Comparison of #fracture risk using different supplemental doses of #vitamin D, #calcium or their combination: a network meta-analysis of randomised controlled trials

Inconsistent findings in regard to association between different concentrations of vitamin D, calcium or their combination and the risk of fracture have been reported during the past decade in community-dwelling older people A total of 25 randomised controlled trials involving 43 510 participants fulfilled the inclusion criteria. There was no evidence that the risk of… Continue reading Comparison of #fracture risk using different supplemental doses of #vitamin D, #calcium or their combination: a network meta-analysis of randomised controlled trials

Effect of Intra-Articular #Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With #Osteoarthritis

..Among participants with symptomatic radiographic knee osteoarthritis, the intra-articular administration of 100 μg of sprifermin every 6 or 12 months vs placebo resulted in an improvement in total femorotibial joint cartilage thickness after 2 years that was statistically significant, but of uncertain clinical importance; there was no significant difference for 30 μg of sprifermin every… Continue reading Effect of Intra-Articular #Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With #Osteoarthritis