Serum microRNA analysis facilitates decision-making between active surveillance and immediate surgery for low-risk #thyroid #tumors

Objective: To develop a practical and cost-effective test to distinguish patients with malignant thyroid nodules eligible for active surveillance from those requiring immediate surgery.Methods: This prospective observational study included patients with malignant thyroid nodules (3 to 15 mm) who were assigned to either an Active Surveillance Group (n = 30) or a Surgery Group (n… Continue reading Serum microRNA analysis facilitates decision-making between active surveillance and immediate surgery for low-risk #thyroid #tumors

Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients

BackgroundWe aimed to examine sex-specific associations between sex- and thyroid-related hormones and the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in patients with type 2 diabetes mellitus (T2DM)MethodsCross-sectional analyses of baseline information from an ongoing cohort of 432 T2DM patients (185 women and 247 men) in Xiamen, China were conducted. Plasma sex-related hormones, including… Continue reading Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients

Hypo- and hyper- #thyroidism: algorithm for screening and diagnosis

Screening, diagnosing, and managing hypothyroidism: ATA/AACE guidelines recommend screening for all patients with symptoms of hypothyroidism. For patients whoare asymptomatic, recommendations vary widely. However, a thyroid-stimulating hormone (TSH) test is generallyrecommended for patients ≥50–60 years old, especially women. Guidelines also state that there is compelling evidence to support screening in patients with: Hypothyroidism: algorithm for… Continue reading Hypo- and hyper- #thyroidism: algorithm for screening and diagnosis

Thyroiditis after Coronavirus Disease 2019 (COVID-19) mRNA Vaccine: A Case Series

Highlights1)Thyrotoxicosis with palpitation, and neck tenderness is the most common presentation of thyroiditis. The patients with new onset of thyrotoxicosis should be asked about history of mRNA-vaccine injection for the possible etiology. 2)mRNA vaccine induced thyroiditis could occur 10-20 days after the first dose or the second dose. 3)Management is to relieve the symptom of… Continue reading Thyroiditis after Coronavirus Disease 2019 (COVID-19) mRNA Vaccine: A Case Series

Association of Metabolic Health and Central Obesity With the Risk of Thyroid Cancer: Data from the Korean Genome and Epidemiology Study

Background:It is unknown whether the risk of thyroid cancer differs among metabolically healthy/unhealthy, normal-weight, or obese women. We aimed to assess the association of metabolic health and obesity with thyroid cancer risk. Methods:The Korean Genome and Epidemiology Study is a population-based prospective cohort study. Data were obtained from 173,343 participants (age {greater than or equal… Continue reading Association of Metabolic Health and Central Obesity With the Risk of Thyroid Cancer: Data from the Korean Genome and Epidemiology Study

Thyroid as a target of adjuvant autoimmunity/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves’ disease to silent thyroiditis

BackgroundAs COVID-19 became a pandemic, the urgent need to find an effective treatment vaccine has been a major objective. Vaccines contain adjuvants which are not exempt from adverse effects and can trigger the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). There is very little information about autoimmune endocrine disease and the ASIA after the use of… Continue reading Thyroid as a target of adjuvant autoimmunity/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves’ disease to silent thyroiditis

Evidence of a Causal Relationship between Serum #Thyroid-Stimulating Hormone and #Osteoporotic Bone Fractures

We aimed to validate the association of genome-wide association study (GWAS)-identified loci and polygenic risk score with serum thyroid-stimulating hormone (TSH) concentrations and the diagnosis of hypothyroidism. Then, the causal relationship between serum TSH and osteoporotic bone fracture risk was tested. Methods: A cross-sectional study was done among patients of European Caucasian ethnicity recruited in… Continue reading Evidence of a Causal Relationship between Serum #Thyroid-Stimulating Hormone and #Osteoporotic Bone Fractures