The action of mRNA-based vaccines requires the expression of the antigen in cells targeted by lipid nanoparticle–mRNA complexes. When the vaccine antigen is not fully retained by the producer cells, its local and systemic diffusion can have consequences depending on both the levels of antigen expression and its biological activity. A peculiarity of mRNA-based COVID-19… Continue reading The Immunologic Downsides Associated with the Powerful Translation of Current #COVID-19 Vaccine #mRNA Can Be Overcome by Mucosal Vaccines
Category: Infectivology
Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected #SepsisThe ADAPT-Sepsis Randomized Clinical Trial
Question Do critically ill adult patients hospitalized for suspected sepsis and treated with intravenous antibiotics based on procalcitonin (PCT) or C-reactive protein (CRP) protocols, have a safe reduction in treatment duration compared with standard care?Findings In this multicenter, randomized trial of 2760 patients, the daily PCT-guided protocol reduced total antibiotic duration and had noninferior all-cause… Continue reading Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected #SepsisThe ADAPT-Sepsis Randomized Clinical Trial
OpenSAFELY: Effectiveness of #COVID-19 #vaccination in #children and sadolescents
Background Children and adolescents in England were offered BNT162b2 as part of the national COVID-19 vaccine roll out from September 2021. We assessed the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination in children and adolescents in England.Methods With the approval of NHS England, we conducted an observational study in the OpenSAFELY-TPP… Continue reading OpenSAFELY: Effectiveness of #COVID-19 #vaccination in #children and sadolescents
Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
Background: The COVID-19 pandemic adversely affected the severity and prognosis of patients with acute myocardial infarction (MI) caused by atherothrombosis (type 1 MI). The effect, if any, of COVID-19 vaccination and natural SARS-CoV2 serologic immunity in these patients is unclear. Our aim was to analyze the association between the severity and outcome of patients with type… Continue reading Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
#Antibiotics damage the #colonic mucus barrier in a #microbiota-independent manner
Antibiotic use is a risk factor for development of inflammatory bowel diseases (IBDs). IBDs are characterized by a damaged mucus layer, which does not separate the intestinal epithelium from the microbiota. Here, we hypothesized that antibiotics affect the integrity of the mucus barrier, which allows bacterial penetrance and predisposes to intestinal inflammation. We found that… Continue reading #Antibiotics damage the #colonic mucus barrier in a #microbiota-independent manner
#Spike Protein Impairs #Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying #Cardiac Injury in COVID-19
Background: COVID-19 has a major impact on cardiovascular diseases and may lead to myocarditis or cardiac failure. The clove-like spike (S) protein of SARS-CoV-2 facilitates its transmission and pathogenesis. Cardiac mitochondria produce energy for key heart functions. We hypothesized that S1 would directly impair the functions of cardiomyocyte mitochondria, thus causing cardiac dysfunction.Methods: Through the Seahorse Mito… Continue reading #Spike Protein Impairs #Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying #Cardiac Injury in COVID-19
A case of biopsy-proven inflammatory dilated #cardiomyopathy following heterologous #mRNA -1273 third-dose immunization
Advances in mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have helped curb the coronavirus disease 2019 (COVID-19) pandemic and prevent disease onset and severity. Growing cases of vaccine-associated myocarditis (VAM) following SARS-CoV-2 immunization have been reported. Although COVID-19 VAM commonly occurs in young males after the second dose of vaccination, most cases are… Continue reading A case of biopsy-proven inflammatory dilated #cardiomyopathy following heterologous #mRNA -1273 third-dose immunization
#Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
•Early-life antibiotics increase the risk of allergy in adulthood•Antibiotics cause short-term disruption of the microbiome and systemic metabolome•Dysfunctional mitochondria in the airway epithelium lead to exaggerated inflammation•Indole-3-propionic acid counters the detrimental effects of early-life antibioticsSummaryAntibiotic use in early life disrupts microbial colonization and increases the risk of developing allergies and asthma. We report that mice… Continue reading #Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
A Systematic REVIEW of #Autopsy findings in deaths after #covid-19 vaccination
Highlights•We found that 73.9% of deaths were directly due to or significantly contributed to by COVID-19 vaccination.•Our data suggest a high likelihood of a causal link between COVID-19 vaccination and death.•These findings indicate the urgent need to elucidate the pathophysiologic mechanisms of death with the goal of risk stratification and avoidance of death for the… Continue reading A Systematic REVIEW of #Autopsy findings in deaths after #covid-19 vaccination
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