Healthy Prenatal #Dietary Pattern and Offspring #Autism

Question  What is the association between a healthy prenatal dietary pattern and offspring autism diagnosis and autism-associated traits in 2 large prospective cohort studies: the Norwegian Mother, Father, and Child Cohort (MoBa) and the Avon Study of Parents and Children (ALSPAC)?Findings  In this cohort study including 84 548 mother-infant dyads in MoBa and 11 670 mother-infant dyads in ALSPAC,… Continue reading Healthy Prenatal #Dietary Pattern and Offspring #Autism

Multikingdom and functional gut #microbiota markers for #autism spectrum disorder

Associations between the gut microbiome and autism spectrum disorder (ASD) have been investigated although most studies have focused on the bacterial component of the microbiome. Whether gut archaea, fungi and viruses, or function of the gut microbiome, is altered in ASD is unclear. Here we performed metagenomic sequencing on faecal samples from 1,627 children (aged… Continue reading Multikingdom and functional gut #microbiota markers for #autism spectrum disorder

Modifications of Behavior and Inflammation in Mice Following Transplant with Fecal Microbiota from Children with Autism

Highlights•Modifications of behavior and inflammatory factors in mice gut-brain axis.•Key role of gut microbiota during the different developmental phases of ASD.•Fecal microbiota transplant improves ASD symptoms.AbstractAutism spectrum disorder (ASD) is a neurodevelopmental disorder displaying the modification of complex human behaviors, characterized by social interaction impairments, stereotypical/repetitive activities and emotional dysregulation. In this study, fecal microbiota… Continue reading Modifications of Behavior and Inflammation in Mice Following Transplant with Fecal Microbiota from Children with Autism

Early childhood allergy linked with development of attention deficit hyperactivity disorder and autism spectrum disorder

BackgroundPrevious studies reported controversial results regarding the association between allergic disorders and attention deficit hyperactivity disorder (ADHD)/autism spectrum disorder (ASD). The aim of this article was to investigate whether allergic disorders are associated with ADHD/ASD in a large cohort of pediatric patients. MethodsA retrospective study using the pediatric (0–18 year) database (ICD-9-CM codes) of Clalit Health… Continue reading Early childhood allergy linked with development of attention deficit hyperactivity disorder and autism spectrum disorder

Association Between Screen Time Exposure in Children at 1 Year of Age and Autism Spectrum Disorder at 3 Years of AgeThe Japan Environment and Children’s Study

It is unclear to what extent the duration of screen time in infancy is associated with the subsequent diagnosis of autism spectrum disorder. Objective To examine the association between screen time in infancy and the development of autism spectrum disorder at 3 years of age. Design, Setting, and Participants This cohort study analyzed data from… Continue reading Association Between Screen Time Exposure in Children at 1 Year of Age and Autism Spectrum Disorder at 3 Years of AgeThe Japan Environment and Children’s Study

Association Between #Epidural Analgesia During Labor and Risk of #Autism Spectrum Disorders in Offspring

Although the safety of labor epidural analgesia (LEA) for neonates has been well documented, the long-term health effects of LEA on offspring remain to be investigated... ..Among the cohort of 147 895 singleton children (74 425 boys [50.3%]; mean [SD] gestational age at delivery, 38.9 [1.5] weeks), 109 719 (74.2%) were exposed to maternal LEA. Fever during labor… Continue reading Association Between #Epidural Analgesia During Labor and Risk of #Autism Spectrum Disorders in Offspring

Relationship Among Sensory Over-Responsivity, Problem Behaviors, and #Anxiety in Emerging Adults with #Autism Spectrum Disorder

Despite the highly prevailing rate of sensory over-responsivity, problem behaviors, and anxiety among emerging adults with autism spectrum disorder (ASD), little is known about the nature of their experiences. While previous studies have indicated potential relationships among these conditions, their connections still need to be clarified. This study aimed to examine the relationships between sensory… Continue reading Relationship Among Sensory Over-Responsivity, Problem Behaviors, and #Anxiety in Emerging Adults with #Autism Spectrum Disorder

Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder

Major recommendations (Level B) For children and adolescents with ASD and sleep disturbance, clinicians should assess for medications and coexisting conditions that could contribute to the sleep disturbance and should address identified issues. Clinicians should counsel parents regarding strategies for improved sleep habits with behavioral strategies as a first-line treatment approach for sleep disturbance either… Continue reading Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder

Behavioral effects of multiple-dose #oxytocin treatment in #autism: a randomized, placebo-controlled trial with long-term follow-up

Intranasal administration of the “prosocial” neuropeptide oxytocin is increasingly explored as a potential treatment for targeting the core characteristics of autism spectrum disorder (ASD).. ..Among the secondary outcome measures, treatment-specific improvements were identified in the Repetitive Behavior Scale and State Adult Attachment Measure, indicating reductions in self-reported repetitive behaviors (p = .04) and reduced feelings… Continue reading Behavioral effects of multiple-dose #oxytocin treatment in #autism: a randomized, placebo-controlled trial with long-term follow-up