Our current understanding of immunity to pathogens suggests that anatomic coupling of antigens with danger signals is a required feature for the formation of immune memory. However, in the context of pathogen-independent inflammation, the stringency of this anatomical coupling is unclear. Here, we demonstrate that multiple modes of skin injury were sufficient to induce a… Continue reading #Skin damage signals mediate #allergic sensitization to spatially unlinked antigen
Tag: Food
Are Foods with #Protein Claims Healthy? A Study of the Spanish Market
Background: Foods with protein claims (PCs) targeted at the general population are increasingly sought after by consumers because they think they are healthy. However, they may contain other nutrients that pose a health risk. Objectives: Therefore, the aim of this work was to carry out a comprehensive evaluation of foods with PC and compare them… Continue reading Are Foods with #Protein Claims Healthy? A Study of the Spanish Market
Proteomic predictors of individualized nutrient-specific #insulin secretion in #health and #disease
Insulin secretion to 3 model macronutrients in 140 human islet donors is defined•Deep phenotyping and multi-omics reveal personalized nutrient-specific insulin release•A subset of donors with a unique proteome exhibits large insulin responses to lipids•Nutrient responsiveness in stem cell-derived islets is dysregulatedSummaryPopulation-level variation and mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain… Continue reading Proteomic predictors of individualized nutrient-specific #insulin secretion in #health and #disease
Association of ultra-processed #food consumption with all cause and cause specific #mortality: population based cohort study
Objective To examine the association of ultra-processed food consumption with all cause mortality and cause specific mortality.Design Population based cohort study.Setting Female registered nurses from 11 US states in the Nurses’ Health Study (1984-2018) and male health professionals from all 50 US states in the Health Professionals Follow-up Study (1986-2018).Participants 74 563 women and 39 501 men with no history of… Continue reading Association of ultra-processed #food consumption with all cause and cause specific #mortality: population based cohort study
Food #additive emulsifiers and the risk of type 2 #diabetes: analysis of data from the NutriNet-Santé prospective cohort study
Experimental studies have suggested potential detrimental effects of emulsifiers on gut microbiota, inflammation, and metabolic perturbations. We aimed to investigate the associations between exposures to food additive emulsifiers and the risk of type 2 diabetes in a large prospective cohort of French adults.MethodsWe analysed data from 104 139 adults enrolled in the French NutriNet-Santé prospective cohort… Continue reading Food #additive emulsifiers and the risk of type 2 #diabetes: analysis of data from the NutriNet-Santé prospective cohort study
Lac-Phe mediates the effects of #metformin on #food intake and body weight
Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. There is ongoing debate about the mechanisms that mediate metformin’s effects on energy balance. Here, we show that metformin is a powerful pharmacological inducer of the anorexigenic metabolite N-lactoyl-phenylalanine (Lac-Phe) in cells, in mice and two independent human cohorts. Metformin drives Lac-Phe biosynthesis through… Continue reading Lac-Phe mediates the effects of #metformin on #food intake and body weight
Ultra-processed #food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses
AbstractObjective To evaluate the existing meta-analytic evidence of associations between exposure to ultra-processed foods, as defined by the Nova food classification system, and adverse health outcomes.Design Systematic umbrella review of existing meta-analyses.Data sources MEDLINE, PsycINFO, Embase, and the Cochrane Database of Systematic Reviews, as well as manual searches of reference lists from 2009 to June 2023.Eligibility criteria for… Continue reading Ultra-processed #food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses
Dietary #circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohort
Dietary circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohortDaily eating/fasting cycles synchronise circadian peripheral clocks, involved in the regulation of the cardiovascular system. However, the associations of daily meal and fasting timing with cardiovascular disease (CVD) incidence remain unclear. We used data from 103,389 adults in the NutriNet-Santé study. Meal timing and… Continue reading Dietary #circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohort
Consumption of ultra-processed #foods and risk of multimorbidity of #cancer and #cardiometabolic diseases: a multinational cohort study
It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and… Continue reading Consumption of ultra-processed #foods and risk of multimorbidity of #cancer and #cardiometabolic diseases: a multinational cohort study
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