In type 2 diabetes, insulin resistance and progressive β-cell failure require treatment with high insulin doses, leading to weight gain. Our aim was to study whether a three-meal diet (3Mdiet) with a carbohydrate-rich breakfast may upregulate clock gene expression and, as a result, allow dose reduction of insulin, leading to weight loss and better glycemic… Continue reading Reduction in Glycated Hemoglobin and Daily Insulin Dose Alongside Circadian Clock Upregulation in Patients With Type 2 #Diabetes Consuming a Three- #Meal Diet: A Randomized Clinical Trial
Category: Endocrinology
Maternal #diabetes during pregnancy and early onset of #cardiovascular disease in offspring: population based cohort study with 40 years of follow-up
To evaluate the associations between maternal diabetes diagnosed before or during pregnancy and early onset cardiovascular disease (CVD) in offspring during their first four decades of life. ..Offspring of mothers with diabetes had a 29% increased overall rate of early onset CVD (hazard ratio 1.29 (95% confidence interval 1.21 to 1.37); cumulative incidence among offspring… Continue reading Maternal #diabetes during pregnancy and early onset of #cardiovascular disease in offspring: population based cohort study with 40 years of follow-up
Prevalence of #Prediabetes Among #Adolescents and Young Adults in the United States, 2005-2016
.. Impaired fasting glucose was defined as fasting plasma glucose of 100 mg/dL to less than 126 mg/dL, IGT as 2-hour plasma glucose of 140 mg/dL to less than 200 mg/dL, and increased HbA1c level as HbA1c level between 5.7% and 6.4%. The prevalence of IFG, isolated IFG, IGT, isolated IGT, increased HbA1c level, isolated… Continue reading Prevalence of #Prediabetes Among #Adolescents and Young Adults in the United States, 2005-2016
#Dapagliflozin in Patients with Heart Failure and Reduced #Ejection Fraction
In patients with type 2 diabetes, inhibitors of sodium–glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose-independent mechanisms.. A first worsening heart failure event occurred in 237 patients (10.0%) in the dapagliflozin group and in 326 patients (13.7%) in the placebo group (hazard ratio, 0.70; 95% CI,… Continue reading #Dapagliflozin in Patients with Heart Failure and Reduced #Ejection Fraction
Altered Risk for #cardiovascular Events With Changes in the #Metabolic Syndrome Status: A Nationwide Population-Based Study of Approximately 10 Million Persons
Population-scale evidence for the association between dynamic changes in metabolic syndrome (MetS) status and alterations in the risk for major adverse cardiovascular events (MACE) is lacking ..At a median follow-up of 3.54 years, the MetS-recovery group (incidence rate, 4.55 per 1000 person-years) had a significantly lower MACE risk (adjusted IRR, 0.85 [95% CI, 0.83 to… Continue reading Altered Risk for #cardiovascular Events With Changes in the #Metabolic Syndrome Status: A Nationwide Population-Based Study of Approximately 10 Million Persons
Adjunctive #Rifampin Therapy For Diabetic Foot #Osteomyelitis in the Veterans Health Administration
Among patients diagnosed with diabetes, the lifetime incidence of foot ulcers is 15%. Infection is a common complication of foot ulcers, and 20% to 60% of infections result in diabetic foot osteomyelitis (DFO). ..Patients initiating rifampin therapy within 6 weeks of the DFO diagnosis and receiving the drug for at least 14 days within 90… Continue reading Adjunctive #Rifampin Therapy For Diabetic Foot #Osteomyelitis in the Veterans Health Administration
Association of #Testosterone Therapy With Risk of Venous #Thromboembolism Among Men With and Without #Hypogonadism
..A total of 39https://bit.ly/2qGlfy0622 men (mean [SD] age, 57.4 [14.2] years) were enrolled in the study, and 3110 men (7.8%) had evidence of hypogonadism. In age-adjusted models, testosterone therapy use in all case periods was associated with a higher risk of VTE in men with (odds ratio [OR], 2.32; 95% CI, 1.97-2.74) and without (OR,… Continue reading Association of #Testosterone Therapy With Risk of Venous #Thromboembolism Among Men With and Without #Hypogonadism
Association Between #Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical #Hypothyroidism
..The hypothyroid symptoms score decreased from 21.7 at baseline to 19.3 at 12 months in the levothyroxine group vs from 19.8 at baseline to 17.4 at 12 months in the placebo group (adjusted between-group difference, 1.3 [95% CI, −2.7 to 5.2]; P = .53). The tiredness score increased from 25.5 at baseline to 28.2 at 12 months… Continue reading Association Between #Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical #Hypothyroidism
Changes in Consumption of Sugary Beverages and Artificially #Sweetened Beverages and Subsequent Risk of Type 2 #Diabetes: Results From Three Large Prospective U.S. Cohorts of Women and Men
artificially sweetened beverages (ASBs) ..After adjustment for BMI and initial and changes in diet and lifestyle covariates, increasing total sugary beverage intake (including both sugar-sweetened beverages and 100% fruit juices) by >0.50 serving/day over a 4-year period was associated with a 16% (95% CI 1%, 34%) higher diabetes risk in the subsequent 4 years. Increasing… Continue reading Changes in Consumption of Sugary Beverages and Artificially #Sweetened Beverages and Subsequent Risk of Type 2 #Diabetes: Results From Three Large Prospective U.S. Cohorts of Women and Men
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