showed a large reduction of erythema and flushing during… Continue reading Use of #beta-blockers for #rosacea-associated facial erythema and flushing: A systematic review and update on proposed mode of action
Association Between Oral Corticosteroid Bursts and Severe Adverse Events
Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown.. .. Background: Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown. Objective: To examine the associations between steroid bursts and… Continue reading Association Between Oral Corticosteroid Bursts and Severe Adverse Events
#Acne vulgaris and risk of #depression and #anxiety: A meta-analytic review
Several studies have shown an association of acne vulgaris with depression and anxiety, but a quantitative review has not yet been conducted.. Forty-two studies were included. We found a significant association of acne vulgaris with depression ( r = 0.22 [95% confidence interval 0.17-0.26, P < .00001]) and anxiety ( r = 0.25 [95% confidence… Continue reading #Acne vulgaris and risk of #depression and #anxiety: A meta-analytic review
Prevalence, Incidence, and Risk of Cancer in Patients With #Psoriasis and Psoriatic Arthritis A Systematic Review and Meta-analysis
..There was an increased risk of several cancers, including keratinocyte cancer (RR, 2.28; 95% CI, 1.73-3.01), lymphomas (RR, 1.56; 95% CI, 1.37-1.78), lung cancer (RR, 1.26; 95% CI, 1.13-1.40), and bladder cancer (RR, 1.12; 95% CI, 1.04-1.19). No increased risk of cancer for patients with psoriasis treated with biologic agents was found (RR, 0.97; 95%… Continue reading Prevalence, Incidence, and Risk of Cancer in Patients With #Psoriasis and Psoriatic Arthritis A Systematic Review and Meta-analysis
#Skin barrier damage after exposure to para-phenylenediamine
p-Phenylenediamine (#PPD) is a strong contact allergen used in hair dye known to cause allergic contact dermatitis (ACD). Both private and occupational exposure to PPD is frequent, but the effect of PPD exposure in non-allergic occupational exposed individuals is unknown.. ..RNA-sequencing demonstrated down-regulation of tight junction (TJ) and stratum corneum (SC) proteins in skin of… Continue reading #Skin barrier damage after exposure to para-phenylenediamine
#Atopic eczema and #fracture risk in adults: A population-based cohort study
..Those with eczema had increased risk of hip (HR, 1.10; 99% CI, 1.06-1.14), pelvic (HR, 1.10; 99% CI, 1.02-1.19), spinal (HR, 1.18; 99% CI, 1.10-1.27), and wrist (HR, 1.07; 99% CI, 1.03,-1.11) fractures. We found no evidence of increased proximal humeral (HR, 1.06; 99% CI, 0.97-1.15) fracture risk. Fracture risk increased with increasing eczema severity,… Continue reading #Atopic eczema and #fracture risk in adults: A population-based cohort study
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