Highlights•SARS-CoV-2 activity is difficult to assess with conventional PCR assays.•Subgenomic RNA (sgRNA) may be a better proxy for infectivity.•Over 10% of COVID-19 patients were sgRNA positive beyond a 10-day period.•Long-duration sgRNA-positive patients were clinically unremarkable.•Vulnerable settings may require additional measures to minimize transmission.Abstract ObjectivesThis study aimed to evaluate the associations between COVID-19 severity and active… Continue reading Persistence of clinically relevant levels of SARS-CoV2 envelope gene subgenomic RNAs in non-immunocompromised individuals
Category: Infectivology
Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development
Vaccines have been developed at “warp speed” to combat the COVID-19 pandemic caused by the SARS-CoV-2 coronavirus. Although they are considered the best approach for preventing mortality, when assessing the safety of these vaccines, pregnant women have not been included in clinical trials. Thus, vaccine safety for this demographic, as well as for the developing… Continue reading Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development
COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status andPrevious COVID-19 Diagnosis — California and New York, May–November 2021
During the study period, COVID-19 incidence inboth states was highest among unvaccinated persons without aprevious COVID-19 diagnosis compared with that among theother three groups. During the week beginning May 30, 2021,compared with COVID-19 case rates among unvaccinated persons without a previous COVID-19 diagnosis, COVID-19case rates were 19.9-fold (California) and 18.4-fold (New York)lower among vaccinated persons… Continue reading COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status andPrevious COVID-19 Diagnosis — California and New York, May–November 2021
Expected Viscosity After COVID-19 Vaccination, Hyperviscosity and Previous COVID-19
COVID-19 vaccine is the hope for containment of disease outbreak. The post vaccination adverse effect is an important consideration. The clot after vaccination is an emerging important clinical problem in some vaccine recipients.1 The cause of post vaccination blood clot is not known. It is proposed that the problem might be due to immunopathological process.2… Continue reading Expected Viscosity After COVID-19 Vaccination, Hyperviscosity and Previous COVID-19
First time detection of the vaccine spike protein in a person who died after vaccination against Covid-19.
The suspicion that the spike protein formed in the body as a result of the "vaccination" against Covid-19 could be responsible for the pathologically observed inflammations and lesions of vessels has now been confirmed immunohistologically for the first time. The pathologists Prof. Dr. Arne Burkhardt and Prof. Dr. Walter Lang and their team have succeeded… Continue reading First time detection of the vaccine spike protein in a person who died after vaccination against Covid-19.
Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching
ORIGINAL ARTICLE PEER-REVIEWED Background: Ivermectin has demonstrated different mechanisms of action that potentially protect from both coronavirus disease 2019 (COVID-19) infection and COVID-19-related comorbidities. Based on the studies suggesting efficacy in prophylaxis combined with the known safety profile of ivermectin, a citywide prevention program using ivermectin for COVID-19 was implemented in Itajaí, a southern city… Continue reading Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching
Paracetamol in the home treatment of early COVID-19 symptoms: A possible foe rather than a friend for elderly patients?
On October 2020, Sestili and Fimognari reported that acetaminophen (N-aetyl-para-aminophenol), commonly known as paracetamol, induces or worsens glutathione (GSH) consumption in elderly patients affected by early or mild coronavirus disease 2019 (COVID-19), thus greatly enhancing the risk of COVID-19 exacerbation in these patients.1 By early COVID-19, we mean the typical or commonly acknowledged symptomatology associated… Continue reading Paracetamol in the home treatment of early COVID-19 symptoms: A possible foe rather than a friend for elderly patients?
Vitamin D deficiency is associated with higher risks for SARS-CoV-2 infection and COVID-19 severity: a retrospective case–control study
Robust evidence of whether vitamin D deficiency is associated with COVID-19 infection and its severity is still lacking. The aim of the study was to evaluate the association between vitamin D levels and the risks of SARS-CoV-2 infection and severe disease in those infected. A retrospective study was carried out among members of Clalit Health… Continue reading Vitamin D deficiency is associated with higher risks for SARS-CoV-2 infection and COVID-19 severity: a retrospective case–control study
COVID-19 trends and severity among symptomatic children aged 0-17 years in ten EU countries, 3 August 2020 – 3 October 2021
To guide evidence-based prevention of COVID-19 in children, we estimated risks of severe outcomes in 820,404 symptomatic paediatric cases reported by 10 EU Member States between August 2020 and October 2021. Case and hospitalisation rates rose as overall transmission increased but severe outcomes were rare: 9,611 (1.2%) were hospitalised, 640 (0.08%) required intensive care and… Continue reading COVID-19 trends and severity among symptomatic children aged 0-17 years in ten EU countries, 3 August 2020 – 3 October 2021
2 Medical News 