The association of early life adversities and psychosis symptoms is well documented in clinical populations; however, whether this relationship also extends into subclinical psychosis remains unclear. In particular, are early life adversities associated with increased levels of schizotypal personality traits in non-clinical samples? We conducted a systematic review and meta-analysis of associations between early life… Continue reading Childhood trauma and schizotypy in non-clinical samples: A systematic review and meta-analysis
Tag: schizophrenia
Association Between Genetic Risk for #Psychiatric Disorders and the Probability of Living in #Urban Settings
Urban residence has been highlighted as an environmental risk factor for schizophrenia and, to a lesser extent, several other psychiatric disorders. However, few studies have explored genetic effects on the choice of residence. Objective To investigate whether individuals with genetic predisposition to a range of psychiatric disorders have an increased likelihood to live in urban… Continue reading Association Between Genetic Risk for #Psychiatric Disorders and the Probability of Living in #Urban Settings
Association of #Mitochondrial Biogenesis With Variable Penetrance of #Schizophrenia
Discovery of mechanisms that underlie variable penetrance for neuropsychiatric illness in the context of genetic variants that carry elevated risk can advance novel treatment approaches for these disorders. Objective To test the hypothesis that mitochondrial compensation is associated with the variable penetrance of schizophrenia in the 22q11.2 deletion syndrome (22q11DS). Design, Setting, and Participants This… Continue reading Association of #Mitochondrial Biogenesis With Variable Penetrance of #Schizophrenia
#Disruption of the blood−brain barrier in 22q11.2 deletion syndrome
Neuroimmune dysregulation is implicated in neuropsychiatric disorders including schizophrenia. As the blood−brain barrier is the immunological interface between the brain and the periphery, we investigated whether this vascular phenotype is intrinsically compromised in the most common genetic risk factor for schizophrenia, the 22q11.2 deletion syndrome (22qDS). Blood−brain barrier like endothelium differentiated from human 22qDS+schizophrenia-induced pluripotent… Continue reading #Disruption of the blood−brain barrier in 22q11.2 deletion syndrome
Increased Risk of #Parkinson’s Disease in Patients With #Schizophrenia Spectrum Disorders
PD comorbid with schizophrenia has been considered rare because these diseases associate with opposite alterations in the brain dopamine system. The objective of this study was to investigate the risk of PD after a diagnosis of a schizophrenia spectrum disorder. Methods Regionally, this was a retrospective record‐based case–control study. The cohort included 3045 PD patients… Continue reading Increased Risk of #Parkinson’s Disease in Patients With #Schizophrenia Spectrum Disorders
#ABCA13 dysfunction associated with #psychiatric disorders causes impaired cholesterol trafficking
ATP-binding cassette subfamily A member 13 (ABCA13) is predicted to be the largest ABC protein, consisting of 5,058 amino acids and a long N-terminal region. Mutations in the ABCA13 gene were reported to increase the susceptibility to schizophrenia, bipolar disorder and major depression. However, little is known about the molecular functions of ABCA13 or how… Continue reading #ABCA13 dysfunction associated with #psychiatric disorders causes impaired cholesterol trafficking
Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care
Evaluate efficacy and safety of a 2-month formulation of aripiprazole lauroxil (AL) with 1-day initiation during hospitalization for acute exacerbation of schizophrenia followed by transition to outpatient care.. The phase 3b double-blind Aripiprazole Lauroxil and Paliperidone palmitate: INitiation Effectiveness (ALPINE) study was conducted from November 2017 to March 2019. Adults with acute schizophrenia according to… Continue reading Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care
Early- Versus Adult-Onset #Schizophrenia as a Predictor of Response to Neuroscience-Informed Cognitive Training
Developmental stages characterized by greater neural plasticity might be critical periods during which the effects of cognitive training (CT) could theoretically be maximized. However, experiencing a first episode of schizophrenia during childhood or adolescence (ie, early-onset schizophrenia [EOS]) may reduce the brain’s ability to benefit from CT. This study examined the effects of EOS versus… Continue reading Early- Versus Adult-Onset #Schizophrenia as a Predictor of Response to Neuroscience-Informed Cognitive Training
Shared Genetic Loci Between Body #Mass Index and Major #Psychiatric Disorders A Genome-wide Association Study
People with major psychiatric disorders (MPDs) have a 10- to 20-year shorter life span than the rest of the population, and this difference is mainly due to comorbid cardiovascular diseases.. schizophrenia (SCZ), bipolar disorder (BIP), major depression (MD) body mass index (BMI) ..Of the shared loci, 34% (73 of 213) in SCZ, 52% (36 of… Continue reading Shared Genetic Loci Between Body #Mass Index and Major #Psychiatric Disorders A Genome-wide Association Study
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