Question Is there an association between empagliflozin and the risk of nonproliferative diabetic retinopathy (NPDR) and diabetic retinopathy (DR) progression in patients with type 2 diabetes (T2D)?Findings In this cohort study, there was no association between empagliflozin and incident NPDR in patients with T2D who had no DR history; however, empagliflozin was associated with a… Continue reading #Empagliflozin and the Risk of #Retinopathy in Patients With Type 2 Diabetes
Category: Endocrinology
#Chocolate intake and risk of type 2 #diabetes: prospective cohort studies
Objective To prospectively investigate the associations between dark, milk, and total chocolate consumption and risk of type 2 diabetes (T2D) in three US cohorts.Design Prospective cohort studies.Setting Nurses’ Health Study (NHS; 1986-2018), Nurses’ Health Study II (NHSII; 1991-2021), and Health Professionals Follow-Up Study (HPFS; 1986-2020).Participants At study baseline for total chocolate analyses (1986 for NHS… Continue reading #Chocolate intake and risk of type 2 #diabetes: prospective cohort studies
Day-to-day associations between #testosterone, #sexual desire and #courtship efforts in young men
Testosterone plays important roles in reproductive behaviour in many species. Despite a common belief that testosterone regulates fluctuations in human sexual desire, there is little direct evidence that relates within-person changes in natural testosterone production to within-person changes in sexual desire. Here, we measured daily salivary testosterone concentrations from 41 adult men for one month,… Continue reading Day-to-day associations between #testosterone, #sexual desire and #courtship efforts in young men
#LEVOTHYROXINE USE AND #BONE LOSS IN #EUTHYROID #OLDER ADULTS: A LONGITUDINAL ANALYSIS FROM BALTIMORE LONGITUDINAL STUDY OF AGING | S3B-SPMS-1
Purpose: Levothyroxine (LT4) is the second most commonly prescribed medication in older adults. Frank hyperthyroidism accelerates bone turnover and even subclinical hyperthyroid has been associated with increased fracture risk. Data indicates that a significant proportion of thyroid hormone prescriptions may be given to older adults without hypothyroidism raising concerns about subsequent relative excess of thyroid… Continue reading #LEVOTHYROXINE USE AND #BONE LOSS IN #EUTHYROID #OLDER ADULTS: A LONGITUDINAL ANALYSIS FROM BALTIMORE LONGITUDINAL STUDY OF AGING | S3B-SPMS-1
Once-Weekly #Semaglutide in Persons with #Obesity and #Knee Osteoarthritis
BackgroundWeight reduction has been shown to alleviate symptoms of osteoarthritis of the knee, including pain. The effect of glucagon-like peptide-1 receptor agonists on outcomes in knee osteoarthritis among persons with obesity has not been well studied.MethodsWe conducted a 68-week, double-blind, randomized, placebo-controlled trial at 61 sites in 11 countries. Participants with obesity (a body-mass index… Continue reading Once-Weekly #Semaglutide in Persons with #Obesity and #Knee Osteoarthritis
Associations of #semaglutide with first-time diagnosis of #Alzheimer’s disease in patients with type 2 diabetes: Target trial emulation using nationwide real-world data in the US
INTRODUCTIONEmerging preclinical evidence suggests that semaglutide, a glucagon-like peptide receptor agonist (GLP-1RA) for type 2 diabetes mellitus (T2DM) and obesity, protects against neurodegeneration and neuroinflammation. However, real-world evidence for its ability to protect against Alzheimer's disease (AD) is lacking.METHODSWe conducted emulation target trials based on a nationwide database of electronic health records (EHRs) of 116… Continue reading Associations of #semaglutide with first-time diagnosis of #Alzheimer’s disease in patients with type 2 diabetes: Target trial emulation using nationwide real-world data in the US
A single bout of physical #exercise improves 1-hour post-load plasma #glucose in healthy young adults
PurposePhysical exercise is a key component in the treatment of type 2 diabetes and plays an important role in maintaining a healthy glucose metabolism even in healthy subjects. To date, no studies have investigated the effect of a single bout of aerobic physical exercise on glucose metabolism in young, moderately active, healthy adults.MethodsWe performed an… Continue reading A single bout of physical #exercise improves 1-hour post-load plasma #glucose in healthy young adults
#GLP-1 programs the neurovascular landscape
Readily available nutrient-rich foods exploit our inherent drive to overconsume, creating an environment of overnutrition. This transformative setting has led to persistent health issues, such as obesity and metabolic syndrome. The development of glucagon-like peptide-1 receptor (GLP-1R) agonists reveals our ability to pharmacologically manage weight and address metabolic conditions. Obesity is directly linked to chronic… Continue reading #GLP-1 programs the neurovascular landscape
#Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With Diabetes
Key PointsQuestion In older individuals with diabetes, is maintaining stability of glycated hemoglobin A1c levels (HbA1c) in individualized target ranges over time associated with lower risk of Alzheimer disease and related dementias (ADRD)?Findings In this cohort study of 374 021 older veterans with diabetes, greater HbA1c stability, as measured by HbA1c time in range, was associated… Continue reading #Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With Diabetes
2 Medical News 