..Our Pubmed search yielded 274 potential studies. After deduplication and application of the eligibility criteria, four studies with a total of 8,990 COVID-19 patients were included for meta-analysis. Except for Yan et al. which is of moderate quality (5/9), other studies are of good quality (at least 7/9). Study characteristics are provided in Table 1.… Continue reading Meta-analysis of Effectiveness of #Statins in Patients with Severe #COVID-19
Tag: coronavirus
Modeling the Onset of #Symptoms of #COVID-19
COVID-19 is a pandemic viral disease with catastrophic global impact. This disease is more contagious than influenza such that cluster outbreaks occur frequently. If patients with symptoms quickly underwent testing and contact tracing, these outbreaks could be contained. Unfortunately, COVID-19 patients have symptoms similar to other common illnesses. Here, we hypothesize the order of symptom… Continue reading Modeling the Onset of #Symptoms of #COVID-19
Clinical Course and Molecular Viral Shedding Among Asymptomatic and Symptomatic Patients With #SARS-CoV-2 Infection in a Community Treatment Center in the Republic of Korea
There is limited information about the clinical course and viral load in asymptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).. Epidemiologic, demographic, and laboratory data were collected and analyzed. Attending health care personnel carefully identified patients’ symptoms during isolation. The decision to release an individual from isolation was based on the results… Continue reading Clinical Course and Molecular Viral Shedding Among Asymptomatic and Symptomatic Patients With #SARS-CoV-2 Infection in a Community Treatment Center in the Republic of Korea
Mandated Bacillus Calmette-Guérin (#BCG) vaccination predicts flattened curves for the spread of #COVID-19
Bacillus Calmette-Guérin (BCG) vaccination may reduce the risk of a range of infectious diseases, and if so, it could protect against coronavirus disease 2019 (COVID-19). Here, we compared countries that mandated BCG vaccination until at least 2000 with countries that did not. To minimize any systematic effects of reporting biases, we analyzed the rate of… Continue reading Mandated Bacillus Calmette-Guérin (#BCG) vaccination predicts flattened curves for the spread of #COVID-19
Selective and cross-reactive #SARS-CoV-2 #T cell epitopes in unexposed humans
Many unknowns exist about human immune responses to the SARS-CoV-2 virus. SARS-CoV-2 reactive CD4+ T cells have been reported in unexposed individuals, suggesting pre-existing cross-reactive T cell memory in 20-50% of people. However, the source of those T cells has been speculative. Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019,… Continue reading Selective and cross-reactive #SARS-CoV-2 #T cell epitopes in unexposed humans
Google searches for #suicide and suicide risk factors in the early stages of the #COVID-19 pandemic
A novel coronavirus (SARS-CoV-2), which causes the COVID-19 respiratory illness, emerged in December of 2019 and has since spread globally. The dramatic lifestyle changes and stressors associated with this pandemic pose a threat to mental health and have the potential to exacerbate risk factors for suicide. We used autoregressive integrated moving average (ARIMA) models to… Continue reading Google searches for #suicide and suicide risk factors in the early stages of the #COVID-19 pandemic
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)
Coronavirus disease 2019 (COVID-19) continues to cause considerable morbidity and mortality worldwide. Case reports of hospitalized patients suggest that COVID-19 prominently affects the cardiovascular system, but the overall impact remains unknown. ..Of the 100 included patients, 53 (53%) were male, and the median (interquartile range [IQR]) age was 49 (45-53) years. The median (IQR) time… Continue reading Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)
#Cerebrovascular and Neurological Dysfunction under the Threat of #COVID-19: Is There a Comorbid Role for #Smoking and Vaping?
The recently discovered novel coronavirus, SARS-CoV-2 (COVID-19 virus), has brought the whole world to standstill with critical challenges, affecting both health and economic sectors worldwide. Although initially, this pandemic was associated with causing severe pulmonary and respiratory disorders, recent case studies reported the association of cerebrovascular-neurological dysfunction in COVID-19 patients, which is also life-threatening. Several… Continue reading #Cerebrovascular and Neurological Dysfunction under the Threat of #COVID-19: Is There a Comorbid Role for #Smoking and Vaping?
#Tocilizumab for treatment of mechanically ventilated patients with #COVID-19
Severe COVID-19 can manifest in rapid decompensation and respiratory failure with elevated inflammatory markers, consistent with cytokine release syndrome for which IL-6 blockade is approved treatment We assessed effectiveness and safety of IL-6 blockade with tocilizumab in a single-center cohort of patients with COVID-19 requiring mechanical ventilation. The primary endpoint was survival probability post-intubation; secondary… Continue reading #Tocilizumab for treatment of mechanically ventilated patients with #COVID-19
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