Objective To explore the nuanced relationship between sleep patterns, chronotype, quality and the influence of health and lifestyle factors on cognitive performance.Design, setting, participants This cross-sectional analysis used ordinary least squares regression within the UK Biobank database, assessing 26 820 participants aged 53–86 years, categorised into two cohorts: Cohort 1 (10 067 participants, 56% female; completed all four… Continue reading #Sleep duration, chronotype, #health and lifestyle factors affect cognition: a UK Biobank cross-sectional study
Category: Neurology
Multikingdom and functional gut #microbiota markers for #autism spectrum disorder
Associations between the gut microbiome and autism spectrum disorder (ASD) have been investigated although most studies have focused on the bacterial component of the microbiome. Whether gut archaea, fungi and viruses, or function of the gut microbiome, is altered in ASD is unclear. Here we performed metagenomic sequencing on faecal samples from 1,627 children (aged… Continue reading Multikingdom and functional gut #microbiota markers for #autism spectrum disorder
#AI-based differential diagnosis of #dementia etiologies on multimodal data
Differential diagnosis of dementia remains a challenge in neurology due to symptom overlap across etiologies, yet it is crucial for formulating early, personalized management strategies. Here, we present an artificial intelligence (AI) model that harnesses a broad array of data, including demographics, individual and family medical history, medication use, neuropsychological assessments, functional evaluations and multimodal… Continue reading #AI-based differential diagnosis of #dementia etiologies on multimodal data
#Acupuncture and #Sleep Quality Among Patients With #Parkinson DiseaseA Randomized Clinical Trial
Importance Poor sleep quality greatly impairs quality of life and accelerates deterioration in patients with Parkinson disease (PD), but current remedies remain limited. Acupuncture, used as an adjunctive therapy with anti-Parkinson medications, has shown positive effects in patients with PD. However, high-quality clinical evidence to support the effectiveness of acupuncture for patients with PD and poor… Continue reading #Acupuncture and #Sleep Quality Among Patients With #Parkinson DiseaseA Randomized Clinical Trial
Recurrent Ischemic #Stroke in Patients With Atrial #Fibrillation While Receiving Oral Anticoagulants
Importance Patients with atrial fibrillation (AF) can have an ischemic stroke (IS) despite oral anticoagulant (OAC) treatment. Knowledge regarding the association between OAC discontinuation and the subsequent risk of recurrent IS in patients with AF is limited.Objectives To determine the risk of recurrent IS in patients with AF receiving OAC and to evaluate the association between OAC… Continue reading Recurrent Ischemic #Stroke in Patients With Atrial #Fibrillation While Receiving Oral Anticoagulants
Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
Background and ObjectivesTerazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key adenosine triphosphate (ATP)–producing enzyme in glycolysis. It is hypothesized that the increase in energy availability in the brain may slow or prevent neurodegeneration, potentially by reducing the accumulation of alpha-synuclein. Recent work has suggested a… Continue reading Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
Changes in prevalence and incidence of #dementia and risk factors for dementia: an analysis from cohort studies
BackgroundSome cohort studies have reported a decline in dementia prevalence and incidence over time, although these findings have not been consistent across studies. We reviewed evidence on changes in dementia prevalence and incidence over time using published population-based cohort studies that had used consistent methods with each wave and aimed to quantify associated changes in… Continue reading Changes in prevalence and incidence of #dementia and risk factors for dementia: an analysis from cohort studies
Association of #Terazosin, #Doxazosin, or #Alfuzosin Use and Risk of #Dementia With Lewy Bodies in Men
Background and ObjectivesTerazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key adenosine triphosphate (ATP)–producing enzyme in glycolysis. It is hypothesized that the increase in energy availability in the brain may slow or prevent neurodegeneration, potentially by reducing the accumulation of alpha-synuclein. Recent work has suggested a… Continue reading Association of #Terazosin, #Doxazosin, or #Alfuzosin Use and Risk of #Dementia With Lewy Bodies in Men
Premenopausal bilateral #oophorectomy and #brain white matter brain integrity in later-life
INTRODUCTIONPremenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity.METHODSFemale participants with regional diffusion tensor imaging (DTI) metrics of fractional anisotropy (FA) and mean diffusivity (MD) were included (22 with PBO < 40 years; 43 with PBO 40-45… Continue reading Premenopausal bilateral #oophorectomy and #brain white matter brain integrity in later-life
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