Objective: In this study we evaluated associations between nutritional factors, including calcium supplementation, and outcomes of fracture and cardiovascular mortality. We chose to report both outcomes as an illustration of the importance of nutritional factors in midlife to heart disease as this may be more impactful for supporting behavior change strategies, particularly in men.Methods: This… Continue reading 60 is the new 40: preparing for better bone #health in later life
Category: Cardiology
Intestinal #Microbiota Contributes to the Development of #Cardiovascular Inflammation and Vasculitis in Mice
Alterations in the intestinal microbiota contribute to the pathogenesis of various cardiovascular disorders, but how they affect the development of Kawasaki disease (KD) an acute pediatric vasculitis, remains unclear.METHODS:We used the Lactobacillus casei cell wall extract (LCWE) murine model of KD vasculitis to assess the contribution of the intestinal microbiota to the development of vascular… Continue reading Intestinal #Microbiota Contributes to the Development of #Cardiovascular Inflammation and Vasculitis in Mice
Share onGlobal Effect of #Cardiovascular Risk Factors on Lifetime Estimates
Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear.MethodsWe harmonized individual-level data from 2,078,948 participants across 133 cohorts, 39 countries, and 6 continents. Lifetime risk of cardiovascular disease… Continue reading Share onGlobal Effect of #Cardiovascular Risk Factors on Lifetime Estimates
Association of Accelerometer‐Derived #Physical Activity Pattern With the Risks of All‐Cause, #Cardiovascular Disease, and Cancer Death
Current guidelines suggest engaging in a minimum of 150 minutes of moderate to vigorous physical activity (MVPA) each week to support overall health. However, the effect of concentrated versus evenly distributed physical activity (PA) on health outcomes remains uncertain. This study aims to investigate the associations of “weekend warrior” pattern, where most MVPA is completed… Continue reading Association of Accelerometer‐Derived #Physical Activity Pattern With the Risks of All‐Cause, #Cardiovascular Disease, and Cancer Death
The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Introduction: Vaccine-related myocarditis is recognized as a rare but important complication, especially after mass-scale mRNA COVID-19 vaccination. Knowledge regarding how to minimize the risk is limited. As NK cells can mediate acute myocarditis after mRNA COVID-19 vaccination and vitamin D may inhibit NK cells via cytokine modulation, we hypothesize that the myocarditis side effect is… Continue reading The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Associations Between #Polyphenol Intake, Cardiometabolic Risk Factors and Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)Author links open overlay panel
BackgroundFruit- and vegetable-rich diets may protect against metabolic syndrome (MetS), partly due to their high polyphenol content.ObjectivesThis study examined the association between dietary polyphenol intake, MetS risk, and cardiometabolic factors in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).MethodsA total of 6387 participants (mean age 49.8 y, 65% female) were included. Food intake was assessed… Continue reading Associations Between #Polyphenol Intake, Cardiometabolic Risk Factors and Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)Author links open overlay panel
Long-term survival and durable recovery of #heart failure in patients with triglyceride deposit #cardiomyovasculopathy treated with tricaprin
Heart disease is a major global threat. Triglyceride deposit cardiomyovasculopathy (TGCV) is an emerging, noncommunicable, adult-onset heart disease, first identified in Japanese patients with heart failure (HF) requiring cardiac transplantation1,2,3. In TGCV, defective intracellular lipolysis of long-chain triglycerides (TGs) results in cellular steatosis and energy failure mainly in cardiomyocytes4 and smooth muscle cells5, leading to… Continue reading Long-term survival and durable recovery of #heart failure in patients with triglyceride deposit #cardiomyovasculopathy treated with tricaprin
Effect of #sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial
Sodium–glucose co-transporter (SGLT)-2 inhibitors have shown consistent benefit in improving heart failure-related outcomes but not ischaemic cardiovascular events such as myocardial infarction or stroke. We assessed if the dual SGLT1/2 inhibitor sotagliflozin improves ischaemic outcomes.MethodsWe did a prespecified secondary analysis of the SCORED trial, which was a double-blind, placebo-controlled, randomised clinical trial enrolling patients (aged… Continue reading Effect of #sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial
#Retinal vascular fingerprints predict incident #stroke: findings from the UK Biobank cohort study
Objective To investigate the associations between a comprehensive set of retinal vascular parameters and incident stroke to unveil new associations and explore its predictive power for stroke risk.Methods Retinal vascular parameters were extracted from the UK Biobank fundus images using the Retina-based Microvascular Health Assessment System. We used Cox regression analysis, adjusted for traditional risk… Continue reading #Retinal vascular fingerprints predict incident #stroke: findings from the UK Biobank cohort study
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