Yue, Luo, and colleagues discovered that adenosine signalling is the common underlying mechanism of rapid acting antidepressant therapies, unifying the effects of ketamine, ECT and acute intermittent hypoxia. They use genetically encoded sensors, along with extensive mechanistic dissection, to show that all three induce adenosine surges in mood-regulatory circuits via A1 and A2A receptor activation.… Continue reading #Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
Tag: depression
#Acupuncture for Major #Depressive Disorder: Exploring the #Gut Microbiota as a Novel Therapeutic Pathway
This study investigates the efficacy of acupuncture at Baihui (GV20) and Zusanli (ST36) acupoints in alleviating depressive symptoms and elucidates the underlying mechanisms.MethodsSixty male C57BL/6J mice were subjected to an 8-week chronic unpredictable mild stress (CUMS) paradigm. Acupuncture was administered to two groups during the final 3 weeks: one under CUMS and the other without… Continue reading #Acupuncture for Major #Depressive Disorder: Exploring the #Gut Microbiota as a Novel Therapeutic Pathway
#Mineral Intake and #Depression: A Cross-Sectional Comparative Study Based on National Health and Nutrition Examination Surveys in Korea and the United States
Background/Objectives: Depression is a major global health burden, and previous studies suggest that nutrient deficiencies may contribute to its development. However, research on mineral intake and depression, particularly sodium and potassium, is limited. We conducted a cross-sectional analysis of data from the National Health and Nutrition Examination Survey in Korea (KNHANES) and the United States… Continue reading #Mineral Intake and #Depression: A Cross-Sectional Comparative Study Based on National Health and Nutrition Examination Surveys in Korea and the United States
#Limbic gray matter increases in response to #cognitive-behavioral therapy in major #depressive disorder
Major depressive disorder (MDD) is related to volumetric decreases in (cortico-)limbic brain regions. In contrast to pharmacological and electroconvulsive therapy, little is known about the brain structural effects of psychotherapy and potential links to symptom improvements. In a naturalistic longitudinal study using structural magnetic resonance tomography, gray matter volume (GMV) and clinical measures were assessed… Continue reading #Limbic gray matter increases in response to #cognitive-behavioral therapy in major #depressive disorder
#Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial
BackgroundNon-remission after psychological therapy for major depressive disorder is common, yet there are no established further-line treatments. In the UK National Health Service (NHS) Talking Therapies programme, about 50% of patients with depression who come to the end of the stepped care pathway do not show remission of symptoms. We aimed to investigate whether mindfulness-based… Continue reading #Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial
Postpartum Hormonal #Contraceptive Use and Risk of #Depression
AbstractImportance Hormonal contraceptive (HC) use is associated with depression. It is, however, unknown whether this is also true in the postpartum period when women have a heightened depression risk and are routinely offered HC treatment.Objective To examine whether HC initiation post partum is associated with the development of depression within 12 months post partum.Design, Setting,… Continue reading Postpartum Hormonal #Contraceptive Use and Risk of #Depression
High- #salt #diet drives depression-like behavior in mice by inducing IL-17A production
Major depression disorder is a common illness that severely limits psychosocial functioning, affects outcomes of other diseases, and diminishes the quality of life. High-salt diet (HSD) has long been closely associated with the occurrence and development of depression, but whether or how HSD causes depression remains unclear. In this study, HSD induces depression-like behavior in… Continue reading High- #salt #diet drives depression-like behavior in mice by inducing IL-17A production
Glucagon-Like Peptide-1 Receptor Agonists and Risk for #Depression in Older Adults With Type 2 #Diabetes
Background:Although glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown potential antidepressant effects, population studies yield inconsistent results. Objective:To compare the risk for depression in older adults with type 2 diabetes (T2D) initiating treatment with GLP-1RAs versus sodium–glucose cotransporter-2 inhibitors (SGLT2is) or dipeptidyl peptidase-4 inhibitors (DPP4is).Design:Target trial emulation study.Setting:U.S. National Medicare administrative data from January 2014 to… Continue reading Glucagon-Like Peptide-1 Receptor Agonists and Risk for #Depression in Older Adults With Type 2 #Diabetes
Real-Time Assessment of #Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and #Depressive Disorders
Objective:The allostasis theory states that, as addiction develops, alcohol is consumed to relieve negative affect rather than to produce positive effects. This study aimed to investigate the real-time subjective effects of alcohol in individuals with alcohol use disorder (AUD) and those prone to negative affect by virtue of having comorbid depressive disorder (DEP).Methods:Participants (N=221) completed… Continue reading Real-Time Assessment of #Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and #Depressive Disorders
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