Yue, Luo, and colleagues discovered that adenosine signalling is the common underlying mechanism of rapid acting antidepressant therapies, unifying the effects of ketamine, ECT and acute intermittent hypoxia. They use genetically encoded sensors, along with extensive mechanistic dissection, to show that all three induce adenosine surges in mood-regulatory circuits via A1 and A2A receptor activation.… Continue reading #Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
Category: Psychiatry
#Acupuncture for Major #Depressive Disorder: Exploring the #Gut Microbiota as a Novel Therapeutic Pathway
This study investigates the efficacy of acupuncture at Baihui (GV20) and Zusanli (ST36) acupoints in alleviating depressive symptoms and elucidates the underlying mechanisms.MethodsSixty male C57BL/6J mice were subjected to an 8-week chronic unpredictable mild stress (CUMS) paradigm. Acupuncture was administered to two groups during the final 3 weeks: one under CUMS and the other without… Continue reading #Acupuncture for Major #Depressive Disorder: Exploring the #Gut Microbiota as a Novel Therapeutic Pathway
#Macroeconomic #income inequality, #brain structure and function, and #mental health
Income inequality, a structural property of societies characterized by the unequal distribution of resources, is associated with adverse mental health outcomes during adolescence, which is a sensitive period of neurodevelopment. While previous research has explored the impact of individual-level socioeconomic factors on brain structure and function, the neurobiological mechanisms linking structural inequality to mental health… Continue reading #Macroeconomic #income inequality, #brain structure and function, and #mental health
#Limbic gray matter increases in response to #cognitive-behavioral therapy in major #depressive disorder
Major depressive disorder (MDD) is related to volumetric decreases in (cortico-)limbic brain regions. In contrast to pharmacological and electroconvulsive therapy, little is known about the brain structural effects of psychotherapy and potential links to symptom improvements. In a naturalistic longitudinal study using structural magnetic resonance tomography, gray matter volume (GMV) and clinical measures were assessed… Continue reading #Limbic gray matter increases in response to #cognitive-behavioral therapy in major #depressive disorder
Exploring the link between daily job #burnout and violent #extremist attitudes: The role of negative affect and perceived organizational support
Objective: This study investigated whether daily experiences of job burnout are linked to violent extremist attitudes in the workplace, examining the mediating role of negative affect and the moderating influence of perceived organizational support. The theoretical framework integrates the existential model of burnout, significance quest theory, and general strain theory. Method: A 5-day daily-diary study… Continue reading Exploring the link between daily job #burnout and violent #extremist attitudes: The role of negative affect and perceived organizational support
Association Between #COVID-19 #Vaccination and #Neuropsychiatric Conditions
Introduction: This study explores the potential associations between COVID-19 vaccination and neuropsychiatric conditions. Methods: Data were collected from the CDC and FDA. The VAERS database was queried from January 1, 1990, to December 27, 2024, for adverse events (AEs) involving neuropsychiatric complications following COVID-19 vaccination. The timeframe included 420 months for all vaccines except COVID-19… Continue reading Association Between #COVID-19 #Vaccination and #Neuropsychiatric Conditions
#Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial
BackgroundNon-remission after psychological therapy for major depressive disorder is common, yet there are no established further-line treatments. In the UK National Health Service (NHS) Talking Therapies programme, about 50% of patients with depression who come to the end of the stepped care pathway do not show remission of symptoms. We aimed to investigate whether mindfulness-based… Continue reading #Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial
#Vagus nerve stimulation therapy for treatment-resistant #PTSD
BackgroundPosttraumatic stress disorder (PTSD) is common and debilitating, and many individuals do not respond to existing therapies. We developed a fundamentally novel neuromodulation-based therapy for treatment-resistant PTSD. This approach is premised on coupling prolonged exposure therapy, a first-line evidence-based cognitive behavioral therapy that directs changes within fear networks, with concurrent delivery of short bursts of… Continue reading #Vagus nerve stimulation therapy for treatment-resistant #PTSD
#Probiotics reduce negative #mood over time: the value of daily self-reports in detecting effects
The burgeoning field of the microbiome–gut–brain axis has inspired research into how the gut microbiome can affect human emotion. Probiotics offer ways to investigate microbial-based interventions but results have been mixed, with more evidence of beneficial effects in clinically depressed patients. Using a randomised, double-blind, placebo-controlled design in 88 healthy volunteers, we conduct a comprehensive… Continue reading #Probiotics reduce negative #mood over time: the value of daily self-reports in detecting effects
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