Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality. Generalised—particularly nocturnal—convulsive seizures, longstanding epilepsy, and solitary living have been identified retrospectively as risk factors. No definitive electroclinical biomarkers have been prospectively ascertained. This study aimed to identify SUDEP risk markers using multimodality data with long-term follow-up.MethodsThis prospective, multicentre, observational cohort study,… Continue reading Risk markers for sudden unexpected #death in #epilepsy: an observational, prospective, multicentre cohort study
Tag: epilepsy
Effectiveness of Seizure #Dogs for People With Severe Refractory #EpilepsyResults From the EPISODE Study
Background and ObjectivesThe aim of this study was to evaluate whether people living with severe medically refractory epilepsy (PSRE) benefit from a seizure dog.MethodsAn individual-level stepped-wedge randomized controlled trial was conducted. The study was conducted in the Netherlands among adults with daily to weekly seizures. All participants were included simultaneously (on June 1, 2019) while… Continue reading Effectiveness of Seizure #Dogs for People With Severe Refractory #EpilepsyResults From the EPISODE Study
PRAC recommends new measures to avoid #topiramate exposure in #pregnancy
Further restrictions on use; pregnancy prevention programme to be put in placeEMA’s safety committee (PRAC) recommends new measures to avoid exposure of children to topiramate-containing medicines in the womb, because the medicine may increase the risk of neurodevelopmental problems after exposure during pregnancy. Topiramate is already known to cause serious birth defects when used during… Continue reading PRAC recommends new measures to avoid #topiramate exposure in #pregnancy
Associations of #overweight and #obesity with drug-resistant #epilepsy
The group with epilepsy included in this study had a lower proportion of individuals with overweight and obesity than the general population (23.1% versus 42%) in 2015. However, the proportion of patients with obesity in the groups with DRE was significantly higher than that in the general population (17.9% versus 7.1%).•The J-shaped relationship between BMI… Continue reading Associations of #overweight and #obesity with drug-resistant #epilepsy
Effects of double-dose #statin therapy for the prevention of post- #stroke #epilepsy: A prospective clinical study
To determine treatment effects on the incidence of post-stroke epilepsy (PSE) using different doses of statin, a prospective hospital-based cohort study was designed to explore whether a double-dose statin treatment can better prevent the occurrence of PSE. Methods :A total of 1152 patients with newly diagnosed ischemic stroke admitted to our hospital from March to… Continue reading Effects of double-dose #statin therapy for the prevention of post- #stroke #epilepsy: A prospective clinical study
Incidence rates of severe #cutaneous adverse reactions due to anti #seizure medication: A nationwide study using health claims data in Korea
Antiseizure medications (ASMs) can rarely result in severe, sometimes fatal, cutaneous adverse reactions. To date, few studies have reported on the incidence rates (IRs) of severe cutaneous adverse reactions (SCARs) due to ASM use. This study aimed to determine the IRs of SCAR resulting from the use of seven commonly prescribed ASMs, carbamazepine (CBZ), phenytoin… Continue reading Incidence rates of severe #cutaneous adverse reactions due to anti #seizure medication: A nationwide study using health claims data in Korea
#Cognitive decline in older adults with #epilepsy: The Cardiovascular Health Study
Cognitive decline is a major concern for older adults with epilepsy. Whether and how much faster older adults with epilepsy experience cognitive decline beyond expected age‐related cognitive change remain unclear. We sought to estimate and compare rates of cognitive decline in older adults with and without epilepsy.. ..The rate of decline in 3MS was significantly… Continue reading #Cognitive decline in older adults with #epilepsy: The Cardiovascular Health Study
Nine-year prospective efficacy and safety of brain-responsive #neurostimulation for focal #epilepsy
Prospectively evaluate safety and efficacy of brain-responsive neurostimulation in adults with medically intractable focal onset seizures (FOS) over 9 years.. Adults treated with brain-responsive neurostimulation within 2 year feasibility or randomized controlled trials enrolled into a long-term prospective open label trial (LTT) to assess safety, efficacy, and quality of life (QOL) over an additional 7… Continue reading Nine-year prospective efficacy and safety of brain-responsive #neurostimulation for focal #epilepsy
Daily listening to Mozart reduces seizures in individuals with epilepsy: A randomized control study
Epilepsy is one of the most common neurological disorders . Many individuals continue to have seizures despite medical and surgical treatments, suggesting adjunctive management strategies are required. Promising effects of daily listening to Mozart on reducing seizure frequency in individuals with epilepsy have been demonstrated over the last 20 years, but not in a rigorously… Continue reading Daily listening to Mozart reduces seizures in individuals with epilepsy: A randomized control study
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