#Psychiatry risks losing its conceptual boundaries as the scope of its concern expands to include all forms of human unhappiness. This editorial argues that the discipline must distinguish clearly between illness and adversity, recognising that not all suffering is pathological. Drawing on historical and contemporary debates - from Jaspers' foundational dualism to Engel's biopsychosocial model,… Continue reading Psychiatry is not the science of unhappiness
Category: Psychiatry
Electroacupuncture to point Baihui confers anxiolytic effects by promoting oxytocin release from PVN in Mice
Background: #Anxiety disorders-including generalized anxiety disorder, posttraumatic stress disorder, and social anxiety disorder-are highly prevalent psychiatric conditions that impose substantial clinical and social burdens. Preclinical and clinical studies have shown that #electroacupuncture (EA) can effectively alleviate anxiety-like behaviors; however, the specific neural circuits and molecular mechanisms underlying EA's therapeutic effects remain incompletely elucidated.Methods: We first… Continue reading Electroacupuncture to point Baihui confers anxiolytic effects by promoting oxytocin release from PVN in Mice
#Wearable -derived heart rate variability and sleep monitoring as predictors of #mood episodes in bipolar disorder: a case report
Background: Bipolar disorder is a chronic psychiatric condition characterized by alternating episodes of mania and depression, and the prediction and management of mood episodes remain significant clinical challenges. Traditional assessments of mood states have largely relied on subjective methods, such as clinical interviews and self-report questionnaires, which present limitations in terms of early detection and… Continue reading #Wearable -derived heart rate variability and sleep monitoring as predictors of #mood episodes in bipolar disorder: a case report
The Overlooked Driver of #Hypertension: Mental #Stress at the Crossroad of Cardiology and Psychiatry
AbstractPurpose of ReviewMental stress has long been overlooked in the development of hypertension. We aim to provide new insights for clinicians in managing this condition.This review aims to summarize the epidemiological characteristics, complex mechanisms, diagnostic methods, as well as both non-pharmacological and pharmacological treatment strategies for mental stress-induced hypertension.Recent FindingsMany hypertensive patients continue to experience… Continue reading The Overlooked Driver of #Hypertension: Mental #Stress at the Crossroad of Cardiology and Psychiatry
#Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
Yue, Luo, and colleagues discovered that adenosine signalling is the common underlying mechanism of rapid acting antidepressant therapies, unifying the effects of ketamine, ECT and acute intermittent hypoxia. They use genetically encoded sensors, along with extensive mechanistic dissection, to show that all three induce adenosine surges in mood-regulatory circuits via A1 and A2A receptor activation.… Continue reading #Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
#Acupuncture for Major #Depressive Disorder: Exploring the #Gut Microbiota as a Novel Therapeutic Pathway
This study investigates the efficacy of acupuncture at Baihui (GV20) and Zusanli (ST36) acupoints in alleviating depressive symptoms and elucidates the underlying mechanisms.MethodsSixty male C57BL/6J mice were subjected to an 8-week chronic unpredictable mild stress (CUMS) paradigm. Acupuncture was administered to two groups during the final 3 weeks: one under CUMS and the other without… Continue reading #Acupuncture for Major #Depressive Disorder: Exploring the #Gut Microbiota as a Novel Therapeutic Pathway
#Macroeconomic #income inequality, #brain structure and function, and #mental health
Income inequality, a structural property of societies characterized by the unequal distribution of resources, is associated with adverse mental health outcomes during adolescence, which is a sensitive period of neurodevelopment. While previous research has explored the impact of individual-level socioeconomic factors on brain structure and function, the neurobiological mechanisms linking structural inequality to mental health… Continue reading #Macroeconomic #income inequality, #brain structure and function, and #mental health
#Limbic gray matter increases in response to #cognitive-behavioral therapy in major #depressive disorder
Major depressive disorder (MDD) is related to volumetric decreases in (cortico-)limbic brain regions. In contrast to pharmacological and electroconvulsive therapy, little is known about the brain structural effects of psychotherapy and potential links to symptom improvements. In a naturalistic longitudinal study using structural magnetic resonance tomography, gray matter volume (GMV) and clinical measures were assessed… Continue reading #Limbic gray matter increases in response to #cognitive-behavioral therapy in major #depressive disorder
Exploring the link between daily job #burnout and violent #extremist attitudes: The role of negative affect and perceived organizational support
Objective: This study investigated whether daily experiences of job burnout are linked to violent extremist attitudes in the workplace, examining the mediating role of negative affect and the moderating influence of perceived organizational support. The theoretical framework integrates the existential model of burnout, significance quest theory, and general strain theory. Method: A 5-day daily-diary study… Continue reading Exploring the link between daily job #burnout and violent #extremist attitudes: The role of negative affect and perceived organizational support
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