Background & aims: Aminotransferases are widely used for metabolic dysfunction-associated steatotic liver disease (MASLD) evaluation, especially in type 2 diabetes mellitus (T2DM). Whether within-person seasonal variation affects classification near commonly used thresholds or relates to long-term metabolic outcomes remains unclear.Methods: This registry-based cohort analysed monthly aspartate aminotransferase (AST) and alanine aminotransferase (ALT) measurements from 6039… Continue reading Within-Person Seasonal Variability of Aminotransferases and Long-Term Glycemic Control in Adults With Type 2 Diabetes (JDDM 85)
Tag: liver
Underlying MASLD-induced gut microbiome dysbiosis and intestinal inflammation are key to poor outcomes in vibriosis infections in a preclinical model
Metabolic dysfunction-associated steatotic liver disease (#MASLD ) is the leading cause of chronic #liver disease globally, especially in developed countries, including the United States. The etiology of MASLD is closely associated with several other cardiometabolic conditions and can further aggravate to more severe stages of liver disease, including steatohepatitis and cirrhosis. Moreover, patients with underlying… Continue reading Underlying MASLD-induced gut microbiome dysbiosis and intestinal inflammation are key to poor outcomes in vibriosis infections in a preclinical model
Temporal trends in hepatic steatosis and its risk factors among young adults: A comparative cohort study
Metabolic-dysfunction-associated steatotic liver disease (#MASLD ) is increasingly affecting younger populations worldwide, yet early-phase data from low-risk, health-literate groups remain limited. This study aimed to evaluate temporal changes in the prevalence and risk factors of hepatic steatosis among medical students across two cohorts 6 years apart.Methods: We enrolled 489 medical students from King Saud University… Continue reading Temporal trends in hepatic steatosis and its risk factors among young adults: A comparative cohort study
Naproxen as a cause of acute cholestatic hepatitis: a case report
Drug-induced liver injury is a common cause of acute liver injury and acute liver failure worldwide, and nonsteroidal antiinflammatory drugs are the third most common pharmaceutical group related with its development. Between nonsteroidal antiinflammatory drugs, naproxen is a propionic derivate widely used and generally safe drug.Case presentationWe present an 83 year-old Caucasian male patient with… Continue reading Naproxen as a cause of acute cholestatic hepatitis: a case report
Characteristics and outcomes of patients with #HCC treated with atezolizumab/bevacizumab, stratified by second line therapy
Background: Atezolizumab plus bevacizumab (atezo+bev) is a standard-of-care 1L treatment for unresectable hepatocellular carcinoma (uHCC). Understanding its adoption and use, clinical outcomes, and subsequent therapies are needed.Methods: This retrospective cohort study included 550 patients with u #HCC in the US who initiated 1L atezo+bev between June 2020 and April 2023. Medical records were abstracted to… Continue reading Characteristics and outcomes of patients with #HCC treated with atezolizumab/bevacizumab, stratified by second line therapy
#Artificial #Intelligence and #Machine #Learning Applications in #Liver Disease
AbstractArtificial intelligence and machine learning are transforming hepatology by integrating clinical, laboratory, imaging, and wearable data for earlier diagnosis, risk prediction, and patient management. These technologies enable personalized care and noninvasive monitoring across metabolic dysfunction-associated steatotic liver disease, cirrhosis, hepatitis C, liver transplantation, and hepatocellular carcinoma. Ongoing advances in digital health and interpretability will enhance… Continue reading #Artificial #Intelligence and #Machine #Learning Applications in #Liver Disease
#Coffee for the #liver: a mechanistic approach
The liver, which is essential for metabolism and detoxification, is vulnerable to various damaging factors, including viral infections, excessive alcohol consumption, and a diet high in fat and sugar. Coffee, one of the most widely consumed beverages worldwide, is valued not only for its flavor and aroma but also for its potential health benefits. In… Continue reading #Coffee for the #liver: a mechanistic approach
Undiagnosed #Cirrhosis and Hepatic #Encephalopathy in a National Cohort of Veterans With #Dementia
Dementia and hepatic encephalopathy (HE) are challenging to distinguish clinically. Undiagnosed cirrhosis in a patient with dementia can lead to missed opportunities to treat HE.Objective To examine the prevalence and risk factors of undiagnosed cirrhosis and therefore possible HE in veterans with dementia.Design, Setting, and Participants A retrospective cohort study was conducted between 2009 and 2019 using… Continue reading Undiagnosed #Cirrhosis and Hepatic #Encephalopathy in a National Cohort of Veterans With #Dementia
ACG Clinical Guideline: #Alcohol-Associated #Liver Disease
Alcohol-associated liver disease (ALD) is the most common cause of advanced hepatic disease and frequent indication for liver transplantation worldwide. With harmful alcohol use as the primary risk factor, increasing alcohol use over the past decade has resulted in rapid growth of the ALD-related healthcare burden. The spectrum of ALD ranges from early asymptomatic liver… Continue reading ACG Clinical Guideline: #Alcohol-Associated #Liver Disease
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