Messenger RNA (mRNA) vaccines against SARS-CoV-2 are highly effective and were instrumental in curbing the COVID-19 pandemic. However, rare cases of noninfective myocarditis, particularly in young males and typically after the second dose, have been observed. Here, we explore the mediators of this myocarditis to better understand and to enhance the safety of future mRNA… Continue reading Inhibition of CXCL10 and IFN-γ ameliorates #myocarditis in preclinical models of SARS-CoV-2 #mRNA vaccination
Category: Cardiology
Effects of #finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 #diabetes and chronic #kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR)
Background: The mechanisms underlying cardiorenal benefits of finerenone remain unclear. This mechanistic trial aimed to evaluate the effects of finerenone on vascular stiffness, as assessed using the cardio-ankle vascular index (CAVI), and cardiorenal biomarkers in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD).Methods: Eligible patients with T2D and CKD (estimated glomerular filtration… Continue reading Effects of #finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 #diabetes and chronic #kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR)
A six-year longitudinal study identifies a #statin -independent association between low LDL- #cholesterol and risk of type 2 #diabetes
Statin therapy has been associated with increased risk of type 2 diabetes (T2D). We investigated the relationship between Low-Density Lipoprotein Cholesterol (LDL-C) plasma concentrations and incident T2D and evaluated the modifying effect of statin therapy in a large population-based cohort.MethodsIndividuals free of T2D and cardiovascular disease at baseline were followed longitudinally for the development of… Continue reading A six-year longitudinal study identifies a #statin -independent association between low LDL- #cholesterol and risk of type 2 #diabetes
Factors associated with the failure to achieve nocturnal blood #pressure control
Background: The Hiroshima Registry for Evaluation and Treatment of Nocturnal and Early Morning Hypertension (Hiroshima NOCTURNE) was a prospective, multicenter study designed to determine whether elevated nighttime blood pressure (BP), assessed using a home BP monitoring (HBPM) device, can be normalized through active antihypertensive therapy in patients already receiving antihypertensive medication. In this subanalysis, we… Continue reading Factors associated with the failure to achieve nocturnal blood #pressure control
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial FibrillationThe DECAF Randomized Clinical Trial
Key PointsQuestion Does consumption of caffeinated coffee have a beneficial, detrimental, or neutral effect on the risk of recurrent atrial fibrillation (AF) episodes?Findings In this multicenter randomized clinical trial including 200 patients with persistent AF undergoing cardioversion, the risk of recurrent AF was significantly lower in the group allocated to coffee consumption (47%) compared with… Continue reading Caffeinated Coffee Consumption or Abstinence to Reduce Atrial FibrillationThe DECAF Randomized Clinical Trial
Real-World #Edoxaban Concentrations in #Older Patients Receiving Reduced-Dose Regimens
This study investigated real-world edoxaban concentrations across different dosing regimens, with a specific focus on patients who met the inclusion criteria of low-dose edoxaban for the Elder Care Atrial Fibrillation (ELDERCARE-AF) trial. Patients with atrial fibrillation receiving edoxaban were enrolled to measure trough concentrations. The levels were compared with the expected therapeutic range (12–43 ng/mL) to… Continue reading Real-World #Edoxaban Concentrations in #Older Patients Receiving Reduced-Dose Regimens
Dietary #flavanols preserve upper- and lower-limb endothelial function during #sitting in high- and low-fit young healthy males
Sedentary behaviour is very prevalent in modern societies, with young adults spending approximately 6 h/day sitting. Sitting induces declines in endothelial function, increasing the risk of cardiovascular diseases. Nutrition during sitting may be used as a strategy to minimise such effects. This acute randomised, counterbalanced, double-blinded, cross-over, placebo-controlled human study investigated whether intake of dietary… Continue reading Dietary #flavanols preserve upper- and lower-limb endothelial function during #sitting in high- and low-fit young healthy males
High-sensitivity cardiac #troponin I and risk of #dementia: the 25-year longitudinal Whitehall II study
Background and AimsThis study hypothesizes that subclinical myocardial injury during midlife, indexed by increases in cardiac troponin I, is associated with accelerated cognitive decline, smaller structural brain volume, and higher risk of dementia.MethodsOverall, 5985 participants in the Whitehall II study, aged 45–69 who had cardiac troponin I measured by a high-sensitivity assay at baseline (1997–99),… Continue reading High-sensitivity cardiac #troponin I and risk of #dementia: the 25-year longitudinal Whitehall II study
Association between frequency of meeting daily step thresholds and all-cause #mortality and #cardiovascular disease in older women
Objective To examine the associations between the number of days per week achieving various daily step thresholds and all-cause mortality and cardiovascular disease (CVD) incidence in older women.Methods We conducted a prospective cohort study of 13 547 women free of CVD and cancer (mean age 71.8 years). We included participants who wore an ActiGraph GT3X+ accelerometer for… Continue reading Association between frequency of meeting daily step thresholds and all-cause #mortality and #cardiovascular disease in older women
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