Clinical pathways are changing to incorporate support and appropriate follow-up for people to achieve remission of type 2 diabetes, but there is limited understanding of the prevalence of remission in current practice or patient characteristics associated with remission. Methods and findingsWe carried out a cross-sectional study estimating the prevalence of remission of type 2 diabetes… Continue reading Epidemiology of type 2 #diabetes remission in Scotland in 2019: A cross-sectional population-based study
Tag: Diabetes
#GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize #glycemia in diabetic mice
Skeletal muscle insulin resistance is a main defect in type 2 diabetes (T2D), which is associated with impaired function and content of glucose transporter type 4 (GLUT4). GLUT4 overexpression in skeletal muscle tissue can improve glucose homeostasis. Therefore, we created an engineered muscle construct (EMC) composed of GLUT4-overexpressing (OEG4) cells. The ability of the engineered… Continue reading #GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize #glycemia in diabetic mice
Incidence Rates and Predictors of Microvascular and Macrovascular Complications in Patients with Type 2 #Diabetes: Results from the Longitudinal Global DISCOVER Study
In a global prospective study of patients with relatively early-stage diabetes, microvascular and macrovascular complications were common and were associated with increased risk of subsequent hospitalization and death. •The strongest predictor of incident complications was the known atherosclerosis or heart failure at enrollment. •Poor glucose control and smoking were also associated with increased risk of… Continue reading Incidence Rates and Predictors of Microvascular and Macrovascular Complications in Patients with Type 2 #Diabetes: Results from the Longitudinal Global DISCOVER Study
Cardiovascular health, genetic predisposition, and lifetime risk of type 2 #diabetes
Data on the lifetime risk of type 2 diabetes (T2D) incidence across different cardiovascular health (CVH) categories are scarce. Moreover, it remains unclear whether a genetic predisposition modifies this association. Methods and resultsUsing data from the prospective population-based Rotterdam Study, a CVH score (body mass index, blood pressure, total cholesterol, smoking status, diet, and physical… Continue reading Cardiovascular health, genetic predisposition, and lifetime risk of type 2 #diabetes
Fasting plasma #glucose level in the range of 90 to 99 mg/dL and the risk of the onset of type 2 #diabetes: Population-based Panasonic cohort study 2
As the association between fasting glucose concentration from 90 to 99 mg/dL and the onset of type 2 diabetes is still controversial, we aimed to assess it in 37,148 Japanese individuals with normal plasma glucose concentration. Materials and MethodsThis long-term retrospective cohort study included individuals with medical checkup at Panasonic Corporation from 2008 to 2018.… Continue reading Fasting plasma #glucose level in the range of 90 to 99 mg/dL and the risk of the onset of type 2 #diabetes: Population-based Panasonic cohort study 2
Effects of #SGLT-2 inhibitors on serum #uric acid in patients with T2DM: A systematic review and network meta-analysis
The present study aims to determine the effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors on the serum uric acid (SUA) levels of patients with type 2 diabetes mellitus (T2DM) in Asia. MethodsPubMed, CENTRAL, Embase and Cochrane Library databases were searched for randomized controlled trials (RCTs) of SGLT-2 inhibitors in patients with T2DM up to July… Continue reading Effects of #SGLT-2 inhibitors on serum #uric acid in patients with T2DM: A systematic review and network meta-analysis
#Proteinuria as a Significant Predictive Factor for the Progression of Carotid Artery #Atherosclerosis in Non-Albuminuric Type 2 #Diabetes
The purpose of this study was to evaluate whether the urine protein to creatinine ratio (uPCR) has have clinical significance in relation to cardiovascular risk associated with carotid artery intima-media thickness (cIMT) progression, in subjects with type 2 diabetes and normoalbuminuria. MethodsIn this retrospective longitudinal study on T2D, we recruited 927 subjects with normoalbuminuria (urine… Continue reading #Proteinuria as a Significant Predictive Factor for the Progression of Carotid Artery #Atherosclerosis in Non-Albuminuric Type 2 #Diabetes
Association of #Statin Therapy Initiation With #Diabetes ProgressionA Retrospective Matched-Cohort Study
Statin therapy has been associated with increased insulin resistance; however, its clinical implications for diabetes control among patients with diabetes is unknown. Objective To assess diabetes progression after initiation of statin use in patients with diabetes. Design, Setting, and Participants This was a retrospective matched-cohort study using new-user and active-comparator designs to assess associations between… Continue reading Association of #Statin Therapy Initiation With #Diabetes ProgressionA Retrospective Matched-Cohort Study
#Aging and comorbidities influence the risk of hospitalization and mortality in #diabetic patients experiencing severe hypoglycemia
Severe hypoglycemia requiring access to the Emergency Department is more frequent in older patients with multiple comorbidities.•Risk of hospitalization and mortality within one year since the hypoglycemic event is higher in older frail patients.•Severe hypoglycemia could increase the cardiovascular risk and could be a marker of future cardiovascular events.•A less stringent glycemic control and the… Continue reading #Aging and comorbidities influence the risk of hospitalization and mortality in #diabetic patients experiencing severe hypoglycemia
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