We report the kinetics of immune responses in relation to clinical and virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) that required hospitalization. Increased antibody-secreting cells (ASCs), follicular helper T cells (TFH cells), activated CD4+ T cells and CD8+ T cells and immunoglobulin M (IgM) and IgG antibodies that bound the COVID-19-causing… Continue reading Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe #COVID-19
Category: Infectivology
Characteristics and Outcomes of 21 Critically Ill Patients With #COVID-19 in Washington State
..A total of 21 cases were included (mean age, 70 years [range, 43-92 years]; 52% male). Comorbidities were identified in 18 cases (86%), with chronic kidney disease and congestive heart failure being the most common. Initial symptoms included shortness of breath (76%), fever (52%), and cough (48%) (Table 1). The mean onset of symptoms prior… Continue reading Characteristics and Outcomes of 21 Critically Ill Patients With #COVID-19 in Washington State
A Trial of #Lopinavir–#Ritonavir in Adults Hospitalized with Severe #Covid-19
..Treatment with lopinavir–ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical improvement, 1.24; 95% confidence interval [CI], 0.90 to 1.72). Mortality at 28 days was similar in the lopinavir–ritonavir group and the standard-care group (19.2% vs. 25.0%; difference, −5.8 percentage points; 95% CI, −17.3… Continue reading A Trial of #Lopinavir–#Ritonavir in Adults Hospitalized with Severe #Covid-19
Aerosol and Surface Stability of #SARS-CoV-2 as Compared with SARS-CoV-1
..SARS-CoV-2 remained viable in aerosols throughout the duration of our experiment (3 hours), with a reduction in infectious titer from 103.5 to 102.7 TCID50 per liter of air. This reduction was similar to that observed with SARS-CoV-1, from 104.3 to 103.5 TCID50 per milliliter (Figure 1A). SARS-CoV-2 was more stable on plastic and stainless steel… Continue reading Aerosol and Surface Stability of #SARS-CoV-2 as Compared with SARS-CoV-1
Antibiotic Use and Outcomes in Children in the Emergency Department With Suspected #Pneumonia
Antibiotic therapy is often prescribed for suspected community-acquired pneumonia (CAP) in children despite a lack of knowledge of causative pathogen. Our objective in this study was to investigate the association between antibiotic prescription and treatment failure in children with suspected CAP who are discharged from the hospital emergency department (ED).. ..Of 337 eligible children, 294… Continue reading Antibiotic Use and Outcomes in Children in the Emergency Department With Suspected #Pneumonia
Risk Factors Associated With Acute #Respiratory Distress Syndrome and Death in Patients With #Coronavirus Disease 2019 Pneumonia in Wuhan, China
Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been well delineated.. ..Of 201 patients, the median age was 51 years (interquartile range, 43-60 years), and 128 (63.7%) patients were men.… Continue reading Risk Factors Associated With Acute #Respiratory Distress Syndrome and Death in Patients With #Coronavirus Disease 2019 Pneumonia in Wuhan, China
Relationship between the ABO #Blood Group and the #COVID-19 Susceptibility
Detection of ABO blood groups, infection occurrence of SARS-CoV-2, and patient death RESULTS The ABO group in 3694 normal people in Wuhan showed a distribution of 32.16%, 24.90%, 9.10% and 33.84% for A, B, AB and O, respectively, versus the distribution of 37.75%, 26.42%, 10.03% and 25.80% for A, B, AB and O, respectively, in… Continue reading Relationship between the ABO #Blood Group and the #COVID-19 Susceptibility
Critical Care Utilization for the #COVID-19 Outbreak in Lombardy, Italy Early Experience and Forecast During an Emergency Response
On February 20, 2020, a patient in his 30s admitted to the intensive care unit (ICU) in Codogno Hospital (Lodi, Lombardy, Italy) tested positive for a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). He had a history of atypical pneumonia that was not responding to… Continue reading Critical Care Utilization for the #COVID-19 Outbreak in Lombardy, Italy Early Experience and Forecast During an Emergency Response
Clinical course and risk factors for mortality of adult inpatients with #COVID-19 in Wuhan, China: a retrospective cohort study
Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described..… Continue reading Clinical course and risk factors for mortality of adult inpatients with #COVID-19 in Wuhan, China: a retrospective cohort study
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