UHRF1 maintains DNA methylation by recruiting DNA methyltransferases to chromatin. In mouse, these dynamics are potently antagonized by a natural UHRF1 inhibitory protein STELLA, while the comparable effects of its human ortholog are insufficiently characterized, especially in cancer cells. Herein, we demonstrate that human STELLA (hSTELLA) is inadequate, while mouse STELLA (mSTELLA) is fully proficient… Continue reading Defining ortholog-specific UHRF1 inhibition by STELLA for #cancer therapy
Category: practice
The massed-spaced #learning effect in non-neural human #cells
The massed-spaced effect is a hallmark feature of memory formation. We now demonstrate this effect in two separate non-neural, immortalized cell lines stably expressing a short-lived luciferase reporter controlled by a CREB-dependent promoter. We emulate training using repeated pulses of forskolin and/or phorbol ester, and, as a proxy for memory, measure luciferase expression at various… Continue reading The massed-spaced #learning effect in non-neural human #cells
Distinct risk groups with different healthcare barriers and acute care use exist in the U.S. population with chronic #liver disease
BackgroundThe relationship between community-based healthcare barriers and risk of recurrent hospital-based care among persons with chronic liver disease (CLD) is understudied. We aimed to uncover distinct groups among adults in the United States with CLD based on healthcare barriers and risk-stratify recurrent acute care use by group.MethodsUsing National Health Interview Survey (2011 to 2017) data,… Continue reading Distinct risk groups with different healthcare barriers and acute care use exist in the U.S. population with chronic #liver disease
Effect of #chair placement on physicians’ #behavior and patients’ satisfaction: randomized deception trial
Objective To evaluate the effect of chair placement on length of time physicians sit during a bedside consultation and patients’ satisfaction.Design Single center, double blind, randomized controlled deception trial.Setting County hospital in Texas, USA.Participants 51 hospitalist physicians providing direct care services, and 125 observed encounters of patients who could answer four orientation questions correctly before study entry, April 2022… Continue reading Effect of #chair placement on physicians’ #behavior and patients’ satisfaction: randomized deception trial
Molecular dissection of cobra #venom highlights #heparinoids as an antidote for spitting cobra envenoming
Editor’s summarySnakebite is considered a neglected tropical disease by the World Health Organization, and although antibody-based antivenoms exist, they are species specific, are expensive, and require cold storage as well as intravenous administration in a health care setting. Here, Du and colleagues conducted a whole-genome CRISPR knockout screen to identify genes required for spitting cobra… Continue reading Molecular dissection of cobra #venom highlights #heparinoids as an antidote for spitting cobra envenoming
Industry Payments to Physicians Endorsing #Drugs and Devices on a #Social Media Platform
Physicians commonly receive financial payments from industry, totaling $2.46 billion in 2022. These payments can represent scientific collaboration but may involve marketing efforts without scientific benefits, raising concerns regarding their influence on clinical decision-making.. https://jamanetwork.com/journals/jama/article-abstract/2819356
‘Death by 1000 Cuts’: Medscape National #Physician #Burnout & #Suicide Report 2021
The Transformative Power of Gratitude: A Journey into Presence
In the tapestry of human existence, few threads weave a narrative as profound as the essence of gratitude. Robert Holden’s timeless wisdom encapsulated in the words, “The more grateful you are, the more present you become,” unveils a profound truth that beckons us to embark on a transformative journey into the depths of mindfulness and… Continue reading The Transformative Power of Gratitude: A Journey into Presence
Changes in #Hospital Adverse Events and Patient Outcomes Associated With #Private Equity Acquisition
The effects of private equity acquisitions of US hospitals on the clinical quality of inpatient care and patient outcomes remain largely unknown.Objective To examine changes in hospital-acquired adverse events and hospitalization outcomes associated with private equity acquisitions of US hospitals.Design, Setting, and Participants Data from 100% Medicare Part A claims for 662 095 hospitalizations at 51 private equity–acquired… Continue reading Changes in #Hospital Adverse Events and Patient Outcomes Associated With #Private Equity Acquisition
2 Medical News 