..Among our sample of adults who were 40‐69 years old at their midlife weight measure (n=13,669), 3,603 developed an arthritis condition. Compared with adults who maintained a normal‐normal BMI, the normal‐overweight, normal‐obese, overweight‐obese, and obese‐obese groups had significantly elevated risk of incident arthritis conditions. The obese‐overweight group had lower risk of incident arthritis conditions compared… Continue reading #Obesity Progression between Young Adulthood and Midlife and Incident #Arthritis: A Retrospective Cohort Study of US Adults
Category: Orthopedy
Comparison between clinical and ultrasound assessment of the ankle region in juvenile idiopathic #arthritis
To compare frequency of joint and tendon disease on ultrasound (US) and clinical examination (CE), and to investigate agreement between US and CE in ankles with clinically active juvenile idiopathic arthritis (JIA).. ..A total of 163 joints in 89 ankles had active synovitis on US. The tibiotalar joint (TTJ) was the most commonly affected joint… Continue reading Comparison between clinical and ultrasound assessment of the ankle region in juvenile idiopathic #arthritis
Association between #statin use and incidence or progression of #osteoarthritis: Meta-analysis of observational studies
..A total of 11 studies (679807 participants) were identified from the systematic literature search. No significant association between statin use and incidence (OR = 1.010; 95% CI: 0.968 to 1.055; P = 0.638) or progression (OR = 1.076; 95% CI: 0.824 to 1.405; P = 0.589) of OA was found in our meta-analysis. The meta-analysis… Continue reading Association between #statin use and incidence or progression of #osteoarthritis: Meta-analysis of observational studies
Physical Therapy versus Glucocorticoid Injection for #Osteoarthritis of the Knee
..We enrolled 156 patients with a mean age of 56 years; 78 patients were assigned to each group. Baseline characteristics, including severity of pain and level of disability, were similar in the two groups. The mean (±SD) baseline WOMAC scores were 108.8±47.1 in the glucocorticoid injection group and 107.1±42.4 in the physical therapy group. At… Continue reading Physical Therapy versus Glucocorticoid Injection for #Osteoarthritis of the Knee
Subcutaneous #tanezumab for #osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period
..Patients were randomised to tanezumab 2.5 mg or 5 mg subcutaneously or matching placebo every 8 weeks (three doses). ..From March 2016 to December 2017, 849 patients were randomised and evaluated (placebo n=282, tanezumab 2.5 mg n=283, tanezumab 5 mg n=284). At week 24, there was a statistically significant improvement from baseline for tanezumab 5 mg compared with placebo… Continue reading Subcutaneous #tanezumab for #osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period
Association of intermittent and constant #knee pain patterns with knee pain severity, radiographic knee #osteoarthritis duration and severity
..Intermittent and Constant OA Pain (ICOAP) scores were characterized as 1) no intermittent or constant pain; 2) intermittent pain only; 3) constant pain only; and 4) a combination of constant and intermittent pain. Knee pain severity was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale and the Visual Analog Scale… Continue reading Association of intermittent and constant #knee pain patterns with knee pain severity, radiographic knee #osteoarthritis duration and severity
Surgery versus Conservative Care for Persistent #Sciatica Lasting 4 to 12 Months
..Among the patients assigned to undergo surgery, the median time from randomization to surgery was 3.1 weeks; of the 64 patients in the nonsurgical group, 22 (34%) crossed over to undergo surgery at a median of 11 months after enrollment. At baseline, the mean score for leg-pain intensity was 7.7 in the surgical group and… Continue reading Surgery versus Conservative Care for Persistent #Sciatica Lasting 4 to 12 Months
Reasons why #osteoarthritis predicts mortality: path analysis within a Cox proportional hazards model
To identify potentially modifiable factors that mediate the association between symptomatic osteoarthritis (OA) and premature mortality.. ..OA was significantly associated with mortality (TE-adjusted HR 1.14; 95% CI 1.00 to 1.29). The indirect effects for walking frequency were 1.05 (95% CI 1.04 to 1.06), depression 1.02 (95% CI 1.02 to 1.03), anxiety 1.01 (95% CI 1.00 to… Continue reading Reasons why #osteoarthritis predicts mortality: path analysis within a Cox proportional hazards model
Acute #kidney injury after primary total hip #arthroplasty: a risk multiplier for complication, mortality, and healthcare utilization
To assess whether acute kidney injury (AKI) is associated with more complications and higher healthcare utilization in people undergoing primary total hip arthroplasty (THA).. ..Adjusted for age, gender, race, income, underlying diagnosis, medical comorbidity, and the insurance payer, AKI in people who underwent primary THA was associated with significantly higher OR (95% CI) of (1)… Continue reading Acute #kidney injury after primary total hip #arthroplasty: a risk multiplier for complication, mortality, and healthcare utilization
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