Early discontinuation of dual antiplatelet therapy (DAPT) within 3 months after implantation of drug-eluting stents may reduce bleeding risk without increasing ischaemic events. This study aimed to assess whether 3-month DAPT is as safe as the conventional 12-month regimen in patients treated with Firehawk stents, which have demonstrated 99.9% reendothelialisation at 3 months by optical… Continue reading Three vs 12-month #DAPT after implantation of biodegradable-polymer sirolimus-eluting coronary #stent : a randomised clinical trial
Category: Hematology
Clinical outcomes of #orthopaedic surgery patients with inferior vena #cava filter prophylaxis
AbstractPurpose: Orthopaedic surgery patients are at an elevated risk of venous thromboembolic events thus necessitating effective prophylaxis strategies.Methods: This IRB-approved, single-center retrospective study evaluated patients who underwent orthopaedic surgery and were protected with Inferior Vena Cava (IVC) filters from January 2007 to December 2021. Study outcomes include incidence of venous thromboembolism (VTE) in the form… Continue reading Clinical outcomes of #orthopaedic surgery patients with inferior vena #cava filter prophylaxis
#Erythrocytosis and #thromboembolic risks associated with #SGLT2 inhibitors in type 2 diabetes
This study aimed to determine if sodium-glucose co-transporter-2 inhibitors (SGLT2i) use in diabetic patients leads to erythrocytosis and increases the incidence of arterial and venous thrombosis events. This is a retrospective cohort study using records from over 50 U.S. healthcare organizations. Adults with type 2 diabetes who received SGLT2i therapy were compared to those on… Continue reading #Erythrocytosis and #thromboembolic risks associated with #SGLT2 inhibitors in type 2 diabetes
#Artificial #intelligence in #myeloid malignancies: Clinical applications of machine learning in myelodysplastic syndromes and acute myeloid #Leukemia
This review summarizes applications of machine learning (ML) in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), spanning diagnosis, prognostication, treatment prediction, and research tools. In diagnostics, deep learning applied to bone marrow smears, peripheral blood films, and flow cytometry has shown high sensitivity and specificity, outperforming conventional methods. ML-driven unsupervised clustering and consensus classification… Continue reading #Artificial #intelligence in #myeloid malignancies: Clinical applications of machine learning in myelodysplastic syndromes and acute myeloid #Leukemia
#Tattoos as a risk factor for malignant #lymphoma: a population-based case–control study
BackgroundThe popularity of tattoos has increased dramatically over the last few decades. Tattoo ink often contains carcinogenic chemicals, e.g., primary aromatic amines, polycyclic aromatic hydrocarbons, and metals. The tattooing process invokes an immunologic response that causes translocation of tattoo ink from the injection site. Deposition of tattoo pigment in lymph nodes has been confirmed but the long-term… Continue reading #Tattoos as a risk factor for malignant #lymphoma: a population-based case–control study
#Nicotinamide enhances natural #killer cell function and yields remissions in patients with non-Hodgkin #lymphoma
Administration of haploidentical donor natural killer (NK) cells, rituximab, and IL-2 to patients with non-Hodgkin lymphoma (NHL) has been shown to be safe, but the objective response rate was low, suggesting that further strategies to improve NK cell engraftment and function are needed. Here, Cichocki and colleagues showed that supplementation with nicotinamide during ex vivo… Continue reading #Nicotinamide enhances natural #killer cell function and yields remissions in patients with non-Hodgkin #lymphoma
Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design
Current treatments to prevent thrombosis, namely anticoagulants and platelets antagonists, remain complicated by the persistent risk of bleeding. Improved therapeutic strategies that diminish this risk would have a huge clinical impact. Antithrombotic agents that neutralize and inhibit polyphosphate (polyP) can be a powerful approach towards such a goal. Here, we report a design concept towards… Continue reading Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design
Prevalence of parvovirus B19 viraemia among German blood donations and the relationship to ABO and Rhesus blood group antigens
AbstractAsymptomatic blood donors can transmit human parvovirus B19 (B19V). We assessed the B19V prevalence amongst a large cohort of blood donations collected in Germany during 2015-2018. In total, 167,123 donations were screened for B19V DNA with 22 cases of viraemia identified (0.013% positive). Infections peaked at a four-year interval and the highest number of cases… Continue reading Prevalence of parvovirus B19 viraemia among German blood donations and the relationship to ABO and Rhesus blood group antigens
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