Psilocybin may have antidepressant properties, but direct comparisons between psilocybin and established treatments for depression are lacking. METHODS In a phase 2, double-blind, randomized, controlled trial involving patients with long-standing, moderate-to-severe major depressive disorder, we compared psilocybin with escitalopram, a selective serotonin-reuptake inhibitor, over a 6-week period. Patients were assigned in a 1:1 ratio to… Continue reading Trial of #Psilocybin versus #Escitalopram for Depression
Category: Psychiatry
Neurocognitive processing efficiency for discriminating human non-alarm rather than alarm scream calls
Across many species, scream calls signal the affective significance of events to other agents. Scream calls were often thought to be of generic alarming and fearful nature, to signal potential threats, with instantaneous, involuntary, and accurate recognition by perceivers. However, scream calls are more diverse in their affective signaling nature than being limited to fearfully… Continue reading Neurocognitive processing efficiency for discriminating human non-alarm rather than alarm scream calls
#Income robustly predicts self-regard #emotions
There is robust evidence that higher income makes people evaluate their lives more favorably, but there is no consistent evidence on whether it makes people feel better. Analyzing data from five large surveys spanning 162 countries, we predicted and found the most comprehensive evidence to date that income reliably predicted greater positive self-regard emotions (e.g.,… Continue reading #Income robustly predicts self-regard #emotions
Acute cognitive effects of single-dose intravenous #ketamine in major #depressive and posttraumatic stress disorder
Intravenous (IV) subanesthetic doses of ketamine have been shown to reduce psychiatric distress in both major depressive (MDD) and posttraumatic stress disorder (PTSD). However, the effect of ketamine on cognitive function in these disorders is not well understood. To address this gap, we examined the effect of a single dose of IV ketamine on cognition… Continue reading Acute cognitive effects of single-dose intravenous #ketamine in major #depressive and posttraumatic stress disorder
6-month neurological and #psychiatric outcomes in 236 379 survivors of #COVID-19: a retrospective cohort study using electronic health records
Summary Background Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric diagnoses in patients in the 6 months following a COVID-19 diagnosis. Methods For… Continue reading 6-month neurological and #psychiatric outcomes in 236 379 survivors of #COVID-19: a retrospective cohort study using electronic health records
#Obesity and Responsiveness to #Food Marketing Before and After #Bariatric Surgery
Although food marketing is often accused of increasing population obesity, the relationship between individual responsiveness to marketing and obesity has yet to be established: Are people with obesity more responsive to food marketing and, if so, is it a stable trait or can it be reversed by bariatric surgery? We studied the responses to three… Continue reading #Obesity and Responsiveness to #Food Marketing Before and After #Bariatric Surgery
#Cocoa Flavanols Improve Vascular Responses to Acute Mental #Stress in Young Healthy Adults
Mental stress has been shown to induce cardiovascular events, likely due to its negative impact on vascular function. Flavanols, plant-derived polyphenolic compounds, improve endothelial function and blood pressure (BP) in humans, however their effects during stress are not known. This study examined the effects of acute intake of cocoa flavanols on stress-induced changes on vascular… Continue reading #Cocoa Flavanols Improve Vascular Responses to Acute Mental #Stress in Young Healthy Adults
Jumping to conclusions and #suicidal behavior in #depression and #psychosis
Highlights • Presence of JTC is higher in depressive and psychotic patients with history of SB, specially under ambiguous conditions. • Within individuals who exhibited JTC, more had a diagnosis of depression than psychosis, and that is related to older age. • JTC might be considered a transdiagnostic construct present in different psychiatric disorders. Abstract… Continue reading Jumping to conclusions and #suicidal behavior in #depression and #psychosis
Associations between adolescent #cannabis use and young-adult functioning in three longitudinal twin studies
Observational studies have linked cannabis use to an array of negative outcomes, including psychiatric symptoms, cognitive impairment, and educational and occupational underachievement. These associations are particularly strong when cannabis use occurs in adolescence. Nevertheless, causality remains unclear. The purpose of the present study was thus to examine associations between prospectively assessed adolescent cannabis use and… Continue reading Associations between adolescent #cannabis use and young-adult functioning in three longitudinal twin studies
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