Tag: Nanoparticles

#Teabag-derived micro/#nanoplastics (true-to-life MNPLs) as a surrogate for real-life exposure scenarios

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Highlights•Nanoplastics were obtained from three teabag brands during a standard preparation.•ATR-FTIR shows nylon, polypropylene, and cellulose as constituents.•MNPLs release was higher for propylene and lower for nylon.•Uptake in Caco-2, HT29, and HT29-MTX human intestinal cells was determined.•Cell uptake depends on both cell type and chemical constitution of released MNPLs. AbstractThe potential health implications of environmental… Continue reading #Teabag-derived micro/#nanoplastics (true-to-life MNPLs) as a surrogate for real-life exposure scenarios

#Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in #Liver Tumors in Mice

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Immune checkpoint inhibitors have shed light on the importance of antitumor immunity as a therapeutic strategy for hepatocellular carcinoma (HCC). The altered glucose metabolism known as the Warburg effect recently has gained attention as a cancer immune-resistance mechanism. Considering glycolysis inhibitors as therapeutic agents, their specific delivery to cancer cells is critical not to induce… Continue reading #Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in #Liver Tumors in Mice

BBB pathophysiology–independent delivery of siRNA in traumatic #brain injury

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Small interfering RNA (siRNA)–based therapeutics can mitigate the long-term sequelae of traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier (BBB). One approach to overcoming this challenge involves treatment administration while BBB is transiently breached after injury. However, it offers a limited window for therapeutic intervention and is applicable to only… Continue reading BBB pathophysiology–independent delivery of siRNA in traumatic #brain injury

#Nanoparticle-induced #neutrophil apoptosis increases survival in #sepsis and alleviates neurological damage in #stroke

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Human neutrophils are the most abundant circulating leukocytes and contribute to acute and chronic inflammatory disorders. Neutrophil apoptosis is programed cell death to maintain immune homeostasis, but inflammatory responses to infections or tissue injury disrupt neutrophil death program, leading to many diseases. Precise control of neutrophil apoptosis may resolve inflammation to return immune homeostasis. Here,… Continue reading #Nanoparticle-induced #neutrophil apoptosis increases survival in #sepsis and alleviates neurological damage in #stroke