Psychosocial stress (PSS) is a significant contributor of inflammation and CVD.• NLRP3 inflammasome activation amplifies inflammation in response to PSS.• ER stress is a key upstream mechanism that triggers NLRP3 inflammasome activation.• This study reveals mechanisms and targets to reduce inflammation caused by PSS. AbstractPsychosocial stress (PSS) affects all humans with different intensities and is… Continue reading Psychosocial #stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse #heart
Tag: CVD
Temporal Patterns in Out-of-Hospital #Cardiac #Arrest Incidence and Outcome
Question Is the incidence or outcome of out-of-hospital cardiac arrest (OHCA) changing over time overall or among important demographic or clinical groups?Findings In this cohort study including 25 118 individuals, temporal incidence patterns depended on rhythm and demographic characteristics, with some groups experiencing decrease, some increase, and others no change. In contrast, OHCA outcomes improved over… Continue reading Temporal Patterns in Out-of-Hospital #Cardiac #Arrest Incidence and Outcome
#Ultraprocessed or minimally processed diets following healthy dietary guidelines on #weight and cardiometabolic health: a randomized, crossover trial
Ultraprocessed food (UPF) consumption is associated with noncommunicable disease risk, yet no trial has assessed its health impact within the context of national dietary guidelines. In a 2 × 2 crossover randomized controlled feeding trial, 55 adults in England (body mass index ≥25 to <40 kg m−2, habitual UPF intake ≥50% kcal day−1) were provided with two 8-week ad libitum… Continue reading #Ultraprocessed or minimally processed diets following healthy dietary guidelines on #weight and cardiometabolic health: a randomized, crossover trial
Prospective associations of daily #step count and stepping intensity with overall and type-specific major adverse #cardiovascular events in people with #hypertension
To examine the dose-response associations of step count and stepping intensity with risk of cardiovascular mortality and incidence of heart failure (HF), myocardial infarction (MI), and stroke (major adverse cardiovascular events, MACE) in people with hypertension.Methods and resultsData were obtained from participants with established hypertension from the UK Biobank accelerometry sub-study. Participants wore a wrist-worn… Continue reading Prospective associations of daily #step count and stepping intensity with overall and type-specific major adverse #cardiovascular events in people with #hypertension
Trajectories of #Physical Activity Before and After #Cardiovascular Disease Events in CARDIA Participants
Importance Moderate to vigorous–intensity physical activity (MVPA) is essential for primary and secondary prevention of cardiovascular disease (CVD), but long-term patterns around CVD events remain underexplored.Objective To evaluate MVPA trajectories across adulthood, pre-CVD and post-CVD changes, and demographic variations.Design, Setting, and Participants Data were drawn from CARDIA (Coronary Artery Risk Development in Young Adults), a… Continue reading Trajectories of #Physical Activity Before and After #Cardiovascular Disease Events in CARDIA Participants
Daily #steps and #health outcomes in #adults: a systematic review and dose-response meta-analysis
BackgroundDespite the rapid increase in evidence from the past decade on daily steps and health-related outcomes, existing systematic reviews primarily focused on few outcomes, such as all-cause mortality. This study synthesised the prospective dose-response relationship between daily steps and health outcomes including all-cause mortality, cardiovascular disease, cancer, type 2 diabetes, cognitive outcomes, mental health outcomes,… Continue reading Daily #steps and #health outcomes in #adults: a systematic review and dose-response meta-analysis
Health effects associated with consumption of #processed #meat, #sugar -sweetened beverages and trans #fatty acids: a Burden of Proof study
Previous research suggests detrimental health effects associated with consuming processed foods, including processed meats, sugar-sweetened beverages (SSBs) and trans fatty acids (TFAs). However, systematic characterization of the dose–response relationships between these foods and health outcomes is limited. Here, using Burden of Proof meta-regression methods, we evaluated the associations between processed meat, SSBs and TFAs and… Continue reading Health effects associated with consumption of #processed #meat, #sugar -sweetened beverages and trans #fatty acids: a Burden of Proof study
Personal night #light exposure predicts incidence of #cardiovascular diseases in >88,000 individuals
Importance Light at night causes circadian disruption, which is a known risk factor for adverse cardiovascular outcomes. However, it is not well understood whether personal light exposure patterns predicts and individual’s risk of cardiovascular diseases.Objective To assess whether day and night light exposure predicts incidence of cardiovascular diseases, and whether relationships of light with cardiovascular… Continue reading Personal night #light exposure predicts incidence of #cardiovascular diseases in >88,000 individuals
The relationship between #polyunsaturated #fatty acids and #inflammation: evidence from cohort and Mendelian randomization analyses
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) are thought to have anti- and pro-inflammatory roles, respectively, and influence the risk of various chronic diseases. However, it is unclear whether these associations are causal.MethodsWe examined the associations of dietary polyunsaturated FAs with biomarkers of systemic inflammation: C-reactive protein (CRP), glycoprotein acetyls (GlycA), and interleukin… Continue reading The relationship between #polyunsaturated #fatty acids and #inflammation: evidence from cohort and Mendelian randomization analyses
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