Natural history of acute #kidney disease in patients with #cirrhosis

In 2012, KDIGO group proposed new definitions for Acute Kidney Injury (AKI), Acute Kidney Disease (AKD) and Chronic Kidney Disease (CKD). According to the definition adapted by the International Club of Ascites (ICA), AKI has been extensively investigated in patients with cirrhosis. On the contrary, there are currently no data on the epidemiology and clinical… Continue reading Natural history of acute #kidney disease in patients with #cirrhosis

The change in #kidney function was associated with #carotid artery plaque in a community-based population: a cohort study

We performed the current study to evaluate the association between dynamic change in estimated glomerular filtration rate (eGFR) and the risk of carotid artery plaque (CAP) in a community-based population A total number of 37,093 Chinese adults (21,790 men and 15,303 women, aged 42.6±11.6 years) free of chronic kidney diseases were enrolled. The change in… Continue reading The change in #kidney function was associated with #carotid artery plaque in a community-based population: a cohort study

2020 Conversion of Urine Protein–Creatinine Ratio or Urine Dipstick Protein to Urine Albumin–Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis

Measuring albuminuria is the preferred method for defining and staging chronic kidney disease (CKD), but total urine protein or dipstick protein is often measured instead. This analysis presents equations for converting urine protein–creatinine ratio and dipstick protein to urine albumin–creatinine ratio, and finds that both may help in CKD screening, staging, and prognosis.. Equations to… Continue reading 2020 Conversion of Urine Protein–Creatinine Ratio or Urine Dipstick Protein to Urine Albumin–Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis

Use of sodium-glucose co-transporter 2 inhibitors and risk of serious #renal events: Scandinavian cohort study

..Cohort of 29 887 new users of SGLT2 inhibitors (follow-up time: dapagliflozin 66.1%; empagliflozin 32.6%; canagliflozin 1.3%) and 29 887 new users of an active comparator, dipeptidyl peptidase-4 inhibitors, matched 1:1 on the basis of a propensity score with 57 variables. Mean follow-up time was 1.7 (SD 1.0) years. ..The mean age of the study population was… Continue reading Use of sodium-glucose co-transporter 2 inhibitors and risk of serious #renal events: Scandinavian cohort study

Particulate #Matter and Albuminuria, Glomerular Filtration Rate, and Incident #CKD

Exposure to particulate matter (PM) <2.5 μm in aerodynamic diameter (PM2.5) has been linked to detrimental health effects. This study aimed to describe the relationship between long-term PM2.5 exposure and kidney disease, including eGFR, level of albuminuria, and incident CKD.. urinary albumin-creatinine ratio (UACR) ..There was no significant PM2.5-eGFR association at baseline. Each 1-μg/m3 higher… Continue reading Particulate #Matter and Albuminuria, Glomerular Filtration Rate, and Incident #CKD

Associations of #Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated #GFR

People receiving their first opioid prescription were propensity matched to people receiving NSAIDS (and, in sensitivity analysis, gabapentinoids) and the risk of death and hospitalization were compared, classifying opioid medication exposure as time-varying daily oral morphine milligram equivalents (MMEs) across time-varying eGFR. Prescriptions for 1–59 and ≥60 MMEs were associated with higher risk of death… Continue reading Associations of #Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated #GFR

Healthy Dietary Patterns and Incidence of CKD. A Meta-Analysis of Cohort Studies

Healthy dietary patterns typically encouraged higher intakes of vegetables, fruit, legumes, nuts, whole grains, fish and low-fat dairy, and lower intakes of red and processed meats, sodium, and sugar-sweetened beverages. A healthy dietary pattern was associated with a lower incidence of CKD (odds ratio [OR] 0.70 (95% confidence interval [95% CI], 0.60 to 0.82); I2=51%;… Continue reading Healthy Dietary Patterns and Incidence of CKD. A Meta-Analysis of Cohort Studies