Glucagon-like peptide-1 (GLP-1) is an intestinally derived incretin that plays a vital role in engineering the biological circuit involved in treating type 2 diabetes. Exceedingly short half-life (1–2 min) of GLP-1 limits its therapeutic applicability, and the implication of its new variants is under question. Since albumin-binding DARPin as a mimetic molecule has been reported to… Continue reading Designing and computational analyzing of chimeric long-lasting #GLP-1 receptor agonists for type 2 #diabetes
Tag: Diabetes
Use of #sugar in #coffee and #tea and long-term risk of #mortality in older adult Danish men: 32 years of follow-up from a prospective cohort study
Tea and coffee are the most consumed beverages worldwide and very often sweetened with sugar. However, the association between the use of sugar in tea or coffee and adverse events is currently unclear.ObjectivesTo investigate the association between the addition of sugar to coffee or tea, and the risk of all-cause mortality, cardiovascular mortality, cancer mortality… Continue reading Use of #sugar in #coffee and #tea and long-term risk of #mortality in older adult Danish men: 32 years of follow-up from a prospective cohort study
Mechanisms of #weight loss-induced remission in people with #prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS)
Background Remission of type 2 diabetes can occur as a result of weight loss and is characterised by liver fat and pancreas fat reduction and recovered insulin secretion. In this analysis, we aimed to investigate the mechanisms of weight loss- induced remission in people with prediabetes.MethodsIn this prespecified post-hoc analysis, weight loss-induced resolution of prediabetes… Continue reading Mechanisms of #weight loss-induced remission in people with #prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS)
#Semaglutide in Early Type 1 #Diabetes
In this small case series, semaglutide after the diagnosis of type 1 diabetes led to elimination of prandial insulin in all patients and basal insulin in most, along with improved glycemic control. https://www.nejm.org/doi/full/10.1056/NEJMc2302677
#Kombucha tea as an anti-hyperglycemic agent in humans with #diabetes – a randomized controlled pilot investigation
Introduction: Kombucha is a popular fermented tea that has attracted considerable attention due, in part, to its suggested health benefits. Previous results from animal models led us to hypothesize kombucha may reduce blood sugar levels in humans with diabetes. The objective of this pilot clinical study was to evaluate kombucha for its anti-hyperglycemic activities in adults… Continue reading #Kombucha tea as an anti-hyperglycemic agent in humans with #diabetes – a randomized controlled pilot investigation
#Ultra-processed #food consumption is associated with all-cause and #cardiovascular mortality in participants with type 2 #diabetes independent of diet quality: a prospective observational cohort study
BackgroundNutritional strategies for prevention and management of type 2 diabetes traditionally emphasize dietary patterns reflecting nutrient goals, but the health implications of ultra-processed food (UPF) for patients with type 2 diabetes remain unknown.ObjectiveTo evaluate the association of UPF intake with all-cause and cardiovascular disease (CVD) mortality amongst participants with type 2 diabetes from the Moli-sani… Continue reading #Ultra-processed #food consumption is associated with all-cause and #cardiovascular mortality in participants with type 2 #diabetes independent of diet quality: a prospective observational cohort study
Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes
The additional therapeutic effects of regular exercise during a dietary weight loss program in people with obesity and prediabetes are unclear. Here, we show that whole-body (primarily muscle) insulin sensitivity (primary outcome) was 2-fold greater (P = 0.006) after 10% weight loss induced by calorie restriction plus exercise training (Diet+EX; n = 8, 6 women) than 10% weight loss induced… Continue reading Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes
Once-Weekly Insulin Icodec vs Once-Daily Insulin Degludec in Adults With Insulin-Naive Type 2 DiabetesThe ONWARDS 3 Randomized Clinical Trial
Once-weekly insulin icodec could provide a simpler dosing alternative to daily basal insulin in people with type 2 diabetes.Objective To evaluate the efficacy and safety of once-weekly icodec vs once-daily insulin degludec in people with insulin-naive type 2 diabetes.Design, Setting, and Participants Randomized, double-masked, noninferiority, treat-to-target, phase 3a trial conducted from March 2021 to June 2022 at… Continue reading Once-Weekly Insulin Icodec vs Once-Daily Insulin Degludec in Adults With Insulin-Naive Type 2 DiabetesThe ONWARDS 3 Randomized Clinical Trial
Can Circadian Eating Pattern Adjustments Reduce Risk or Prevent Development of T2D?
Type 2 diabetes (T2D) is a chronic condition that occurs in insulin-resistant people with reduced glucose uptake. It is contributed to and exacerbated by a poor diet that results in accumulation of adipose tissue, high blood sugar, and other metabolic issues. Because humans have undergone food scarcity throughout history, our species has adapted a fat… Continue reading Can Circadian Eating Pattern Adjustments Reduce Risk or Prevent Development of T2D?
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