Category: Tech

Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets

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Antibody delivery to the CNS remains a huge hurdle for the clinical application of antibodies targeting a CNS antigen. The blood–brain barrier and blood–CSF barrier restrict access of therapeutic antibodies to their CNS targets in a major way. The very high amounts of therapeutic antibodies that are administered systemically in recent clinical trials to reach… Continue reading Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets

Association Between In-Person vs Telehealth Follow-up and Rates of Repeated Hospital Visits Among Patients Seen in the Emergency Department

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Importance  For patients discharged from the emergency department (ED), timely outpatient in-person follow-up is associated with improved mortality, but the effectiveness of telehealth as follow-up modality is unknown.Objective  To evaluate whether the rates of ED return visits and hospitalization differ between patients who obtain in-person vs telehealth encounters for post-ED follow-up care.Design, Setting, and Participants  This retrospective cohort… Continue reading Association Between In-Person vs Telehealth Follow-up and Rates of Repeated Hospital Visits Among Patients Seen in the Emergency Department

Ultrasonography in the prediction of gout flares: a 12-month prospective observational study

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ObjectivesTo evaluate whether US findings indicating MSU deposits and US-detected inflammation (i.e. power Doppler signal) predict gout flares over 12 months.MethodsGout patients on urate-lowering therapy for at least the preceding 6 months were enrolled consecutively in this 12-month prospective, observational, single-centre study. A nested case–control analysis was performed. Cases were participants with at least one flare in… Continue reading Ultrasonography in the prediction of gout flares: a 12-month prospective observational study

Bioresorbable Nanostructured Chemical Sensor for Monitoring of pH Level In Vivo

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Here, the authors report on the manufacturing and in vivo assessment of a bioresorbable nanostructured pH sensor. The sensor consists of a micrometer-thick porous silica membrane conformably coated layer-by-layer with a nanometer-thick multilayer stack of two polyelectrolytes labeled with a pH-insensitive fluorophore. The sensor fluorescence changes linearly with the pH value in the range 4… Continue reading Bioresorbable Nanostructured Chemical Sensor for Monitoring of pH Level In Vivo

Antibody–Invertase Fusion Protein Enables Quantitative Detection of SARS-CoV-2 Antibodies Using Widely Available Glucometers

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Rapid diagnostics that can accurately inform patients of disease risk and protection are critical to mitigating the spread of the current COVID-19 pandemic and future infectious disease outbreaks. To be effective, such diagnostics must rely on simple, cost-effective, and widely available equipment and should be compatible with existing telehealth infrastructure to facilitate data access and… Continue reading Antibody–Invertase Fusion Protein Enables Quantitative Detection of SARS-CoV-2 Antibodies Using Widely Available Glucometers

Smartphone use undermines enjoyment of face-to-face social interactions

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Using a field experiment and experience sampling, we found the first evidence that phone use may undermine the enjoyment people derive from real world social interactions. In Study 1, we recruited over 300 community members and students to share a meal at a restaurant with friends or family. Participants were randomly assigned to keep their… Continue reading Smartphone use undermines enjoyment of face-to-face social interactions

The illusion of evidence based medicine

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Evidence based medicine has been corrupted by corporate interests, failed regulation, and commercialisation of academia, argue these authors The advent of evidence based medicine was a paradigm shift intended to provide a solid scientific foundation for medicine. The validity of this new paradigm, however, depends on reliable data from clinical trials, most of which are… Continue reading The illusion of evidence based medicine

‘The Corpse Bride Diet’: How TikTok Inundates Teens With Eating-Disorder Videos

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The app’s algorithm can send users down rabbit holes of narrow interest, resulting in potentially dangerous content such as emaciated images, purging techniques, hazardous diets and body shamingBy Tawnell D. Hobbs, Rob Barry and Yoree KohDec. 17, 2021 10:45 am ET TikTok is flooding teen users with videos of rapid-weight-loss competitions and ways to purge… Continue reading ‘The Corpse Bride Diet’: How TikTok Inundates Teens With Eating-Disorder Videos

Digital Interventions for the Treatment of Depression:A Meta-Analytic Review

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The high global prevalence of depression, together with the recent acceleration of remote care owingto the COVID-19 pandemic, has prompted increased interest in the efficacy of digital interventions forthe treatment of depression. We provide a summary of the latest evidence base for digital interventionsin the treatment of depression based on the largest study sample to… Continue reading Digital Interventions for the Treatment of Depression:A Meta-Analytic Review