AbstractArtificial intelligence and machine learning are transforming hepatology by integrating clinical, laboratory, imaging, and wearable data for earlier diagnosis, risk prediction, and patient management. These technologies enable personalized care and noninvasive monitoring across metabolic dysfunction-associated steatotic liver disease, cirrhosis, hepatitis C, liver transplantation, and hepatocellular carcinoma. Ongoing advances in digital health and interpretability will enhance… Continue reading #Artificial #Intelligence and #Machine #Learning Applications in #Liver Disease
Tag: liver
#Coffee for the #liver: a mechanistic approach
The liver, which is essential for metabolism and detoxification, is vulnerable to various damaging factors, including viral infections, excessive alcohol consumption, and a diet high in fat and sugar. Coffee, one of the most widely consumed beverages worldwide, is valued not only for its flavor and aroma but also for its potential health benefits. In… Continue reading #Coffee for the #liver: a mechanistic approach
Undiagnosed #Cirrhosis and Hepatic #Encephalopathy in a National Cohort of Veterans With #Dementia
Dementia and hepatic encephalopathy (HE) are challenging to distinguish clinically. Undiagnosed cirrhosis in a patient with dementia can lead to missed opportunities to treat HE.Objective To examine the prevalence and risk factors of undiagnosed cirrhosis and therefore possible HE in veterans with dementia.Design, Setting, and Participants A retrospective cohort study was conducted between 2009 and 2019 using… Continue reading Undiagnosed #Cirrhosis and Hepatic #Encephalopathy in a National Cohort of Veterans With #Dementia
ACG Clinical Guideline: #Alcohol-Associated #Liver Disease
Alcohol-associated liver disease (ALD) is the most common cause of advanced hepatic disease and frequent indication for liver transplantation worldwide. With harmful alcohol use as the primary risk factor, increasing alcohol use over the past decade has resulted in rapid growth of the ALD-related healthcare burden. The spectrum of ALD ranges from early asymptomatic liver… Continue reading ACG Clinical Guideline: #Alcohol-Associated #Liver Disease
Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
Hepatobiliary cancers share risk factors with colorectal cancer (CRC), but there are no combined screening programs for these conditions.AimsThe aim of this study was to assess whether patients with high-risk colonic polyps are more likely to die from liver related tumors than patients with a negative colonoscopy.MethodsIn this retrospective analysis of mortality data, Austrian screening… Continue reading Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
Jaundice: Understanding The Yellowing Of The Skin And Eyes
Jaundice: Understanding The Yellowing Of The Skin And Eyes Introduction Jaundice is a medical condition characterized by the yellowing of the skin, eyes, and mucous membranes. It occurs due to an excess of bilirubin, a yellow pigment produced during the breakdown of red blood cells. Jaundice can be a sign of underlying medical issues and… Continue reading Jaundice: Understanding The Yellowing Of The Skin And Eyes
Ten-Year Outcomes of Liver Transplant and Downstaging for Hepatocellular Carcinoma
National guidelines on transplant selection have adopted successful downstaging to within Milan criteria (MC) as a viable option for the treatment of hepatocellular carcinoma (HCC) before liver transplant (LT). Recurrence of HCC after LT carries a poor prognosis, and treatment modalities remain challenging.Objective To establish the 10-year outcomes of patients with HCC after LT in… Continue reading Ten-Year Outcomes of Liver Transplant and Downstaging for Hepatocellular Carcinoma
Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma
AbstractWhile inflammatory mechanisms driving hepatocellular carcinoma (HCC) had been proposed, the regulators of anti-cancer immunity in HCC remain poorly understood. We found that IL-27 receptor (IL-27R) signaling promotes HCC development in vivo. High IL-27EBI3 cytokine or IL-27RA expression correlated with poor prognosis for patients with HCC. Loss of IL-27R suppressed HCC in vivo in two… Continue reading Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma
Quantified integrated hepatitis B virus is related to viral activity in chronic hepatitis B patients
AbstractBackground & AimsThe hepatitis B virus (HBV) can integrate in the host genome of the hepatocyte and recent findings suggest that integrated HBV contributes to the persistent production of viral proteins. Here we quantified the levels of integrated HBV in chronic hepatitis B (CHB) patients, and analysed the relation between HBV integration, virological activity (plasma… Continue reading Quantified integrated hepatitis B virus is related to viral activity in chronic hepatitis B patients
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