Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies. We evaluated the associations between incident stroke and serum concentrations of nonesterified saturated, monounsaturated, polyunsaturated, and trans fatty acids. Methods and ResultsCHS (Cardiovascular Health Study) participants (N=2028) who were free of stroke at baseline (1996–1997)… Continue reading Serum Nonesterified #Fatty Acids and Incident #Stroke: The CHS
Downregulation of Erythrocyte miR-210 Induces #Endothelial Dysfunction in Type 2 #Diabetes
Red blood cells (RBCs) act as mediators of vascular injury in type 2 diabetes mellitus (T2DM). miR-210 plays a protective role in cardiovascular homeostasis and is decreased in whole blood of T2DM mice. We hypothesized that downregulation of RBC miR-210 induces endothelial dysfunction in T2DM. RBCs were co-incubated with arteries and endothelial cells ex vivo… Continue reading Downregulation of Erythrocyte miR-210 Induces #Endothelial Dysfunction in Type 2 #Diabetes
Experiences of Work-Family Conflict and #Mental Health Symptoms by Gender Among Physician Parents During the #COVID-19 Pandemic
The COVID-19 pandemic has placed increased strain on health care workers and disrupted childcare and schooling arrangements in unprecedented ways. As substantial gender inequalities existed in medicine before the pandemic, physician mothers may be at particular risk for adverse professional and psychological consequences. Objective To assess gender differences in work-family factors and mental health among… Continue reading Experiences of Work-Family Conflict and #Mental Health Symptoms by Gender Among Physician Parents During the #COVID-19 Pandemic
Charting host-microbe co-metabolism in #skin #aging and application to metagenomics data
During aging of human skin, a number of intrinsic and extrinsic factors cause the alteration of the skin’s structure, function and cutaneous physiology. Many studies have investigated the influence of the skin microbiome on these alterations, but the molecular mechanisms that dictate the interplay between these factors and the skin microbiome are still not fully… Continue reading Charting host-microbe co-metabolism in #skin #aging and application to metagenomics data
Serial Assessment of High-Sensitivity Cardiac #Troponin and the Effect of #Dapagliflozin in Patients with Heart #Failure with Reduced Ejection Fraction: An Analysis of the DAPA-HF Trial
Circulating high-sensitivity cardiac troponin T (hsTnT) predominantly reflects myocardial injury, and higher levels are associated with a higher risk of worsening heart failure (HF) and death in patients with HF with reduced ejection fraction (HFrEF). Less is known about the prognostic significance of changes in hsTnT over time, the effects of dapagliflozin on clinical outcomes… Continue reading Serial Assessment of High-Sensitivity Cardiac #Troponin and the Effect of #Dapagliflozin in Patients with Heart #Failure with Reduced Ejection Fraction: An Analysis of the DAPA-HF Trial
2021 #Dietary Guidance to Improve #Cardiovascular Health: A Scientific Statement From the American Heart Association
Poor diet quality is strongly associated with elevated risk of cardiovascular disease morbidity and mortality. This scientific statement emphasizes the importance of dietary patterns beyond individual foods or nutrients, underscores the critical role of nutrition early in life, presents elements of heart-healthy dietary patterns, and highlights structural challenges that impede adherence to heart-healthy dietary patterns.… Continue reading 2021 #Dietary Guidance to Improve #Cardiovascular Health: A Scientific Statement From the American Heart Association
A novel adverse effect of the BNT162b2 mRNA vaccine: First episode of acute #mania with #psychotic features
Dear Editor;A vaccine against SARS-CoV2, which is causing the global COVID-19 pandemic, was developed for the first-time using mRNA technology. Although the short- and long-term side-effects of the vaccine were unknown, emergency use authorization (EUA) was granted by the Food and Drug Administration (FDA) in December 2020(Parkash et al., 2021). Adverse effects such as tiredness,… Continue reading A novel adverse effect of the BNT162b2 mRNA vaccine: First episode of acute #mania with #psychotic features
Country roads, take me home… to my friends: How #intelligence, population density, and friendship affect modern #happiness
We propose the savanna theory of happiness, which suggests that it is not only the current consequences of a given situation but also its ancestral consequences that affect individuals’ life satisfaction and explains why such influences of ancestral consequences might interact with intelligence. We choose two varied factors that characterize basic differences between ancestral and… Continue reading Country roads, take me home… to my friends: How #intelligence, population density, and friendship affect modern #happiness
Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function
To investigate whether osteoarthritis (OA)–specific assessment values (i.e. Western Ontario and McMaster University Osteoarthritis Index [WOMAC]) and generic pain and function (visual analog scale [VAS], Hanover Functionality Status Questionnaire [FFbH]) measured before and 12 months after arthroplasty are associated with the risk of long-term mortality in a cohort of patients with advanced OA of the… Continue reading Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function
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