AbstractBackground: The Global COVID Vaccine Safety (GCoVS) Project, established in 2021 under the multinational Global Vaccine Data Network™ (GVDN®), facilitates comprehensive assessment of vaccine safety. This study aimed to evaluate the risk of adverse events of special interest (AESI) following COVID-19 vaccination from 10 sites across eight countries.Methods: Using a common protocol, this observational cohort… Continue reading COVID-19 #vaccines and #adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals
Category: Infectivology
Healthy #sleep patterns and risk of hospitalization for #infection: a large community-based cohort study
Sleep behaviours are potentially modifiable risk factors for infectious disease. However, little is known about the combined effects of multiple sleep factors on the risk of infections. We investigated the prospective associations of combined healthy sleep patterns with the risk of hospitalization for infection in 397,523 participants (mean (SD) age: 56.3 (8.1) years) from the… Continue reading Healthy #sleep patterns and risk of hospitalization for #infection: a large community-based cohort study
Intestinal #Microbiota Contributes to the Development of #Cardiovascular Inflammation and Vasculitis in Mice
Alterations in the intestinal microbiota contribute to the pathogenesis of various cardiovascular disorders, but how they affect the development of Kawasaki disease (KD) an acute pediatric vasculitis, remains unclear.METHODS:We used the Lactobacillus casei cell wall extract (LCWE) murine model of KD vasculitis to assess the contribution of the intestinal microbiota to the development of vascular… Continue reading Intestinal #Microbiota Contributes to the Development of #Cardiovascular Inflammation and Vasculitis in Mice
#Probiotics and #Fever Duration in Children With Upper Respiratory Tract Infections
Importance Upper respiratory tract infections (URTIs) are prevalent in children, prompting frequent health care consultations, especially among those with fever. Probiotics show potential as an adjuvant treatment for URTIs, but evidence in children is limited.Objective To evaluate the efficacy of a probiotic mixture containing Bifidobacterium breve M-16V, Bifidobacterium lactis HN019, and Lactobacillus rhamnosus HN001 in… Continue reading #Probiotics and #Fever Duration in Children With Upper Respiratory Tract Infections
The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Introduction: Vaccine-related myocarditis is recognized as a rare but important complication, especially after mass-scale mRNA COVID-19 vaccination. Knowledge regarding how to minimize the risk is limited. As NK cells can mediate acute myocarditis after mRNA COVID-19 vaccination and vitamin D may inhibit NK cells via cytokine modulation, we hypothesize that the myocarditis side effect is… Continue reading The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Development of a rapid antigen-based lateral flow assay for tick-borne spotted fever #rickettsioses
Tick-borne spotted fever rickettsioses (SFRs) continue to cause severe illness and death in otherwise-healthy individuals due to lack of a timely and reliable diagnostic laboratory test. We recently identified a diagnostic biomarker for SFRs, the putative N-acetylmuramoyl-l-alanine amidase RC0497. Here, we developed a prototype laboratory test that targets RC0497 for diagnosis of SFRs. The concentrations… Continue reading Development of a rapid antigen-based lateral flow assay for tick-borne spotted fever #rickettsioses
The influence of mechanical #ventilation and portable air cleaners upon aerosol spread in a hospital outpatients clinic
The SARS-CoV-2 global pandemic has highlighted the risk of nosocomial infections of airborne viruses to patient populations around the world. Increased use of mechanical ventilation and portable air cleaners (PACs) have been suggested as methods to mitigate this risk, but the introduction of new air flows to indoor areas can have complex and potentially unforeseen… Continue reading The influence of mechanical #ventilation and portable air cleaners upon aerosol spread in a hospital outpatients clinic
The physicochemical properties of #lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation
Lipopolysaccharide (LPS) is the primary pathogenic factor in Gram-negative sepsis. While the presence of LPS in the bloodstream during infection is associated with disseminated intravascular coagulation, the mechanistic link between LPS and blood coagulation activation remains ill-defined. The contact pathway of coagulation—a series of biochemical reactions that initiates blood clotting when plasma factors XII (FXII)… Continue reading The physicochemical properties of #lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation
The Immunologic Downsides Associated with the Powerful Translation of Current #COVID-19 Vaccine #mRNA Can Be Overcome by Mucosal Vaccines
The action of mRNA-based vaccines requires the expression of the antigen in cells targeted by lipid nanoparticle–mRNA complexes. When the vaccine antigen is not fully retained by the producer cells, its local and systemic diffusion can have consequences depending on both the levels of antigen expression and its biological activity. A peculiarity of mRNA-based COVID-19… Continue reading The Immunologic Downsides Associated with the Powerful Translation of Current #COVID-19 Vaccine #mRNA Can Be Overcome by Mucosal Vaccines
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