Antibiotic use is a risk factor for development of inflammatory bowel diseases (IBDs). IBDs are characterized by a damaged mucus layer, which does not separate the intestinal epithelium from the microbiota. Here, we hypothesized that antibiotics affect the integrity of the mucus barrier, which allows bacterial penetrance and predisposes to intestinal inflammation. We found that… Continue reading #Antibiotics damage the #colonic mucus barrier in a #microbiota-independent manner
Category: Infectivology
#Spike Protein Impairs #Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying #Cardiac Injury in COVID-19
Background: COVID-19 has a major impact on cardiovascular diseases and may lead to myocarditis or cardiac failure. The clove-like spike (S) protein of SARS-CoV-2 facilitates its transmission and pathogenesis. Cardiac mitochondria produce energy for key heart functions. We hypothesized that S1 would directly impair the functions of cardiomyocyte mitochondria, thus causing cardiac dysfunction.Methods: Through the Seahorse Mito… Continue reading #Spike Protein Impairs #Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying #Cardiac Injury in COVID-19
A case of biopsy-proven inflammatory dilated #cardiomyopathy following heterologous #mRNA -1273 third-dose immunization
Advances in mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have helped curb the coronavirus disease 2019 (COVID-19) pandemic and prevent disease onset and severity. Growing cases of vaccine-associated myocarditis (VAM) following SARS-CoV-2 immunization have been reported. Although COVID-19 VAM commonly occurs in young males after the second dose of vaccination, most cases are… Continue reading A case of biopsy-proven inflammatory dilated #cardiomyopathy following heterologous #mRNA -1273 third-dose immunization
#Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
•Early-life antibiotics increase the risk of allergy in adulthood•Antibiotics cause short-term disruption of the microbiome and systemic metabolome•Dysfunctional mitochondria in the airway epithelium lead to exaggerated inflammation•Indole-3-propionic acid counters the detrimental effects of early-life antibioticsSummaryAntibiotic use in early life disrupts microbial colonization and increases the risk of developing allergies and asthma. We report that mice… Continue reading #Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
A Systematic REVIEW of #Autopsy findings in deaths after #covid-19 vaccination
Highlights•We found that 73.9% of deaths were directly due to or significantly contributed to by COVID-19 vaccination.•Our data suggest a high likelihood of a causal link between COVID-19 vaccination and death.•These findings indicate the urgent need to elucidate the pathophysiologic mechanisms of death with the goal of risk stratification and avoidance of death for the… Continue reading A Systematic REVIEW of #Autopsy findings in deaths after #covid-19 vaccination
#Bartonella species bacteremia in association with adult #psychosis
Introduction: The potential role of pathogens, particularly vector-transmitted infectious agents, as a cause of psychosis has not been intensively investigated. We have reported a potential link between Bartonella spp. bacteremia and neuropsychiatric symptoms, including pediatric acute onset neuropsychiatric syndrome and schizophrenia. The purpose of this study was to further assess whether Bartonella spp. exposure or infection are associated with psychosis.Methods: In… Continue reading #Bartonella species bacteremia in association with adult #psychosis
Wearing face #masks did not reduce risk of #COVID infection after first Omicron wave, research shows
After the first Omicron wave, research shows that many of the risks of Covid infection changed Before February 2022, always wearing face masks and being retired were associated with reduced risk, but not after Overseas travel was not associated with increased risk prior to February 2022, but then became a significant risk Peer reviewed – meta-regression- humans New… Continue reading Wearing face #masks did not reduce risk of #COVID infection after first Omicron wave, research shows
#Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower #Respiratory Tract Infection
BackgroundAntibiotic use remains common for the treatment of lower respiratory tract infections. The objective of this study was to evaluate the impact of antibiotic use on the duration and severity of acute lower respiratory tract infection (LRTI).ParticipantsAdult patients presenting to US primary or urgent care sites with a chief complaint of cough and symptoms consistent… Continue reading #Antibiotics Not Associated with Shorter Duration or Reduced Severity of Acute Lower #Respiratory Tract Infection
#Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of #COVID-19
Persistent symptoms following SARS-CoV-2 infection are increasingly reported, although the drivers of post-acute sequelae (PASC) of COVID-19 are unclear. Here we assessed 214 individuals infected with SARS-CoV-2, with varying disease severity, for one year from COVID-19 symptom onset to determine the early correlates of PASC. A multivariate signature detected beyond two weeks of disease, encompassing… Continue reading #Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of #COVID-19
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