BackgroundWeight reduction has been shown to alleviate symptoms of osteoarthritis of the knee, including pain. The effect of glucagon-like peptide-1 receptor agonists on outcomes in knee osteoarthritis among persons with obesity has not been well studied.MethodsWe conducted a 68-week, double-blind, randomized, placebo-controlled trial at 61 sites in 11 countries. Participants with obesity (a body-mass index… Continue reading Once-Weekly #Semaglutide in Persons with #Obesity and #Knee Osteoarthritis
Category: Orthopedy
#Acupuncture vs Sham Acupuncture for Chronic #Sciatica From Herniated Disk
Importance Sciatica is commonly caused by herniated lumbar disc and contributes to severe pain and prolonged disability. Although acupuncture is widely used by patients with chronic sciatica, the evidence of its efficacy is scarce.Objective To investigate the efficacy and safety of acupuncture compared with sham acupuncture in patients with chronic sciatica from herniated disk.Design, Settings,… Continue reading #Acupuncture vs Sham Acupuncture for Chronic #Sciatica From Herniated Disk
#Running is acceptable and efficacious in adults with non-specific chronic low #back pain: the ASTEROID randomised controlled trial
AbstractObjectives Running is one of the most accessible forms of exercise, yet its suitability for adults with chronic low back pain (LBP) is unknown. This study assessed the efficacy and acceptability of running in adults with chronic LBP.Methods This two-arm parallel (1:1) individually randomised controlled trial allocated 40 participants (mean (SD) age: 33 (6) years,… Continue reading #Running is acceptable and efficacious in adults with non-specific chronic low #back pain: the ASTEROID randomised controlled trial
Precise Lubrication and Protection of #Cartilage Damage by Targeting #Hydrogel Microsphere
Osteoarthritis (OA) is a degenerative bone and joint disease characterized by decreased cartilage lubrication, leading to continuous wear and ultimately irreversible damage. This situation is particularly challenging for early-stage OA, as current bio-lubricants lack precise targeting for small inflammatory lesions. In this work, an antibody-mediated targeting hydrogel microspheres (HMS) is developed to precisely lubricate the… Continue reading Precise Lubrication and Protection of #Cartilage Damage by Targeting #Hydrogel Microsphere
Effectiveness and cost-effectiveness of an individualised, progressive #walking and education intervention for the prevention of low back #pain recurrence in Australia (WalkBack): a randomised controlled trial
BackgroundRecurrence of low back pain is common and a substantial contributor to the disease and economic burden of low back pain. Exercise is recommended to prevent recurrence, but the effectiveness and cost-effectiveness of an accessible and low-cost intervention, such as walking, is yet to be established. We aimed to investigate the clinical effectiveness and cost-effectiveness… Continue reading Effectiveness and cost-effectiveness of an individualised, progressive #walking and education intervention for the prevention of low back #pain recurrence in Australia (WalkBack): a randomised controlled trial
An #osteoarthritis pathophysiological continuum revealed by molecular #biomarkers
We aimed to identify serum biomarkers that predict knee osteoarthritis (OA) before the appearance of radiographic abnormalities in a cohort of 200 women. As few as six serum peptides, corresponding to six proteins, reached AUC 77% probability to distinguish those who developed OA from age-matched individuals who did not develop OA up to 8 years… Continue reading An #osteoarthritis pathophysiological continuum revealed by molecular #biomarkers
Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
Chronic musculoskeletal pain (CMP), a prevalent and heterogeneous condition characterized by persistent pain in various body parts, is a leading cause of disability worldwide and greatly affects a patient’s brain. Apart from experiencing pain, older adults with CMP also have accelerated cognitive decline and higher dementia risk with limited understanding of biological mechanism underlying the… Continue reading Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
Genetic investigation into the broad health implications of #caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
BackgroundCaffeine is one of the most utilized drugs in the world, yet its clinical effects are not fully understood. Circulating caffeine levels are influenced by the interplay between consumption behaviour and metabolism. This study aimed to investigate the effects of circulating caffeine levels by considering genetically predicted variation in caffeine metabolism.MethodsLeveraging genetic variants related to… Continue reading Genetic investigation into the broad health implications of #caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
#Dietary inflammatory index and MRI-detected #knee structural change and pain: a 10.7-year follow-up study
To determine whether the dietary inflammatory index (DII®) scores were associated with knee structural changes and pain over a 10.7-year follow-up.MethodsThis study utilised data from a prospective population-based cohort study (mean age 63 years, 51% female) in which 1,099, 875, 768 and 566 participants completed assessments at baseline, 2.6, 5.1 and 10.7 years, respectively. T1-weighted and T2-weighted… Continue reading #Dietary inflammatory index and MRI-detected #knee structural change and pain: a 10.7-year follow-up study
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