Importance Upper respiratory tract infections (URTIs) are prevalent in children, prompting frequent health care consultations, especially among those with fever. Probiotics show potential as an adjuvant treatment for URTIs, but evidence in children is limited.Objective To evaluate the efficacy of a probiotic mixture containing Bifidobacterium breve M-16V, Bifidobacterium lactis HN019, and Lactobacillus rhamnosus HN001 in… Continue reading #Probiotics and #Fever Duration in Children With Upper Respiratory Tract Infections
Category: Infectivology
The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Introduction: Vaccine-related myocarditis is recognized as a rare but important complication, especially after mass-scale mRNA COVID-19 vaccination. Knowledge regarding how to minimize the risk is limited. As NK cells can mediate acute myocarditis after mRNA COVID-19 vaccination and vitamin D may inhibit NK cells via cytokine modulation, we hypothesize that the myocarditis side effect is… Continue reading The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Development of a rapid antigen-based lateral flow assay for tick-borne spotted fever #rickettsioses
Tick-borne spotted fever rickettsioses (SFRs) continue to cause severe illness and death in otherwise-healthy individuals due to lack of a timely and reliable diagnostic laboratory test. We recently identified a diagnostic biomarker for SFRs, the putative N-acetylmuramoyl-l-alanine amidase RC0497. Here, we developed a prototype laboratory test that targets RC0497 for diagnosis of SFRs. The concentrations… Continue reading Development of a rapid antigen-based lateral flow assay for tick-borne spotted fever #rickettsioses
The influence of mechanical #ventilation and portable air cleaners upon aerosol spread in a hospital outpatients clinic
The SARS-CoV-2 global pandemic has highlighted the risk of nosocomial infections of airborne viruses to patient populations around the world. Increased use of mechanical ventilation and portable air cleaners (PACs) have been suggested as methods to mitigate this risk, but the introduction of new air flows to indoor areas can have complex and potentially unforeseen… Continue reading The influence of mechanical #ventilation and portable air cleaners upon aerosol spread in a hospital outpatients clinic
The physicochemical properties of #lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation
Lipopolysaccharide (LPS) is the primary pathogenic factor in Gram-negative sepsis. While the presence of LPS in the bloodstream during infection is associated with disseminated intravascular coagulation, the mechanistic link between LPS and blood coagulation activation remains ill-defined. The contact pathway of coagulation—a series of biochemical reactions that initiates blood clotting when plasma factors XII (FXII)… Continue reading The physicochemical properties of #lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation
The Immunologic Downsides Associated with the Powerful Translation of Current #COVID-19 Vaccine #mRNA Can Be Overcome by Mucosal Vaccines
The action of mRNA-based vaccines requires the expression of the antigen in cells targeted by lipid nanoparticle–mRNA complexes. When the vaccine antigen is not fully retained by the producer cells, its local and systemic diffusion can have consequences depending on both the levels of antigen expression and its biological activity. A peculiarity of mRNA-based COVID-19… Continue reading The Immunologic Downsides Associated with the Powerful Translation of Current #COVID-19 Vaccine #mRNA Can Be Overcome by Mucosal Vaccines
Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected #SepsisThe ADAPT-Sepsis Randomized Clinical Trial
Question Do critically ill adult patients hospitalized for suspected sepsis and treated with intravenous antibiotics based on procalcitonin (PCT) or C-reactive protein (CRP) protocols, have a safe reduction in treatment duration compared with standard care?Findings In this multicenter, randomized trial of 2760 patients, the daily PCT-guided protocol reduced total antibiotic duration and had noninferior all-cause… Continue reading Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected #SepsisThe ADAPT-Sepsis Randomized Clinical Trial
OpenSAFELY: Effectiveness of #COVID-19 #vaccination in #children and sadolescents
Background Children and adolescents in England were offered BNT162b2 as part of the national COVID-19 vaccine roll out from September 2021. We assessed the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination in children and adolescents in England.Methods With the approval of NHS England, we conducted an observational study in the OpenSAFELY-TPP… Continue reading OpenSAFELY: Effectiveness of #COVID-19 #vaccination in #children and sadolescents
Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
Background: The COVID-19 pandemic adversely affected the severity and prognosis of patients with acute myocardial infarction (MI) caused by atherothrombosis (type 1 MI). The effect, if any, of COVID-19 vaccination and natural SARS-CoV2 serologic immunity in these patients is unclear. Our aim was to analyze the association between the severity and outcome of patients with type… Continue reading Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
2 Medical News 