Dear Editor, We report a case of an 80-year-old man who came to our attention for a rapidly progressive loss of facial hair 7 days after the administration of the first dose of the BNT162b2 vaccine, an mRNA vaccine against SARS-CoV-2. He had no personal or family history of alopecia or autoimmunity. Before the vaccination, a… Continue reading Alopecia areata following COVID-19 vaccination: vaccine-induced autoimmunity?
Category: Dermatology
Eczema is a shared risk factor for anxiety and depression: A meta-analysis and systematic review
Globally, anxiety and depression are the most common psychiatric disorders that add large burdens to individuals and society; however, the mechanisms underlying these disorders are unclear. Several studies have found that eczema is a shared risk factor for both these conditions. We identified and evaluated eligible observational studies from EMBASE and PubMed. In total, 20… Continue reading Eczema is a shared risk factor for anxiety and depression: A meta-analysis and systematic review
Two Phase 3 Trials of Baricitinib for Alopecia Areata
BACKGROUNDAlopecia areata is an autoimmune condition characterized by rapid hair loss in the scalp, eyebrows, and eyelashes, for which treatments are limited. Baricitinib, an oral, selective, reversible inhibitor of Janus kinases 1 and 2, may interrupt cytokine signaling implicated in the pathogenesis of alopecia areata. METHODSWe conducted two randomized, placebo-controlled, phase 3 trials (BRAVE-AA1 and… Continue reading Two Phase 3 Trials of Baricitinib for Alopecia Areata
New-onset of vitiligo in a child following COVID-19 vaccination
Since January 2020, the ongoing COVID-19 pandemic has been a global health emergency. Vaccination is a critical measure for containing the spread of COVID-19. At the end of 2020, several vaccines became available. Multiple adverse events (AEs) have been reported with all the available COVID-19 vaccines. This report describes a case of vitiligo in a… Continue reading New-onset of vitiligo in a child following COVID-19 vaccination
Association of Cardiac Biomarkers with Cardiovascular Outcomes in Patients with Psoriatic Arthritis and Psoriasis: A Longitudinal Cohort Study
In patients with psoriatic disease (PsD), we determined whether cardiac troponin I (cTnI) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) were associated with carotid plaque burden and the development of cardiovascular (CV) events independent of the Framingham Risk Score (FRS). MethodsAmong 1,000 patients with PsD, carotid total plaque area (TPA) was measured in 358 participants at… Continue reading Association of Cardiac Biomarkers with Cardiovascular Outcomes in Patients with Psoriatic Arthritis and Psoriasis: A Longitudinal Cohort Study
Efficacy of botulinum toxin A injection in the treatment of androgenic alopecia: A Comparative Controlled Study
IntroductionScalp injection with mesotherapy (LC cell hair essence) helps in anchoring hair follicles and might have good therapeutic efficacy and lower side effects than Botox in the treatment of androgenetic alopecia (AGA). ObjectiveTo assess the trichoscopy and the clinical therapeutic response of LC hair essence serum injection vs. botulinum toxin (A) injection in the treatment… Continue reading Efficacy of botulinum toxin A injection in the treatment of androgenic alopecia: A Comparative Controlled Study
How effective are interventions to reduce Staphylococcus aureus in eczema?
Key messagesEczema is commonly colonized by Staphylococcus aureus so some advocate antibiotics or dilute bleach baths. This Cochrane review evaluated trials of anti-staph treatments in people with infected or uninfected eczema. From 41 trials (1753 participants), there was little evidence that these interventions impact eczema symptoms. ... 2.7 Authors’ conclusionsWe found insufficient evidence on the… Continue reading How effective are interventions to reduce Staphylococcus aureus in eczema?
Ketoconazole 2% Cream Alters the Skin Fungal Microbiome in Seborrheic Dermatitis: a Cohort Study
Seborrheic dermatitis (SD) is a common chronic inflammatory dermatosis. Current theories highlight the role of microbes on the skin surface in the pathogenesis of SD. Ketoconazole is commonly used for the treatment of SD. However, there remains limited data focusing on the effects of ketoconazole on shaping the skin microbiome in patients with SD. ObjectiveIn… Continue reading Ketoconazole 2% Cream Alters the Skin Fungal Microbiome in Seborrheic Dermatitis: a Cohort Study
Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers
Janus kinase (JAK) inhibitors have shown encouraging results in the treatment of alopecia areata (AA), an autoimmune form of hair loss, in small, uncontrolled studies and case reports. ObjectiveWe conducted a biopsy substudy during the randomized, double-blind, placebo-controlled first 24 weeks of a phase 2a clinical trial that evaluated the efficacy and safety of ritlecitinib,… Continue reading Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers
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