Highlights•The regular consumption of moderate doses of coffee attenuates all-cause mortality•Coffee intake attenuates age-associated diseases (cardiovascular, stroke, cancer)•Coffee and its main components (caffeine, chlorogenic acids) control stress adaptation•Coffee intake preserves the main biological mechanisms of aging AbstractThe conception of coffee consumption has undergone a profound modification, evolving from a noxious habit into a safe lifestyle… Continue reading Impact of #coffee intake on human #aging: Epidemiology and cellular mechanisms
Category: Aging
#LEVOTHYROXINE USE AND #BONE LOSS IN #EUTHYROID #OLDER ADULTS: A LONGITUDINAL ANALYSIS FROM BALTIMORE LONGITUDINAL STUDY OF AGING | S3B-SPMS-1
Purpose: Levothyroxine (LT4) is the second most commonly prescribed medication in older adults. Frank hyperthyroidism accelerates bone turnover and even subclinical hyperthyroid has been associated with increased fracture risk. Data indicates that a significant proportion of thyroid hormone prescriptions may be given to older adults without hypothyroidism raising concerns about subsequent relative excess of thyroid… Continue reading #LEVOTHYROXINE USE AND #BONE LOSS IN #EUTHYROID #OLDER ADULTS: A LONGITUDINAL ANALYSIS FROM BALTIMORE LONGITUDINAL STUDY OF AGING | S3B-SPMS-1
#Physical activity and life #expectancy: a life-table analysis
Objective Low physical activity (PA) levels are associated with increased mortality. Improved measurement has resulted in stronger proven associations between PA and mortality, but this has not yet translated to improved estimates of the disease burden attributable to low PA. This study estimated how much low PA reduces life expectancy, and how much life expectancy… Continue reading #Physical activity and life #expectancy: a life-table analysis
Ultra-processed #food consumption is associated with the acceleration of biological #aging in the Moli-sani Study
BackgroundHealthy diets have been inversely associated with biological aging. However, the nutritional content is only one aspect of the overall food health potential, and more recently, increasing attention has been paid to nonnutrient food characteristics, such as food processing.ObjectivesTo examine the association of ultra-processed food (UPF) consumption with biological aging measured by circulating blood biomarkers.MethodsCross-sectional… Continue reading Ultra-processed #food consumption is associated with the acceleration of biological #aging in the Moli-sani Study
Association of Self-Reported #Sleep Characteristics With Neuroimaging Markers of Brain #Aging Years Later in Middle-Aged Adults
ObjectivesTo determine the association between early midlife sleep and advanced brain aging patterns in late midlife.MethodsUsing the CARDIA study, we analyzed sleep data at baseline and 5 years later, focusing on short sleep duration, bad sleep quality (SQ), difficulty initiating and maintaining sleep (DIS and DMS), early morning awakening (EMA), and daytime sleepiness. These were… Continue reading Association of Self-Reported #Sleep Characteristics With Neuroimaging Markers of Brain #Aging Years Later in Middle-Aged Adults
#Dietary restriction impacts health and #lifespan of genetically diverse mice
Caloric restriction extends healthy lifespan in multiple species1. Intermittent fasting, an alternative form of dietary restriction, is potentially more sustainable in humans, but its effectiveness remains largely unexplored2,3,4,5,6,7,8. Identifying the most efficacious forms of dietary restriction is key for developing interventions to improve human health and longevity9. Here we performed an extensive assessment of graded… Continue reading #Dietary restriction impacts health and #lifespan of genetically diverse mice
#CheekAge, a next-generation epigenetic buccal clock, is predictive of mortality in human blood
While earlier first-generation epigenetic aging clocks were trained to estimate chronological age as accurately as possible, more recent next-generation clocks incorporate DNA methylation information more pertinent to health, lifestyle, and/or outcomes. Recently, we produced a non-invasive next-generation epigenetic clock trained using Infinium MethylationEPIC data from more than 8,000 diverse adult buccal samples. While this clock… Continue reading #CheekAge, a next-generation epigenetic buccal clock, is predictive of mortality in human blood
Risk of #Dementia Diagnosis After Injurious #Falls in Older Adults
Importance Emerging evidence suggests that mild cognitive impairment, which is a precursor to Alzheimer disease and related dementias (ADRD), places older adults at increased risk for falls. However, the risk that an older adult develops dementia after experiencing a fall is unknown.Objective To determine the risk of new ADRD diagnosis after a fall in older… Continue reading Risk of #Dementia Diagnosis After Injurious #Falls in Older Adults
#Metformin decelerates #aging clock in male monkeys
Highlights•Metformin prevents brain atrophy, elevating cognitive function in aged male primates.Metformin slows the pace of aging across diverse male primate tissues•Metformin counterparts neuronal aging, delivering geroprotection via Nrf2 in male primatesSummaryIn a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The… Continue reading #Metformin decelerates #aging clock in male monkeys
2 Medical News 