Purpose: NT-proBNP, a peptide biomarker synthesized and secreted by cardiomyocytes in response to cardiac load, has gained attention in recent years for its potential role in respiratory diseases. Chronic Obstructive Pulmonary Disease (COPD), a chronic and progressive inflammatory condition affecting the respiratory system, is frequently associated with comorbidities involving the cardiovascular system. Consequently, the aim of… Continue reading NT-proBNP in Different Patient Groups of COPD: A Systematic Review and Meta-Analysis
Category: Pneumology
Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial
The clinical value of using digital tools to assess adherence and lung function in uncontrolled asthma is not known. We aimed to compare treatment decisions guided by digitally acquired data on adherence, inhaler technique, and peak flow with existing methods.MethodsA 32-week prospective, multicentre, single-blinded, parallel, randomly controlled trial was done in ten severe asthma clinics… Continue reading Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial
Increased risk of osteoarthritis in patients with atopic disease
Objectives To determine the incidence of osteoarthrits (OA) in patients with atopic disease compared with matched non-exposed patients.Methods We conducted a retrospective cohort study with propensity score matching using claims data from Optum’s de-identified Clinformatics Data Mart (CDM) (January 2003 to June 2019) and electronic health record data from the Stanford Research Repository (STARR) (January 2010 to… Continue reading Increased risk of osteoarthritis in patients with atopic disease
Cannabis legalization and childhood asthma in the United States: An ecologic analysis
Cannabis use is increasing among adults with children in the home particularly in states with cannabis legalization for medical (MCL) and/or recreational use (RCL), relative to states where cannabis use remains illegal at the state level. Exposure to secondhand smoke is a key risk factor for asthma among children. The objective of the current study… Continue reading Cannabis legalization and childhood asthma in the United States: An ecologic analysis
Sputum Type 2 Markers Could Predict Remission in Severe Asthma Treated With Anti-IL-5
Biotherapies targeting IL-5 allow a tangible improvement of asthma. However, all patients do not respond the same way to these treatments. Even if high blood eosinophil counts seem to be associated with a reduction in exacerbations with treatment targeting IL-5, we lack biomarkers for the prediction of remission after these very expensive treatments.Research QuestionDoes the… Continue reading Sputum Type 2 Markers Could Predict Remission in Severe Asthma Treated With Anti-IL-5
Differential impact of low fat-free mass in people with COPD based on body mass index classifications: results from COSYCONET
BackgroundAlterations in body composition, including a low fat-free mass index (FFMI), are common in patients with chronic obstructive pulmonary disease (COPD) and occur regardless of body weight.Research questionIs the impact of low FFMI on exercise capacity, health-related quality of life (HRQL) and systemic inflammation different among COPD patients stratified in different body mass index classifications?Study… Continue reading Differential impact of low fat-free mass in people with COPD based on body mass index classifications: results from COSYCONET
Persistent Asthma Is Associated With Carotid Plaque in MESA
BackgroundAsthma and atherosclerotic cardiovascular disease share an underlying inflammatory pathophysiology. We hypothesized that persistent asthma is associated with carotid plaque burden, a strong predictor of atherosclerotic cardiovascular disease events.Methods and ResultsThe MESA (Multi‐Ethnic Study of Atherosclerosis) enrolled adults free of known atherosclerotic cardiovascular disease at baseline. Subtype of asthma was determined at examination 1. Persistent… Continue reading Persistent Asthma Is Associated With Carotid Plaque in MESA
Chest CT Findings in Marijuana Smokers
BackgroundGlobal consumption of marijuana is increasing, but there is a paucity of evidence concerning associated lung imaging findings.PurposeTo use chest CT to investigate the effects of marijuana smoking in the lung.Materials and MethodsThis retrospective case-control study evaluated results of chest CT examinations (from October 2005 to July 2020) in marijuana smokers, nonsmoker control patients, and… Continue reading Chest CT Findings in Marijuana Smokers
Association Between Aluminum Exposure From Vaccines Before Age 24 Months and Persistent Asthma at Age 24 to 59 Months
ObjectiveTo assess the association between cumulative aluminum exposure from vaccines before age 24 months and persistent asthma at age 24 to 59 months.MethodsA retrospective cohort study was conducted in the Vaccine Safety Datalink (VSD). Vaccination histories were used to calculate cumulative vaccine-associated aluminum in milligrams (mg). The persistent asthma definition required one inpatient or 2 outpatient asthma… Continue reading Association Between Aluminum Exposure From Vaccines Before Age 24 Months and Persistent Asthma at Age 24 to 59 Months
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