Background: Chronic non-specific low back pain (CNSLBP) is often associated with morphological changes in the lumbar multifidus muscle (LMF), such as reduced cross-sectional area (CSA) and increased fat infiltration, compromising spinal stability and function. Core stabilization exercises aim to enhance neuromuscular control by targeting deep trunk muscles. However, few randomized trials have investigated their effects… Continue reading Effect of core stabilization exercises on #lumbar multifidus morphology and functional outcomes in chronic non-specific low #back pain: a randomized controlled trial
Category: Pain
ReviewPractical guidance for navigating #buprenorphine discontinuation
Approximately 4.8 million people in the United States had opioid use disorder in 2024, with more than one hundred thousand experiencing an overdose death. Despite the established benefits of buprenorphine on morbidity and mortality, many patients may express an interest in discontinuing their medications for various reasons, including stigma surrounding addiction. There are limited studies… Continue reading ReviewPractical guidance for navigating #buprenorphine discontinuation
[Thermo- #electroacupuncture at #yaosanzhen for chronic #lumbar #muscle strain of cold dampness: a randomized controlled trial]
Objective: To compare the clinical efficacy between thermo-electroacupuncture at yaosanzhen and oral celecoxib in the treatment of chronic lumbar muscle strain with cold dampness.Methods: A total of 80 patients with chronic lumbar muscle strain of cold dampness were randomly divided into an observation group (40 cases, 1 case dropped out) and a control group (40… Continue reading [Thermo- #electroacupuncture at #yaosanzhen for chronic #lumbar #muscle strain of cold dampness: a randomized controlled trial]
The effect of commonly used non- #antibiotic medications on #antimicrobial resistance development in #Escherichia coli
Antimicrobial resistance (AMR) poses a global threat to public health. While antibiotic overuse is a primary driver, emerging evidence suggests that non-antibiotic medications (NAMs) may also contribute. This concern is particularly relevant in residential aged care facilities (RACFs), where both NAMs and antibiotics are frequently used. We investigated whether nine commonly used NAMs in RACFs,… Continue reading The effect of commonly used non- #antibiotic medications on #antimicrobial resistance development in #Escherichia coli
Risk of #dementia following #gabapentin prescription in chronic low back #pain patients
Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain.Methods We conducted a retrospective cohort study using the TriNetX national database of de-identified patient records from 2004 to 2024.… Continue reading Risk of #dementia following #gabapentin prescription in chronic low back #pain patients
“Being away from everything”: Exploring the importance of access to #nature for individuals living with chronic low #back #pain
Highlights• Accessing nature spaces is important in the self-management of chronic low back pain.• Accessibility is undermined by disability, environmental obstacles or hazards, or proximity.• This represents an unmet clinical need which could be explored through virtual reality therapy. AbstractChronic low back pain is a persistent and debilitating condition, and therapeutic outcomes in the long… Continue reading “Being away from everything”: Exploring the importance of access to #nature for individuals living with chronic low #back #pain
Common interventional procedures for chronic non-cancer #spine #pain: a systematic review and network meta-analysis of randomised trials
Objective To address the comparative effectiveness of common interventional procedures for chronic non-cancer (axial or radicular) spine pain.Design Systematic review and network meta-analysis (NMA) of randomised controlled trials (RCTs).Data sources Medline, Embase, CINAHL, CENTRAL, and Web of Science from inception to 24 January 2023.Study selection RCTs that enrolled patients with chronic non-cancer spine pain, randomised… Continue reading Common interventional procedures for chronic non-cancer #spine #pain: a systematic review and network meta-analysis of randomised trials
The endocannabinoid N-arachidonoyl dopamine is critical for #hyperalgesia induced by chronic #sleep disruption
Chronic pain is highly prevalent and is linked to a broad range of comorbidities, including sleep disorders. Epidemiological and clinical evidence suggests that chronic sleep disruption (CSD) leads to heightened pain sensitivity, referred to as CSD-induced hyperalgesia. However, the underlying mechanisms are unclear. The thalamic reticular nucleus (TRN) has unique integrative functions in sensory processing,… Continue reading The endocannabinoid N-arachidonoyl dopamine is critical for #hyperalgesia induced by chronic #sleep disruption
Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial
Opioid analgesics are commonly used for acute low back pain and neck pain, but supporting efficacy data are scarce. We aimed to investigate the efficacy and safety of a judicious short course of an opioid analgesic for acute low back pain and neck pain.MethodsOPAL was a triple-blinded, placebo-controlled randomised trial that recruited adults (aged ≥18… Continue reading Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial
2 Medical News 