Cardiovascular adverse conditions are caused by coronavirus disease 2019 (COVID-19) infections and reported as side-effects of the COVID-19 vaccines. Enriching current vaccine safety surveillance systems with additional data sources may improve the understanding of COVID-19 vaccine safety. Using a unique dataset from Israel National Emergency Medical Services (EMS) from 2019 to 2021, the study aims… Continue reading Increased emergency cardiovascular events among under-40 population in Israel during vaccine rollout and third COVID-19 wave
Category: Infectivology
Rates of COVID-19 Among Unvaccinated Adults With Prior COVID-19
Risk of SARS-CoV-2 reinfection among unvaccinated people with prior COVID-19 is a subject of debate.1,2 We performed a survival analysis in a large US population to assess the degree and duration of protection associated with natural immunity in unvaccinated individuals MethodsThis cohort study used data from patients tested for SARS-CoV-2 at 1300 sites of care… Continue reading Rates of COVID-19 Among Unvaccinated Adults With Prior COVID-19
SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis
Background & AimsAutoimmune hepatitis episodes have been described following SARS-CoV-2 infection and vaccination but their pathophysiology remains unclear. Here, we report the case of a 52-year-old male, presenting with bimodal episodes of acute hepatitis, each occurring 2-3 weeks after BNT162b2 mRNA vaccination and sought to identify the underlying immune correlates. The patient received first oral… Continue reading SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis
SARS-CoV-2 Naturally Acquired Immunity vs. Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: a Retrospective Cohort Study
Background: Waning of protection against infection with SARS-CoV-2 conferred by 2 doses of the BNT162b2 vaccine begins shortly after inoculation and becomes substantial within four months. With that, the impact of prior infection on incident SARS-CoV-2 reinfection is unclear. Therefore, we examined the long-term protection of naturally acquired immunity (protection conferred by previous infection) compared… Continue reading SARS-CoV-2 Naturally Acquired Immunity vs. Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: a Retrospective Cohort Study
Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed
... DiscussionThis case illustrates immune-mediated hepatitis secondary to the Moderna vaccine, which on inadvertent re-exposure led to worsening liver injury with deranged synthetic function. This occurred in a well man with no other medical problems. The onset of jaundice associated with the mRNA vaccine was unusually rapid. This was also illustrated in the other cases… Continue reading Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed
COVID-19 Early Treatment with Non-Steroidal AntiInflammatory Drugs Reduces Hospitalizations andSymptom Duration
BackgroundAt the beginning of the SARS-CoV-2 pandemic we stated that,given the new virus and the little-known disease it caused, in theabsence of Evidence-Based Medicine indications, patients shouldhave been treated with drugs already available, useful to counteractthe pathophysiology of the COVID-19 [1]. Recent literature hasconfirmed that this could be a successful approach, demonstratingthat an early treatment… Continue reading COVID-19 Early Treatment with Non-Steroidal AntiInflammatory Drugs Reduces Hospitalizations andSymptom Duration
Auto-immune hepatitis following COVID vaccination
Unprecedented loss of life due to the COVID pandemic has necessitated the development of several vaccines in record time. Most of these vaccines have received approval without being extensively whetted for their adverse effect and efficacy profiles. Most adverse effects have been mild, nonetheless, more serious thromboembolic events have also been reported. Autoimmune hepatitis (AIH)… Continue reading Auto-immune hepatitis following COVID vaccination
Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial
Background. Associations between vitamin D (VD) deficiency and the risk of SARS-CoV-2 infection have been documented in cross-sectional population studies. Intervention studies in patients with moderate to severe COVID-19 have failed to consistently document a beneficial effect. Objective. To determine the efficacy and safety of VD-supplementation in the prevention of SARS-CoV-2 infection in highly exposed… Continue reading Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial
Psychological Distress Before and During the COVID-19 Pandemic Among Adults in the United Kingdom Based on Coordinated Analyses of 11 Longitudinal Studies
How population mental health has evolved across the COVID-19 pandemic under varied lockdown measures is poorly understood, and the consequences for health inequalities are unclear. Objective To investigate changes in mental health and sociodemographic inequalities from before and across the first year of the COVID-19 pandemic in 11 longitudinal studies. Design, Setting, and Participants This… Continue reading Psychological Distress Before and During the COVID-19 Pandemic Among Adults in the United Kingdom Based on Coordinated Analyses of 11 Longitudinal Studies
2 Medical News 