Interleukin (IL)-31 affects the inflammatory response, is involved in epidermal barrier disruption in atopic dermatitis (AD) and plays a key role in pruritus. Nemolizumab, a humanized monoclonal antibody against IL-31 receptor A, reduced pruritus in patients with AD after a 16-week administration period. ObjectivesTo examine the long-term effectiveness and safety of nemolizumab in patients aged… Continue reading Nemolizumab plus topical agents in patients with atopic dermatitis (AD) and moderate-to-severe pruritus provide improvement in pruritus and signs of AD for up to 68 weeks: results from two phase III, long-term studies
Category: Dermatology
Role of nutritional supplements in selected dermatological disorders: A review
While a plethora of literature continues to be published on the role of nutritional agents both in lay press and indexed journals, the data is not on a firm footing and leaves the dermatologist in a quandry and the patient confused. The various agents include vitamins, minerals, amino acids, antioxidants, diets & gluten. A proper… Continue reading Role of nutritional supplements in selected dermatological disorders: A review
Trial of Spesolimab for Generalized Pustular Psoriasis
Generalized pustular psoriasis (GPP) is a rare, life-threatening, inflammatory skin disease characterized by widespread eruption of sterile pustules. Interleukin-36 signaling is involved in the pathogenesis of this disorder. Spesolimab, a humanized anti–interleukin-36 receptor monoclonal antibody, is being studied for the treatment of GPP flares. In a phase 2 trial, we randomly assigned patients with a… Continue reading Trial of Spesolimab for Generalized Pustular Psoriasis
Charting host-microbe co-metabolism in #skin #aging and application to metagenomics data
During aging of human skin, a number of intrinsic and extrinsic factors cause the alteration of the skin’s structure, function and cutaneous physiology. Many studies have investigated the influence of the skin microbiome on these alterations, but the molecular mechanisms that dictate the interplay between these factors and the skin microbiome are still not fully… Continue reading Charting host-microbe co-metabolism in #skin #aging and application to metagenomics data
Association Between #Melanoma Detected During Routine Skin Checks and Mortality
Are melanomas diagnosed through routine skin checks (a proxy for skin cancer screening) associated with reduced melanoma-specific and all-cause mortality? Findings This population-based cohort study included 2452 patients, each with 1 diagnosed melanoma, 35% of which were detected during a routine skin check. In multivariable analyses, routine skin-check detection was associated with a subhazard ratio… Continue reading Association Between #Melanoma Detected During Routine Skin Checks and Mortality
Prevalence and Associated Diseases of #Seborrheic Skin in Adults
Seborrhea is a skin condition characterized by abundant production of sebum associated with typical dermatological conditions such as rosacea and acne. Little is known about the prevalence of seborrhea and the frequency of concurrent skin diseases in the general population. Objective: To investigate the epidemiology and comorbidity of seborrhea in the adolescent and adult working… Continue reading Prevalence and Associated Diseases of #Seborrheic Skin in Adults
Vitamin #C and scar strength: analysis of a historical trial and implications for #collagen-related pathologies
A double-blind controlled trial initiated in 1944 has led to the common narrative that a 10-mg daily vitamin C intake is adequate to prevent and treat impaired wound healing, and by inference, other collagen-related diseases such as heart disease or stroke. The WHO relies on this narrative to set the recommended nutrient intake for vitamin… Continue reading Vitamin #C and scar strength: analysis of a historical trial and implications for #collagen-related pathologies
Topical 5% #Tranexamic acid with 30% #Glycolic acid peel: An useful Combination for Accelerating the improvement in #Melasma
Recently, topical Tranexamic acid (TXA) has been used in melasma management. On detail search of literature, this may be the first study assessing efficacy on combining of Topical TXA with GA peel in melasma. To assess efficacy, safety and improvement in quality of life index on combining 30% GA peel with 5% TXA solution topically… Continue reading Topical 5% #Tranexamic acid with 30% #Glycolic acid peel: An useful Combination for Accelerating the improvement in #Melasma
Prevalence of Nonradiographic #Sacroiliitis in Patients With Psoriatic #Arthritis: A Real-life Observational Study
To establish the prevalence of nonradiographic sacroiliitis within a real-life sample of patients with psoriatic arthritis (PsA), using pelvic radiographs and magnetic resonance imaging (MRI) of sacroiliac joints (SIJs). Methods. This cross-sectional study included 107 consecutive adults with PsA (Classification Criteria for Psoriatic Arthritis criteria). Participants completed clinical and laboratory evaluation, pelvic radiographs scored for… Continue reading Prevalence of Nonradiographic #Sacroiliitis in Patients With Psoriatic #Arthritis: A Real-life Observational Study
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