Evidence regarding the effect of dietary niacin intake on the risk of mortality among patients with nonalcoholic fatty liver disease (NAFLD) is scarce.Objective To examine the association of dietary niacin intake with all-cause mortality and cardiovascular disease (CVD) mortality among individuals with NAFLD.Design, Setting, and Participants This cohort study used data from the National Health and Nutrition… Continue reading Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
Category: Hepatology
Undiagnosed #Cirrhosis and Hepatic #Encephalopathy in a National Cohort of Veterans With #Dementia
Dementia and hepatic encephalopathy (HE) are challenging to distinguish clinically. Undiagnosed cirrhosis in a patient with dementia can lead to missed opportunities to treat HE.Objective To examine the prevalence and risk factors of undiagnosed cirrhosis and therefore possible HE in veterans with dementia.Design, Setting, and Participants A retrospective cohort study was conducted between 2009 and 2019 using… Continue reading Undiagnosed #Cirrhosis and Hepatic #Encephalopathy in a National Cohort of Veterans With #Dementia
ACG Clinical Guideline: #Alcohol-Associated #Liver Disease
Alcohol-associated liver disease (ALD) is the most common cause of advanced hepatic disease and frequent indication for liver transplantation worldwide. With harmful alcohol use as the primary risk factor, increasing alcohol use over the past decade has resulted in rapid growth of the ALD-related healthcare burden. The spectrum of ALD ranges from early asymptomatic liver… Continue reading ACG Clinical Guideline: #Alcohol-Associated #Liver Disease
Balancing Act – Navigating Acid-Base Disorders in Cirrhosis Patients – A Physician’s Perspective
Cirrhosis, a complex and progressive liver disease, poses myriad challenges for physicians. Among its many complications, acid-base disorders often emerge as a perplexing aspect of patient care. Understanding the intricate interplay between liver dysfunction, acid-base balance, and the clinical implications thereof is pivotal for physicians managing cirrhosis patients. In this post, I embark on a… Continue reading Balancing Act – Navigating Acid-Base Disorders in Cirrhosis Patients – A Physician’s Perspective
Development and Validation of the Nonalcoholic #Fatty Liver Disease Familial Risk Score to Detect Advanced #Fibrosis: A Prospective, Multicenter Study
Nonalcoholic fatty liver disease (NAFLD)-related fibrosis is heritable, but it is unclear how family history may be used to identify first-degree relatives with advanced fibrosis. We aimed to develop and validate a simple risk score to identify first-degree relatives of probands who have undergone assessment of liver fibrosis who are at higher risk of NAFLD… Continue reading Development and Validation of the Nonalcoholic #Fatty Liver Disease Familial Risk Score to Detect Advanced #Fibrosis: A Prospective, Multicenter Study
Association between diet soft #drink consumption and #metabolic dysfunction-associated #steatotic liver disease: findings from the NHANES
Lifestyle change plays a crucial role in the prevention and treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). In recent years, diet soft drinks that emphasize “zero sugar and zero calories” have become all the rage, but whether diet soft drink consumption is associated with MASLD is not clear.MethodsThis study included data from the National… Continue reading Association between diet soft #drink consumption and #metabolic dysfunction-associated #steatotic liver disease: findings from the NHANES
Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis
Clinical and preclinical studies established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic steatohepatitis (NASH) but molecular underpinnings of this action were elusive. Herein, we used multi-omic network analysis that unveiled critical molecular pathways involved in ω3 PUFA effects in a preclinical mouse model of western diet induced… Continue reading Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis
The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University Study
Non-Alcoholic Fatty Liver Disease (NAFLD) has emerged as a significant public health concern, affecting millions of individuals worldwide. Characterized by the accumulation of fat in the liver without excessive alcohol consumption, NAFLD can progress to more severe conditions, such as non-alcoholic steatohepatitis (NASH) and cirrhosis. While lifestyle modifications remain a cornerstone in managing NAFLD, recent… Continue reading The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University Study
Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
Hepatobiliary cancers share risk factors with colorectal cancer (CRC), but there are no combined screening programs for these conditions.AimsThe aim of this study was to assess whether patients with high-risk colonic polyps are more likely to die from liver related tumors than patients with a negative colonoscopy.MethodsIn this retrospective analysis of mortality data, Austrian screening… Continue reading Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
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