BackgroundAromatase inhibitor-induced arthralgia (AIA) is a frequent adverse effect of endocrine therapy in breast cancer survivors, often leading to treatment modification or discontinuation. Non-pharmacological interventions have been proposed to manage AIA, but evidence remains fragmented.ObjectiveTo synthesize recent randomized controlled trials (RCTs) evaluating the efficacy of non-pharmacological interventions for AIA.MethodsA systematic search of PubMed, Scopus, and… Continue reading Effectiveness of Non-Pharmacological Interventions for Hormone Therapy-Induced #Hand #Arthralgia in Breast Cancer Patients: A Systematic Review
Category: Orthopedy
Pain management in the perioperative orthogeriatric setting: Recommendations of the special interest group Orthogeriatrics of the German Geriatrics Society
Management of perioperative pain in older adults can be challenging. Multimorbidity, functional decline or diminished physiological reserves, the corresponding polypharmacy, age-related pharmacodynamic and pharmacokinetic changes need to be considered. #Pain assessment can be complicated by cognitive impairment and communication barriers. Older adults are at high risk of adverse consequences from surgery and undertreated pain as… Continue reading Pain management in the perioperative orthogeriatric setting: Recommendations of the special interest group Orthogeriatrics of the German Geriatrics Society
Cefazolin and the R1 Side Chain: Why Patients with a Cephalosporin Allergy Can Be Safely Given Cefazolin While Undergoing Joint Arthroplasty
Background: #Cefazolin , a first-generation #cephalosporin , is the standard antibiotic for perioperative prophylaxis in patients undergoing hip or knee arthroplasty. Research has demonstrated significantly higher periprosthetic joint infection ( #PJI ) rates when non-cefazolin antibiotics are used for prophylaxis. Notably, cefazolin contains an R1 side chain that has not shown cross-reactivity with other cephalosporins.… Continue reading Cefazolin and the R1 Side Chain: Why Patients with a Cephalosporin Allergy Can Be Safely Given Cefazolin While Undergoing Joint Arthroplasty
Synovial interleukin-6 point-of-care testing, alone and combined with D-dimer, supports rapid diagnosis of periprosthetic joint infection
Purpose: Data on the reliability of point-of-care (POC) tests for the rapid diagnosis of periprosthetic joint infections (PJI) using synovial fluid (SF) #D-dimer (DD), interleukin 6 (IL-6) and procalcitonin (PCT) are limited. This study aimed to address this issue by evaluating the diagnostic accuracy of POC tests for SF DD, IL-6 and PCT in comparison… Continue reading Synovial interleukin-6 point-of-care testing, alone and combined with D-dimer, supports rapid diagnosis of periprosthetic joint infection
Revisiting D-dimer in periprosthetic joint infection: a comprehensive systematic review and meta-analysis with subgroup and heterogeneity exploration
Background: #D-dimer has gained considerable attention since its inclusion as a minor criterion in the 2018 International Consensus Meeting. However, evidence regarding its diagnostic accuracy for periprosthetic joint infection ( #PJI ) remains inconclusive. This systematic review and meta-analysis aimed to evaluate the diagnostic performance of D-dimer in diagnosing PJI and comprehensively explore the sources… Continue reading Revisiting D-dimer in periprosthetic joint infection: a comprehensive systematic review and meta-analysis with subgroup and heterogeneity exploration
#Knee flexion during skin preparation improves anterior #antiseptic coverage: A controlled fluorescent dye study
AbstractBackground: Periprosthetic joint infection ( #PJI ) is a rare but devastating complication of total knee arthroplasty (TKA) and a leading cause of TKA failure. Thorough skin preparation is a key preventative measure; however, the influence of limb position on antiseptic coverage has not been evaluated. This study compared the effectiveness of anterior knee antiseptic… Continue reading #Knee flexion during skin preparation improves anterior #antiseptic coverage: A controlled fluorescent dye study
Cost-Effectiveness of #Acupuncture Needling for Older Adults With Chronic Low #Back Pain
Preplanned economic evaluation alongside a clinical trial.Objective. Determine the 1-year cost-effectiveness from health care sector and Medicare perspectives of adding either standard #acupuncture (SA; ≤15 treatment sessions over 12 wk) or enhanced acupuncture (EA; SA plus ≤ 6 additional sessions) to usual medical care (UMC) versus UMC alone.Summary of Background Data. Chronic low back #pain… Continue reading Cost-Effectiveness of #Acupuncture Needling for Older Adults With Chronic Low #Back Pain
The effect of post-operative continuous negative pressure therapy after debridement, antibiotics, and implant retention for acute #periprosthetic joint infection
Background: Acute periprosthetic joint infection (#PJI ) is a serious complication after total knee and hip replacement, with varying success rates in its management using debridement, antibiotics, and implant retention (DAIR). We hypothesize that the application of post-operative continuous negative pressure therapy (CNPT) can improve the success rate of DAIR in the treatment of acute… Continue reading The effect of post-operative continuous negative pressure therapy after debridement, antibiotics, and implant retention for acute #periprosthetic joint infection
Effect of core stabilization exercises on #lumbar multifidus morphology and functional outcomes in chronic non-specific low #back pain: a randomized controlled trial
Background: Chronic non-specific low back pain (CNSLBP) is often associated with morphological changes in the lumbar multifidus muscle (LMF), such as reduced cross-sectional area (CSA) and increased fat infiltration, compromising spinal stability and function. Core stabilization exercises aim to enhance neuromuscular control by targeting deep trunk muscles. However, few randomized trials have investigated their effects… Continue reading Effect of core stabilization exercises on #lumbar multifidus morphology and functional outcomes in chronic non-specific low #back pain: a randomized controlled trial
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