Intestinal #Microbiota Contributes to the Development of #Cardiovascular Inflammation and Vasculitis in Mice

Alterations in the intestinal microbiota contribute to the pathogenesis of various cardiovascular disorders, but how they affect the development of Kawasaki disease (KD) an acute pediatric vasculitis, remains unclear.METHODS:We used the Lactobacillus casei cell wall extract (LCWE) murine model of KD vasculitis to assess the contribution of the intestinal microbiota to the development of vascular… Continue reading Intestinal #Microbiota Contributes to the Development of #Cardiovascular Inflammation and Vasculitis in Mice

Atypical Kawasaki Disease after COVID-19 Vaccination: A NewForm of Adverse Event Following Immunization

Abstract: Kawasaki disease (KD) is a medium-vessel vasculitis that is typically presented duringchildhood; fewer than 100 cases of KD have been reported worldwide in adult patients who metthe criteria according to the American College of Rheumatology. This study presents the case ofan 18-year-old patient with no previous history of any disease, who presented atypical KD… Continue reading Atypical Kawasaki Disease after COVID-19 Vaccination: A NewForm of Adverse Event Following Immunization

Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning

Our group has been using the PLUS Cardiac Test (GD Biosciences, Inc, Irvine, CA) a clinically validated measurement of multiple protein biomarkers which generates a score predicting the 5 yr risk (percentage chance) of a new Acute Coronary Syndrome (ACS). The score is based on changes from the norm of multiple protein biomarkers including IL-16,… Continue reading Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning

Immune mediated events timely associated with COVID-19 vaccine. A comment on article by Badier, et al.: “IgA vasculitis in adult patients following vaccination by ChadOx1 nCoV-19”

Dear Editor,We read the article by Badier et al. entitled “IgA vasculitis in adult patients following vaccination by ChadOx1 nCoV-19”, published in Autoimmunity Reviews with interest. (1) We share the author's view that the COVID-19 vaccine could be the trigger of IgA vasculitis in the reported case. At our secondary/tertiary rheumatology centre, we have been… Continue reading Immune mediated events timely associated with COVID-19 vaccine. A comment on article by Badier, et al.: “IgA vasculitis in adult patients following vaccination by ChadOx1 nCoV-19”

Association of #Cigarette Smoking With Antineutrophil Cytoplasmic Antibody–Associated #Vasculitis

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic small vessel vasculitis characterized by circulating ANCAs targeting proteinase 3 (PR3) or myeloperoxidase (MPO) and associated with excess morbidity and mortality. Myeloperoxidase-ANCA–positive AAV and PR3-ANCA–positive AAV are increasingly recognized to have differences in genetic risk, pathogenesis, and response to treatment. Risk factors for AAV, including cigarette… Continue reading Association of #Cigarette Smoking With Antineutrophil Cytoplasmic Antibody–Associated #Vasculitis