INTRODUCTIONOur population-based study assessed whether clinically apparent Helicobacter pylori infection (CAHPI) is associated with the risk of Alzheimer's disease (AD).METHODSWe assembled a population-based cohort of all dementia-free subjects in the United Kingdom's Clinical Practice Research Datalink (UK CPRD), aged ≥50 years (1988–2017). Using a nested case-control approach, we matched each newly developed case of AD with 40… Continue reading Clinically apparent #Helicobacter pylori infection and the risk of incident #Alzheimer’s disease: A population-based nested case-control study
Category: Neurology
Neurophysiological and behavioral synchronization in group-living and #sleeping mice
Social interactions profoundly influence animal development, physiology, and behavior. Yet, how sleep—a central behavioral and neurophysiological process—is modulated by social interactions is poorly understood. Here, we characterized sleep behavior and neurophysiology in freely moving and co-living mice under different social conditions. We utilized wireless neurophysiological devices to simultaneously record multiple individuals within a group for 24 h, alongside video acquisition. We… Continue reading Neurophysiological and behavioral synchronization in group-living and #sleeping mice
Cortical reactivations predict future sensory responses
Many theories of offline memory consolidation posit that the pattern of neurons activated during a salient sensory experience will be faithfully reactivated, thereby stabilizing the pattern1,2. However, sensory-evoked patterns are not stable but, instead, drift across repeated experiences3,4,5,6. Here, to investigate the relationship between reactivations and the drift of sensory representations, we imaged the calcium… Continue reading Cortical reactivations predict future sensory responses
NR-SAFE: a randomized, double-blind safety trial of high dose #nicotinamide riboside in #Parkinson’s disease
Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains unknown, and doses exceeding 2000 mg daily have not been tested in humans. To evaluate the safety of high-dose NR therapy, we conducted a single-center, randomized, placebo-controlled, double-blind,… Continue reading NR-SAFE: a randomized, double-blind safety trial of high dose #nicotinamide riboside in #Parkinson’s disease
Simultaneous Comparisons of 25 Acute #Migraine Medications Based on 10 Million Users’ Self-Reported Records From a Smartphone Application
Many acute treatment options exist for migraine. However, large-scale, head-to-head comparisons of treatment effectiveness from real-world patient experience reports are lacking.MethodsThis is a retrospective analysis of 10,842,795 migraine attack records extracted from an e-diary smartphone application between June 30, 2014, and July 2, 2020. We analyzed 25 acute medications among seven classes- acetaminophen, NSAIDs, triptans,… Continue reading Simultaneous Comparisons of 25 Acute #Migraine Medications Based on 10 Million Users’ Self-Reported Records From a Smartphone Application
Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red #wine #headaches
The consumption of red wine induces headaches in some subjects who can drink other alcoholic beverages without suffering. The cause for this effect has been attributed to a number of components, often the high level of phenolics in red wine, but a mechanism has been elusive. Some alcohol consumers exhibit flushing and experience headaches, and… Continue reading Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red #wine #headaches
Association between #sleep hours and changes in #cognitive function according to the morningness-eveningness type: A population-based study
The aim of this study was to investigate proper sleep hours to reduce the risk of cognitive decrease considering morningness-eveningness type.MethodsThe Korean Community Health Survey was used, which includes adults aged over 19 years old. These data were obtained from a cross-sectional study and assessed sleep hours using questionnaire of Pittsburgh Sleep Quality Index. Based on the wake-up time… Continue reading Association between #sleep hours and changes in #cognitive function according to the morningness-eveningness type: A population-based study
Polygenic predisposition, #sleep duration, and #depression: evidence from a prospective population-based cohort
Suboptimal sleep durations and depression frequently cooccur. Short-sleep and long-sleep are commonly thought of as symptoms of depression, but a growing literature suggests that they may be prodromal. While each represents a process of mutual influence, the directionality between them remains unclear. Using polygenic scores (PGS), we investigate the prospective direction involved in suboptimal sleep… Continue reading Polygenic predisposition, #sleep duration, and #depression: evidence from a prospective population-based cohort
The endocannabinoid N-arachidonoyl dopamine is critical for #hyperalgesia induced by chronic #sleep disruption
Chronic pain is highly prevalent and is linked to a broad range of comorbidities, including sleep disorders. Epidemiological and clinical evidence suggests that chronic sleep disruption (CSD) leads to heightened pain sensitivity, referred to as CSD-induced hyperalgesia. However, the underlying mechanisms are unclear. The thalamic reticular nucleus (TRN) has unique integrative functions in sensory processing,… Continue reading The endocannabinoid N-arachidonoyl dopamine is critical for #hyperalgesia induced by chronic #sleep disruption
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