AbstractPhysical exercise may reduce dementia risk in aging, but varying reports on its effectiveness make it challenging to ascribe what level of exercise will have significant longer-term effects on important functions such as hippocampal-based learning and memory. This study compared the effect of three different 6-month exercise regimens on hippocampal-dependent cognition in healthy, elderly individuals.… Continue reading Long-Term Improvement in Hippocampal-Dependent #Learning Ability in Healthy, Aged Individuals Following High Intensity Interval #Training
Category: Neurology
Efficacy of #Atogepant in Chronic #Migraine With and Without Acute Medication Overuse in the Randomized, Double-Blind, Phase 3 PROGRESS Trial
AbstractBackground and ObjectivesAtogepant is an oral, calcitonin gene-related peptide receptor antagonist approved for the preventive treatment of migraine. We evaluated the efficacy of atogepant for the preventive treatment of chronic migraine (CM) in participants with and without acute medication overuse.MethodsThis subgroup analysis of the phase 3, 12-week, randomized, double-blind, placebo-controlled PROGRESS trial evaluated adults with… Continue reading Efficacy of #Atogepant in Chronic #Migraine With and Without Acute Medication Overuse in the Randomized, Double-Blind, Phase 3 PROGRESS Trial
Nasal tau #immunotherapy clears intracellular #tau pathology and improves cognitive functions in aged tauopathy mice
Editor’s summaryTau pathology is a common denominator for neurodegenerative diseases such as Alzheimer’s disease or frontotemporal dementia, but selectively targeting toxic tau remains a challenge. Here, Gaikwad et al. developed a conformation-specific antibody for tau and demonstrated selective targeting of toxic tau aggregates in patient-derived tissue and tau oligomers in vitro. Packed into lipophile micelles, the antibody… Continue reading Nasal tau #immunotherapy clears intracellular #tau pathology and improves cognitive functions in aged tauopathy mice
#Sleep duration, chronotype, #health and lifestyle factors affect cognition: a UK Biobank cross-sectional study
Objective To explore the nuanced relationship between sleep patterns, chronotype, quality and the influence of health and lifestyle factors on cognitive performance.Design, setting, participants This cross-sectional analysis used ordinary least squares regression within the UK Biobank database, assessing 26 820 participants aged 53–86 years, categorised into two cohorts: Cohort 1 (10 067 participants, 56% female; completed all four… Continue reading #Sleep duration, chronotype, #health and lifestyle factors affect cognition: a UK Biobank cross-sectional study
Multikingdom and functional gut #microbiota markers for #autism spectrum disorder
Associations between the gut microbiome and autism spectrum disorder (ASD) have been investigated although most studies have focused on the bacterial component of the microbiome. Whether gut archaea, fungi and viruses, or function of the gut microbiome, is altered in ASD is unclear. Here we performed metagenomic sequencing on faecal samples from 1,627 children (aged… Continue reading Multikingdom and functional gut #microbiota markers for #autism spectrum disorder
#AI-based differential diagnosis of #dementia etiologies on multimodal data
Differential diagnosis of dementia remains a challenge in neurology due to symptom overlap across etiologies, yet it is crucial for formulating early, personalized management strategies. Here, we present an artificial intelligence (AI) model that harnesses a broad array of data, including demographics, individual and family medical history, medication use, neuropsychological assessments, functional evaluations and multimodal… Continue reading #AI-based differential diagnosis of #dementia etiologies on multimodal data
#Acupuncture and #Sleep Quality Among Patients With #Parkinson DiseaseA Randomized Clinical Trial
Importance Poor sleep quality greatly impairs quality of life and accelerates deterioration in patients with Parkinson disease (PD), but current remedies remain limited. Acupuncture, used as an adjunctive therapy with anti-Parkinson medications, has shown positive effects in patients with PD. However, high-quality clinical evidence to support the effectiveness of acupuncture for patients with PD and poor… Continue reading #Acupuncture and #Sleep Quality Among Patients With #Parkinson DiseaseA Randomized Clinical Trial
Recurrent Ischemic #Stroke in Patients With Atrial #Fibrillation While Receiving Oral Anticoagulants
Importance Patients with atrial fibrillation (AF) can have an ischemic stroke (IS) despite oral anticoagulant (OAC) treatment. Knowledge regarding the association between OAC discontinuation and the subsequent risk of recurrent IS in patients with AF is limited.Objectives To determine the risk of recurrent IS in patients with AF receiving OAC and to evaluate the association between OAC… Continue reading Recurrent Ischemic #Stroke in Patients With Atrial #Fibrillation While Receiving Oral Anticoagulants
Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
Background and ObjectivesTerazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key adenosine triphosphate (ATP)–producing enzyme in glycolysis. It is hypothesized that the increase in energy availability in the brain may slow or prevent neurodegeneration, potentially by reducing the accumulation of alpha-synuclein. Recent work has suggested a… Continue reading Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
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