Parkinson’s disease is a progressive neurodegenerative movement disorder with a long latent phase and currently no disease-modifying treatments. Reliable predictive biomarkers that could transform efforts to develop neuroprotective treatments remain to be identified. Using UK Biobank, we investigated the predictive value of accelerometry in identifying prodromal Parkinson’s disease in the general population and compared this… Continue reading Wearable movement-tracking data identify Parkinson’s disease years before clinical diagnosis
Category: Tech
Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial
The clinical value of using digital tools to assess adherence and lung function in uncontrolled asthma is not known. We aimed to compare treatment decisions guided by digitally acquired data on adherence, inhaler technique, and peak flow with existing methods.MethodsA 32-week prospective, multicentre, single-blinded, parallel, randomly controlled trial was done in ten severe asthma clinics… Continue reading Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial
Mobile phone calls, genetic susceptibility, and new-onset hypertension: results from 212 046 UK Biobank participants
The relationship between mobile phone use for making or receiving calls and hypertension risk remains uncertain. We aimed to examine the associations of mobile phone use for making or receiving calls and the use frequency with new-onset hypertension in the general population, using data from the UK Biobank.Methods and resultsA total of 212 046 participants… Continue reading Mobile phone calls, genetic susceptibility, and new-onset hypertension: results from 212 046 UK Biobank participants
Bioelectronic microfluidic wound healing: a platform for investigating direct current stimulation of injured cell collectives
Upon cutaneous injury, the human body naturally forms an electric field (EF) that acts as a guidance cue for relevant cellular and tissue repair and reorganization. However, the direct current (DC) flow imparted by this EF can be impacted by a variety of diseases. This work delves into the impact of DC stimulation on both… Continue reading Bioelectronic microfluidic wound healing: a platform for investigating direct current stimulation of injured cell collectives
Examining understandability, information quality, and presence of misinformation in popular YouTube videos on sleep compared to expert-led videos
The Internet is a common source of sleep information, but may be subject to commercial bias and misinformation. We compared the understandability, information quality, and presence of misinformation of popular YouTube videos on sleep to videos with credible experts. We identified the most popular YouTube videos on sleep/insomnia and 5 videos from experts. Videos were… Continue reading Examining understandability, information quality, and presence of misinformation in popular YouTube videos on sleep compared to expert-led videos
Effect of Technology-Enhanced Screening in Addition to Standard Targeted Clinician Education on the Duration of Untreated PsychosisA Cluster Randomized Clinical Trial
Reducing the duration of untreated psychosis (DUP) is essential to improving outcomes for people with first-episode psychosis (FEP). Current US approaches are insufficient to reduce DUP to international standards of less than 90 days.Objective To determine whether population-based electronic screening in addition to standard targeted clinician education increases early detection of psychosis and decreases DUP,… Continue reading Effect of Technology-Enhanced Screening in Addition to Standard Targeted Clinician Education on the Duration of Untreated PsychosisA Cluster Randomized Clinical Trial
Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets
Antibody delivery to the CNS remains a huge hurdle for the clinical application of antibodies targeting a CNS antigen. The blood–brain barrier and blood–CSF barrier restrict access of therapeutic antibodies to their CNS targets in a major way. The very high amounts of therapeutic antibodies that are administered systemically in recent clinical trials to reach… Continue reading Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets
Association Between In-Person vs Telehealth Follow-up and Rates of Repeated Hospital Visits Among Patients Seen in the Emergency Department
Importance For patients discharged from the emergency department (ED), timely outpatient in-person follow-up is associated with improved mortality, but the effectiveness of telehealth as follow-up modality is unknown.Objective To evaluate whether the rates of ED return visits and hospitalization differ between patients who obtain in-person vs telehealth encounters for post-ED follow-up care.Design, Setting, and Participants This retrospective cohort… Continue reading Association Between In-Person vs Telehealth Follow-up and Rates of Repeated Hospital Visits Among Patients Seen in the Emergency Department
Ultrasonography in the prediction of gout flares: a 12-month prospective observational study
ObjectivesTo evaluate whether US findings indicating MSU deposits and US-detected inflammation (i.e. power Doppler signal) predict gout flares over 12 months.MethodsGout patients on urate-lowering therapy for at least the preceding 6 months were enrolled consecutively in this 12-month prospective, observational, single-centre study. A nested case–control analysis was performed. Cases were participants with at least one flare in… Continue reading Ultrasonography in the prediction of gout flares: a 12-month prospective observational study
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