Background: Atezolizumab plus bevacizumab (atezo+bev) is a standard-of-care 1L treatment for unresectable hepatocellular carcinoma (uHCC). Understanding its adoption and use, clinical outcomes, and subsequent therapies are needed.Methods: This retrospective cohort study included 550 patients with u #HCC in the US who initiated 1L atezo+bev between June 2020 and April 2023. Medical records were abstracted to… Continue reading Characteristics and outcomes of patients with #HCC treated with atezolizumab/bevacizumab, stratified by second line therapy
Electroacupuncture to point Baihui confers anxiolytic effects by promoting oxytocin release from PVN in Mice
Background: #Anxiety disorders-including generalized anxiety disorder, posttraumatic stress disorder, and social anxiety disorder-are highly prevalent psychiatric conditions that impose substantial clinical and social burdens. Preclinical and clinical studies have shown that #electroacupuncture (EA) can effectively alleviate anxiety-like behaviors; however, the specific neural circuits and molecular mechanisms underlying EA's therapeutic effects remain incompletely elucidated.Methods: We first… Continue reading Electroacupuncture to point Baihui confers anxiolytic effects by promoting oxytocin release from PVN in Mice
Laparoscopic peritoneal lavage versus surgical resection for the treatment of complicated perforated diverticulitis: A systematic review and meta-analysis
Introduction: Colonic diverticular disease ( #diverticulosis ) is a currently worldwide increasing gastrointestinal disorder with a particularly high prevalence in Western countries. The operative treatment of acute diverticulitis could be executed through open or laparoscopic techniques. A non-resectional procedure, namely laparoscopic peritoneal lavage (LPL) and drainage, has also been adopted as a less invasive treatment… Continue reading Laparoscopic peritoneal lavage versus surgical resection for the treatment of complicated perforated diverticulitis: A systematic review and meta-analysis
Effective prompt design for large language models in clinical #practice
Large language models ( #LLMs ) have emerged as transformative healthcare tools for clinical documentation, diagnostic reasoning, and medical education. However, effective utilization requires understanding prompt engineering principles—the strategic design of inputs to optimize performance while mitigating hallucination, bias, and outdated information.MethodsThis narrative review synthesizes evidence from a structured PubMed search through December 2025 using… Continue reading Effective prompt design for large language models in clinical #practice
Effect of #statin use on prognostic outcomes in #hepatocellular carcinoma following #liver surgery: a systematic review and meta-analysis
Hepatocellular carcinoma (HCC) recurrence remains a significant clinical challenge, even among patients who undergo surgical treatment. Although statins exhibit anticancer properties through several biologically plausible mechanisms, robust clinical evidence supporting their role in preventing HCC recurrence is still limited. This meta-analysis aimed to evaluate the impact of statin use on the prognostic outcomes of patients… Continue reading Effect of #statin use on prognostic outcomes in #hepatocellular carcinoma following #liver surgery: a systematic review and meta-analysis
#Rate control or #rhythm control strategies for stroke prevention in atrial #fibrillation: a systematic review and network meta-analysis
Atrial fibrillation (AF) is a major cause of stroke and thromboembolic events. We aimed to assess whether, in patients with AF, rate or rhythm control strategies reduce the risk for stroke or cardiovascular events.Methods and resultsRandomized controlled trials (RCTs) comparing rate control versus rhythm control strategies were systematically searched and included in a network meta-analysis… Continue reading #Rate control or #rhythm control strategies for stroke prevention in atrial #fibrillation: a systematic review and network meta-analysis
Over-the-Counter #Supplement Overuse: A Rare Potential Cause of #Arsenic Poisoning and #Bradycardia
A 71-year-old woman with no significant past medical history presented with progressive cognitive decline, fatigue, and weight loss over two years. Her symptoms included bradycardia, anxiety, depression, and mild dyspnea on exertion. The patient followed a strict diet fortified with smoothies and an extensive regimen of 26 dietary #supplements , consumed regularly over five years.… Continue reading Over-the-Counter #Supplement Overuse: A Rare Potential Cause of #Arsenic Poisoning and #Bradycardia
Understanding #Migration Intentions of Albanian #Physicians and Nurses
Introduction: Migration from Albanian healthcare professionals to Western countries has been widespread since Albania emerged from communism in 1991. The migration of Albanian physicians and nurses has significant impacts on the country's healthcare system.Objective: The manuscript addresses the migration intentions of Albanian healthcare professionals, including #physicians and nurses focusing on their inclination to emigrate to… Continue reading Understanding #Migration Intentions of Albanian #Physicians and Nurses
Liberal versus restrictive #transfusion strategies in patients with acute #brain injury: a systematic review and meta-analysis of randomized controlled trials
Anemia has been observed in up to 46% of individuals with acute brain injury. Blood transfusions are commonly performed to raise hemoglobin levels, so we aimed to compare the restrictive and liberal blood transfusion strategies in acute brain injury patients.MethodsA systematic search was conducted on Web of Science, Embase, Scopus, Cochrane, and Medline/PubMed up to… Continue reading Liberal versus restrictive #transfusion strategies in patients with acute #brain injury: a systematic review and meta-analysis of randomized controlled trials
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